diff --git a/bolt/runtime/CMakeLists.txt b/bolt/runtime/CMakeLists.txt
--- a/bolt/runtime/CMakeLists.txt
+++ b/bolt/runtime/CMakeLists.txt
@@ -23,7 +23,8 @@
   -ffreestanding
   -fno-exceptions
   -fno-rtti
-  -fno-stack-protector)
+  -fno-stack-protector
+  -mno-sse)
 
 # Don't let the compiler think it can create calls to standard libs
 target_compile_options(bolt_rt_instr PRIVATE ${BOLT_RT_FLAGS} -fPIE)
diff --git a/bolt/test/runtime/X86/instrumentation-xmm.c b/bolt/test/runtime/X86/instrumentation-xmm.c
new file mode 100644
--- /dev/null
+++ b/bolt/test/runtime/X86/instrumentation-xmm.c
@@ -0,0 +1,25 @@
+#include <stdio.h>
+
+void foo(float a) {
+  printf("a = %f\n", a);
+}
+
+typedef void (*fptr_t)(float);
+fptr_t func = foo;
+
+int main() {
+  func(42);
+  return 0;
+}
+
+/*
+## Check that BOLT instrumentation runtime preserves xmm registers.
+
+REQUIRES: system-linux,bolt-runtime
+
+RUN: %clang %cflags %s -o %t.exe -fno-inline -Wl,-q
+RUN: llvm-bolt %t.exe --instrument -o %t.instrumented
+RUN: %t.instrumented | FileCheck %s
+
+CHECK: a = 42.000000
+*/