Index: llvm/include/llvm/Analysis/VectorUtils.h
===================================================================
--- llvm/include/llvm/Analysis/VectorUtils.h
+++ llvm/include/llvm/Analysis/VectorUtils.h
@@ -811,6 +811,9 @@
   /// cannot be filtered by masking the load/store.
   void invalidateGroupsRequiringScalarEpilogue();
 
+  /// Returns true if we have any interleave groups.
+  bool hasGroups() const { return !InterleaveGroups.empty(); }
+
 private:
   /// A wrapper around ScalarEvolution, used to add runtime SCEV checks.
   /// Simplifies SCEV expressions in the context of existing SCEV assumptions.
Index: llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
===================================================================
--- llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
+++ llvm/lib/Transforms/Vectorize/LoopVectorize.cpp
@@ -5051,7 +5051,7 @@
 
   // Invalidate interleave groups that require an epilogue if we can't mask
   // the interleave-group.
-  if (!useMaskedInterleavedAccesses(TTI)) {
+  if (InterleaveInfo.hasGroups() && !useMaskedInterleavedAccesses(TTI)) {
     assert(WideningDecisions.empty() && Uniforms.empty() && Scalars.empty() &&
            "No decisions should have been taken at this point");
     // Note: There is no need to invalidate any cost modeling decisions here, as
@@ -7448,7 +7448,8 @@
     return None;
 
   // Invalidate interleave groups if all blocks of loop will be predicated.
-  if (CM.blockNeedsPredicationForAnyReason(OrigLoop->getHeader()) &&
+  if (CM.InterleaveInfo.hasGroups() &&
+      CM.blockNeedsPredicationForAnyReason(OrigLoop->getHeader()) &&
       !useMaskedInterleavedAccesses(*TTI)) {
     LLVM_DEBUG(
         dbgs()