diff --git a/openmp/libomptarget/CMakeLists.txt b/openmp/libomptarget/CMakeLists.txt
--- a/openmp/libomptarget/CMakeLists.txt
+++ b/openmp/libomptarget/CMakeLists.txt
@@ -40,16 +40,22 @@
 # This is a list of all the targets that are supported/tested right now.
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} aarch64-unknown-linux-gnu")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} aarch64-unknown-linux-gnu-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} aarch64-unknown-linux-gnu-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} amdgcn-amd-amdhsa")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} amdgcn-amd-amdhsa-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} amdgcn-amd-amdhsa-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64le-ibm-linux-gnu")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64le-ibm-linux-gnu-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64le-ibm-linux-gnu-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64-ibm-linux-gnu")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64-ibm-linux-gnu-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} powerpc64-ibm-linux-gnu-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} x86_64-pc-linux-gnu")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} x86_64-pc-linux-gnu-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} x86_64-pc-linux-gnu-LTO")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda")
 set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda-oldDriver")
+set (LIBOMPTARGET_ALL_TARGETS "${LIBOMPTARGET_ALL_TARGETS} nvptx64-nvidia-cuda-LTO")
 
 # Once the plugins for the different targets are validated, they will be added to
 # the list of supported targets in the current system.
diff --git a/openmp/libomptarget/plugins/CMakeLists.txt b/openmp/libomptarget/plugins/CMakeLists.txt
--- a/openmp/libomptarget/plugins/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/CMakeLists.txt
@@ -57,6 +57,8 @@
       # Report to the parent scope that we are building a plugin.
       set(LIBOMPTARGET_SYSTEM_TARGETS
         "${LIBOMPTARGET_SYSTEM_TARGETS} ${tmachine_triple} ${tmachine_triple}-oldDriver" PARENT_SCOPE)
+      set(LIBOMPTARGET_SYSTEM_TARGETS
+        "${LIBOMPTARGET_SYSTEM_TARGETS} ${tmachine_triple} ${tmachine_triple}-LTO" PARENT_SCOPE)
       set(LIBOMPTARGET_TESTED_PLUGINS
         "${LIBOMPTARGET_TESTED_PLUGINS}" PARENT_SCOPE)
 
diff --git a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
--- a/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/amdgpu/CMakeLists.txt
@@ -117,6 +117,7 @@
 else()
   # Report to the parent scope that we are building a plugin for amdgpu
   set(LIBOMPTARGET_SYSTEM_TARGETS "${LIBOMPTARGET_SYSTEM_TARGETS} amdgcn-amd-amdhsa amdgcn-amd-amdhsa-oldDriver" PARENT_SCOPE)
+  set(LIBOMPTARGET_SYSTEM_TARGETS "${LIBOMPTARGET_SYSTEM_TARGETS} amdgcn-amd-amdhsa amdgcn-amd-amdhsa-LTO" PARENT_SCOPE)
   list(APPEND LIBOMPTARGET_TESTED_PLUGINS "omptarget.rtl.amdgpu")
   set(LIBOMPTARGET_TESTED_PLUGINS "${LIBOMPTARGET_TESTED_PLUGINS}" PARENT_SCOPE)
 endif()
diff --git a/openmp/libomptarget/plugins/cuda/CMakeLists.txt b/openmp/libomptarget/plugins/cuda/CMakeLists.txt
--- a/openmp/libomptarget/plugins/cuda/CMakeLists.txt
+++ b/openmp/libomptarget/plugins/cuda/CMakeLists.txt
@@ -74,6 +74,7 @@
 if (LIBOMPTARGET_CAN_LINK_LIBCUDA OR LIBOMPTARGET_FORCE_DLOPEN_LIBCUDA)
   libomptarget_say("Enable tests using CUDA plugin")
   set(LIBOMPTARGET_SYSTEM_TARGETS "${LIBOMPTARGET_SYSTEM_TARGETS} nvptx64-nvidia-cuda nvptx64-nvidia-cuda-oldDriver" PARENT_SCOPE)
+  set(LIBOMPTARGET_SYSTEM_TARGETS "${LIBOMPTARGET_SYSTEM_TARGETS} nvptx64-nvidia-cuda nvptx64-nvidia-cuda-LTO" PARENT_SCOPE)
   list(APPEND LIBOMPTARGET_TESTED_PLUGINS "omptarget.rtl.cuda")
   set(LIBOMPTARGET_TESTED_PLUGINS "${LIBOMPTARGET_TESTED_PLUGINS}" PARENT_SCOPE)
 else()
diff --git a/openmp/libomptarget/test/lit.cfg b/openmp/libomptarget/test/lit.cfg
--- a/openmp/libomptarget/test/lit.cfg
+++ b/openmp/libomptarget/test/lit.cfg
@@ -106,10 +106,14 @@
         config.test_flags += " --libomptarget-nvptx-bc-path=" + config.library_dir
     if config.libomptarget_current_target.endswith('-oldDriver'):
         config.test_flags += " -fno-openmp-new-driver"
+    if config.libomptarget_current_target.endswith('-LTO'):
+        config.test_flags += " -offload-lto"
 
 def remove_suffix_if_present(name):
     if name.endswith('-oldDriver'):
         return name[:-10]
+    if name.endswith('-LTO'):
+        return name[:-4]
     else:
         return name
 
diff --git a/openmp/libomptarget/test/mapping/data_member_ref.cpp b/openmp/libomptarget/test/mapping/data_member_ref.cpp
--- a/openmp/libomptarget/test/mapping/data_member_ref.cpp
+++ b/openmp/libomptarget/test/mapping/data_member_ref.cpp
@@ -3,6 +3,7 @@
 // Wrong results on amdgpu
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <stdio.h>
 
diff --git a/openmp/libomptarget/test/mapping/declare_mapper_nested_default_mappers.cpp b/openmp/libomptarget/test/mapping/declare_mapper_nested_default_mappers.cpp
--- a/openmp/libomptarget/test/mapping/declare_mapper_nested_default_mappers.cpp
+++ b/openmp/libomptarget/test/mapping/declare_mapper_nested_default_mappers.cpp
@@ -3,6 +3,7 @@
 // Wrong results on amdgpu
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <cstdio>
 #include <cstdlib>
diff --git a/openmp/libomptarget/test/mapping/declare_mapper_nested_mappers.cpp b/openmp/libomptarget/test/mapping/declare_mapper_nested_mappers.cpp
--- a/openmp/libomptarget/test/mapping/declare_mapper_nested_mappers.cpp
+++ b/openmp/libomptarget/test/mapping/declare_mapper_nested_mappers.cpp
@@ -3,6 +3,7 @@
 // Wrong results on amdgpu
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <cstdio>
 #include <cstdlib>
diff --git a/openmp/libomptarget/test/mapping/lambda_by_value.cpp b/openmp/libomptarget/test/mapping/lambda_by_value.cpp
--- a/openmp/libomptarget/test/mapping/lambda_by_value.cpp
+++ b/openmp/libomptarget/test/mapping/lambda_by_value.cpp
@@ -3,6 +3,7 @@
 // Wrong results on amdgpu
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <stdio.h>
 #include <stdint.h>
diff --git a/openmp/libomptarget/test/mapping/lambda_mapping.cpp b/openmp/libomptarget/test/mapping/lambda_mapping.cpp
--- a/openmp/libomptarget/test/mapping/lambda_mapping.cpp
+++ b/openmp/libomptarget/test/mapping/lambda_mapping.cpp
@@ -3,6 +3,7 @@
 // Error on the gpu that crashes the host
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-LTO
 
 #include <iostream>
 
diff --git a/openmp/libomptarget/test/mapping/map_back_race.cpp b/openmp/libomptarget/test/mapping/map_back_race.cpp
--- a/openmp/libomptarget/test/mapping/map_back_race.cpp
+++ b/openmp/libomptarget/test/mapping/map_back_race.cpp
@@ -2,9 +2,9 @@
 
 // Taken from https://github.com/llvm/llvm-project/issues/54216
 
-
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-oldDriver
+// UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 
 #include <algorithm>
 #include <cstdlib>
diff --git a/openmp/libomptarget/test/mapping/ompx_hold/struct.c b/openmp/libomptarget/test/mapping/ompx_hold/struct.c
--- a/openmp/libomptarget/test/mapping/ompx_hold/struct.c
+++ b/openmp/libomptarget/test/mapping/ompx_hold/struct.c
@@ -4,6 +4,7 @@
 // Wrong results on amdgpu
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <omp.h>
 #include <stdio.h>
diff --git a/openmp/libomptarget/test/offloading/bug49021.cpp b/openmp/libomptarget/test/offloading/bug49021.cpp
--- a/openmp/libomptarget/test/offloading/bug49021.cpp
+++ b/openmp/libomptarget/test/offloading/bug49021.cpp
@@ -3,6 +3,7 @@
 // Hangs
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-LTO
 
 #include <iostream>
 
diff --git a/openmp/libomptarget/test/offloading/bug49334.cpp b/openmp/libomptarget/test/offloading/bug49334.cpp
--- a/openmp/libomptarget/test/offloading/bug49334.cpp
+++ b/openmp/libomptarget/test/offloading/bug49334.cpp
@@ -3,8 +3,10 @@
 // Currently hangs on amdgpu
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-LTO
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-oldDriver
+// UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 
 #include <cassert>
 #include <cmath>
diff --git a/openmp/libomptarget/test/offloading/bug49779.cpp b/openmp/libomptarget/test/offloading/bug49779.cpp
--- a/openmp/libomptarget/test/offloading/bug49779.cpp
+++ b/openmp/libomptarget/test/offloading/bug49779.cpp
@@ -3,6 +3,7 @@
 
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-LTO
 
 #include <cassert>
 #include <iostream>
diff --git a/openmp/libomptarget/test/offloading/bug51781.c b/openmp/libomptarget/test/offloading/bug51781.c
--- a/openmp/libomptarget/test/offloading/bug51781.c
+++ b/openmp/libomptarget/test/offloading/bug51781.c
@@ -35,6 +35,7 @@
 // Hangs
 // UNSUPPORTED: amdgcn-amd-amdhsa
 // UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-LTO
 
 #if ADD_REDUCTION
 # define REDUCTION(...) reduction(__VA_ARGS__)
diff --git a/openmp/libomptarget/test/offloading/host_as_target.c b/openmp/libomptarget/test/offloading/host_as_target.c
--- a/openmp/libomptarget/test/offloading/host_as_target.c
+++ b/openmp/libomptarget/test/offloading/host_as_target.c
@@ -10,6 +10,7 @@
 // amdgpu does not have a working printf definition
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <stdio.h>
 #include <omp.h>
diff --git a/openmp/libomptarget/test/offloading/memory_manager.cpp b/openmp/libomptarget/test/offloading/memory_manager.cpp
--- a/openmp/libomptarget/test/offloading/memory_manager.cpp
+++ b/openmp/libomptarget/test/offloading/memory_manager.cpp
@@ -2,6 +2,7 @@
 
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-oldDriver
+// UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 
 #include <omp.h>
 
diff --git a/openmp/libomptarget/test/offloading/parallel_offloading_map.cpp b/openmp/libomptarget/test/offloading/parallel_offloading_map.cpp
--- a/openmp/libomptarget/test/offloading/parallel_offloading_map.cpp
+++ b/openmp/libomptarget/test/offloading/parallel_offloading_map.cpp
@@ -2,6 +2,7 @@
 
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-oldDriver
+// UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 
 #include <cassert>
 #include <iostream>
diff --git a/openmp/libomptarget/test/offloading/static_linking.c b/openmp/libomptarget/test/offloading/static_linking.c
--- a/openmp/libomptarget/test/offloading/static_linking.c
+++ b/openmp/libomptarget/test/offloading/static_linking.c
@@ -2,8 +2,8 @@
 // RUN: llvm-ar rcs %t.a %t.o
 // RUN: %libomptarget-compile-generic %t.a && %libomptarget-run-generic 2>&1 | %fcheck-generic
 
-// REQUIRES: nvptx64-nvidia-cuda-oldDriver
-// REQUIRES: amdgcn-amd-amdhsa-oldDriver
+// UNSUPPORTED: nvptx64-nvidia-cuda-oldDriver
+// UNSUPPORTED: amdgcn-amd-amdhsa-oldDriver
 
 #ifdef LIBRARY
 int x = 42;
diff --git a/openmp/libomptarget/test/offloading/taskloop_offload_nowait.cpp b/openmp/libomptarget/test/offloading/taskloop_offload_nowait.cpp
--- a/openmp/libomptarget/test/offloading/taskloop_offload_nowait.cpp
+++ b/openmp/libomptarget/test/offloading/taskloop_offload_nowait.cpp
@@ -2,6 +2,7 @@
 
 // UNSUPPORTED: x86_64-pc-linux-gnu
 // UNSUPPORTED: x86_64-pc-linux-gnu-oldDriver
+// UNSUPPORTED: x86_64-pc-linux-gnu-LTO
 
 #include <cmath>
 #include <cstdlib>
diff --git a/openmp/libomptarget/test/unified_shared_memory/api.c b/openmp/libomptarget/test/unified_shared_memory/api.c
--- a/openmp/libomptarget/test/unified_shared_memory/api.c
+++ b/openmp/libomptarget/test/unified_shared_memory/api.c
@@ -1,11 +1,12 @@
 // RUN: %libomptarget-compile-run-and-check-generic
 // XFAIL: nvptx64-nvidia-cuda
-// XFAIL: nvptx64-nvidia-cuda
 // XFAIL: nvptx64-nvidia-cuda-oldDriver
+// XFAIL: nvptx64-nvidia-cuda-LTO
 
 // Fails on amdgpu with error: GPU Memory Error
 // XFAIL: amdgcn-amd-amdhsa
 // XFAIL: amdgcn-amd-amdhsa-oldDriver
+// XFAIL: amdgcn-amd-amdhsa-LTO
 
 #include <stdio.h>
 #include <omp.h>