diff --git a/openmp/libomptarget/DeviceRTL/CMakeLists.txt b/openmp/libomptarget/DeviceRTL/CMakeLists.txt
--- a/openmp/libomptarget/DeviceRTL/CMakeLists.txt
+++ b/openmp/libomptarget/DeviceRTL/CMakeLists.txt
@@ -18,6 +18,12 @@
   return()
 endif()
 
+# Check to ensure the host system is a supported host architecture.
+if(NOT ${CMAKE_SIZEOF_VOID_P} EQUAL "8")
+  libomptarget_say("Not building DeviceRTL: Runtime does not support 32-bit hosts")
+  return()
+endif()
+
 if (LLVM_DIR)
   # Builds that use pre-installed LLVM have LLVM_DIR set.
   # A standalone or LLVM_ENABLE_RUNTIMES=openmp build takes this route