diff --git a/llvm/lib/Analysis/ValueTracking.cpp b/llvm/lib/Analysis/ValueTracking.cpp
--- a/llvm/lib/Analysis/ValueTracking.cpp
+++ b/llvm/lib/Analysis/ValueTracking.cpp
@@ -2698,6 +2698,9 @@
     if (isKnownNonZero(Op, Depth, Q) &&
         isGuaranteedNotToBePoison(Op, Q.AC, Q.CxtI, Q.DT, Depth))
       return true;
+  } else if (const auto *II = dyn_cast<IntrinsicInst>(V)) {
+    if (II->getIntrinsicID() == Intrinsic::vscale)
+      return true;
   }
 
   KnownBits Known(BitWidth);
diff --git a/llvm/test/Transforms/InstCombine/vscale_zero.ll b/llvm/test/Transforms/InstCombine/vscale_zero.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/InstCombine/vscale_zero.ll
@@ -0,0 +1,26 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s -passes=instcombine -S | FileCheck %s
+
+define i1 @iszero() {
+; CHECK-LABEL: @iszero(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    ret i1 false
+;
+  entry:
+  %0 = call i32 @llvm.vscale.i32()
+  %1 = icmp eq i32 %0, 0
+  ret i1 %1
+}
+
+define i1 @iszero_range() vscale_range(1,16) {
+; CHECK-LABEL: @iszero_range(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    ret i1 false
+;
+  entry:
+  %0 = call i32 @llvm.vscale.i32()
+  %1 = icmp eq i32 %0, 0
+  ret i1 %1
+}
+
+declare i32 @llvm.vscale.i32()