diff --git a/mlir/CMakeLists.txt b/mlir/CMakeLists.txt
--- a/mlir/CMakeLists.txt
+++ b/mlir/CMakeLists.txt
@@ -86,9 +86,16 @@
 add_dependencies(mlir-headers mlir-generic-headers)
 add_custom_target(mlir-doc)
 
+# Only enable execution engine if the native target is available.
+if(${LLVM_NATIVE_ARCH} IN_LIST LLVM_TARGETS_TO_BUILD)
+  set(MLIR_ENABLE_EXECUTION_ENGINE 1)
+else()
+  set(MLIR_ENABLE_EXECUTION_ENGINE 0)
+endif()
+
 # Build the CUDA conversions and run according tests if the NVPTX backend
 # is available
-if ("NVPTX" IN_LIST LLVM_TARGETS_TO_BUILD)
+if ("NVPTX" IN_LIST LLVM_TARGETS_TO_BUILD AND MLIR_ENABLE_EXECUTION_ENGINE)
   set(MLIR_ENABLE_CUDA_CONVERSIONS 1)
 else()
   set(MLIR_ENABLE_CUDA_CONVERSIONS 0)
@@ -97,8 +104,8 @@
 add_definitions(-DMLIR_CUDA_CONVERSIONS_ENABLED=${MLIR_ENABLE_CUDA_CONVERSIONS})
 
 # Build the ROCm conversions and run according tests if the AMDGPU backend
-# is available
-if ("AMDGPU" IN_LIST LLVM_TARGETS_TO_BUILD)
+# is available.
+if ("AMDGPU" IN_LIST LLVM_TARGETS_TO_BUILD AND MLIR_ENABLE_EXECUTION_ENGINE)
   set(MLIR_ENABLE_ROCM_CONVERSIONS 1)
 else()
   set(MLIR_ENABLE_ROCM_CONVERSIONS 0)
diff --git a/mlir/lib/CAPI/CMakeLists.txt b/mlir/lib/CAPI/CMakeLists.txt
--- a/mlir/lib/CAPI/CMakeLists.txt
+++ b/mlir/lib/CAPI/CMakeLists.txt
@@ -15,8 +15,7 @@
 add_subdirectory(RegisterEverything)
 add_subdirectory(Transforms)
 
-# Only enable the ExecutionEngine if the native target is configured in.
-if(TARGET ${LLVM_NATIVE_ARCH})
+if(MLIR_ENABLE_EXECUTION_ENGINE)
   add_subdirectory(ExecutionEngine)
 endif()
 
diff --git a/mlir/lib/ExecutionEngine/CMakeLists.txt b/mlir/lib/ExecutionEngine/CMakeLists.txt
--- a/mlir/lib/ExecutionEngine/CMakeLists.txt
+++ b/mlir/lib/ExecutionEngine/CMakeLists.txt
@@ -39,8 +39,7 @@
   Passes
   )
 
-# Only enable the ExecutionEngine if the native target is configured in.
-if(NOT TARGET ${LLVM_NATIVE_ARCH})
+if(NOT MLIR_ENABLE_EXECUTION_ENGINE)
   return()
 endif()
 
diff --git a/mlir/python/CMakeLists.txt b/mlir/python/CMakeLists.txt
--- a/mlir/python/CMakeLists.txt
+++ b/mlir/python/CMakeLists.txt
@@ -363,8 +363,7 @@
     MLIRCAPIAsync
 )
 
-# Only enable the ExecutionEngine if the native target is configured in.
-if(TARGET ${LLVM_NATIVE_ARCH})
+if(MLIR_ENABLE_EXECUTION_ENGINE)
   declare_mlir_python_extension(MLIRPythonExtension.ExecutionEngine
     MODULE_NAME _mlirExecutionEngine
     ADD_TO_PARENT MLIRPythonSources.ExecutionEngine
diff --git a/mlir/test/CAPI/CMakeLists.txt b/mlir/test/CAPI/CMakeLists.txt
--- a/mlir/test/CAPI/CMakeLists.txt
+++ b/mlir/test/CAPI/CMakeLists.txt
@@ -19,8 +19,7 @@
   endif()
 endfunction(_add_capi_test_executable)
 
-# Only enable the ExecutionEngine if the native target is configured in.
-if(TARGET ${LLVM_NATIVE_ARCH})
+if(MLIR_ENABLE_EXECUTION_ENGINE)
   _add_capi_test_executable(mlir-capi-execution-engine-test
     execution_engine.c
   LINK_LIBS PRIVATE
diff --git a/mlir/test/CMakeLists.txt b/mlir/test/CMakeLists.txt
--- a/mlir/test/CMakeLists.txt
+++ b/mlir/test/CMakeLists.txt
@@ -40,7 +40,7 @@
 
 
   # The native target may not be enabled when cross compiling, raise an error.
-  if(NOT TARGET ${LLVM_NATIVE_ARCH})
+  if(NOT MLIR_ENABLE_EXECUTION_ENGINE)
     message(FATAL_ERROR "MLIR_INCLUDE_INTEGRATION_TESTS requires a native target")
   endif()
 
diff --git a/mlir/tools/CMakeLists.txt b/mlir/tools/CMakeLists.txt
--- a/mlir/tools/CMakeLists.txt
+++ b/mlir/tools/CMakeLists.txt
@@ -9,8 +9,7 @@
 add_subdirectory(mlir-vulkan-runner)
 add_subdirectory(tblgen-lsp-server)
 
-# mlir-cpu-runner requires ExecutionEngine which is only built
-# when the native target is configured in.
-if(TARGET ${LLVM_NATIVE_ARCH})
+# mlir-cpu-runner requires ExecutionEngine.
+if(MLIR_ENABLE_EXECUTION_ENGINE)
   add_subdirectory(mlir-cpu-runner)
 endif()
diff --git a/mlir/unittests/CMakeLists.txt b/mlir/unittests/CMakeLists.txt
--- a/mlir/unittests/CMakeLists.txt
+++ b/mlir/unittests/CMakeLists.txt
@@ -16,7 +16,6 @@
 add_subdirectory(TableGen)
 add_subdirectory(Transforms)
 
-# The native target may not be enabled when cross compiling.
-if(TARGET ${LLVM_NATIVE_ARCH})
+if(MLIR_ENABLE_EXECUTION_ENGINE)
   add_subdirectory(ExecutionEngine)
 endif()