diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h b/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_interceptors.h
@@ -330,8 +330,7 @@
 #define SANITIZER_INTERCEPT_GETMNTENT_R SI_LINUX_NOT_ANDROID
 #define SANITIZER_INTERCEPT_STATFS \
   (SI_FREEBSD || SI_MAC || SI_LINUX_NOT_ANDROID || SI_SOLARIS)
-#define SANITIZER_INTERCEPT_STATFS64 \
-  (((SI_MAC && !TARGET_CPU_ARM64) && !SI_IOS) || SI_LINUX_NOT_ANDROID)
+#define SANITIZER_INTERCEPT_STATFS64 SANITIZER_HAS_STATFS64
 #define SANITIZER_INTERCEPT_STATVFS \
   (SI_FREEBSD || SI_NETBSD || SI_LINUX_NOT_ANDROID)
 #define SANITIZER_INTERCEPT_STATVFS64 SI_LINUX_NOT_ANDROID
@@ -468,7 +467,7 @@
 #define SANITIZER_INTERCEPT_STAT                                        \
   (SI_FREEBSD || SI_MAC || SI_ANDROID || SI_NETBSD || SI_SOLARIS ||     \
    SI_STAT_LINUX)
-#define SANITIZER_INTERCEPT_STAT64 SI_STAT_LINUX
+#define SANITIZER_INTERCEPT_STAT64 SI_STAT_LINUX || SANITIZER_HAS_STAT64
 #define SANITIZER_INTERCEPT_LSTAT (SI_NETBSD || SI_FREEBSD || SI_STAT_LINUX)
 #define SANITIZER_INTERCEPT___XSTAT \
   ((!SANITIZER_INTERCEPT_STAT && SI_POSIX) || SI_STAT_LINUX)
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_linux.cpp b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_linux.cpp
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_linux.cpp
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_linux.cpp
@@ -57,12 +57,6 @@
 
 using namespace __sanitizer;
 
-namespace __sanitizer {
-#if !SANITIZER_ANDROID
-  unsigned struct_statfs64_sz = sizeof(struct statfs64);
-#endif
-}  // namespace __sanitizer
-
 #  if !defined(__powerpc64__) && !defined(__x86_64__) &&                   \
       !defined(__aarch64__) && !defined(__mips__) && !defined(__s390__) && \
       !defined(__sparc__) && !defined(__riscv) && !defined(__hexagon__)
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.h b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.h
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.h
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.h
@@ -19,6 +19,25 @@
 #include "sanitizer_internal_defs.h"
 #include "sanitizer_platform.h"
 
+#if SANITIZER_APPLE
+#include <sys/cdefs.h>
+#if !__DARWIN_ONLY_64_BIT_INO_T
+#define SANITIZER_HAS_STAT64 1
+#define SANITIZER_HAS_STATFS64 1
+#else
+#define SANITIZER_HAS_STAT64 0
+#define SANITIZER_HAS_STATFS64 0
+#endif
+#else
+// Must be SANITIZER_LINUX then
+#define SANITIZER_HAS_STAT64 1
+#if SANITIZER_ANDROID
+#define SANITIZER_HAS_STATFS64 0 // Intercepting statfs64 seems to be broken on Android
+#else
+#define SANITIZER_HAS_STATFS64 1
+#endif
+#endif
+
 #if defined(__sparc__)
 // FIXME: This can't be included from tsan which does not support sparc yet.
 #include "sanitizer_glibc_version.h"
@@ -29,7 +48,7 @@
 namespace __sanitizer {
 extern unsigned struct_utsname_sz;
 extern unsigned struct_stat_sz;
-#if !SANITIZER_IOS
+#if SANITIZER_HAS_STAT64
 extern unsigned struct_stat64_sz;
 #endif
 extern unsigned struct_rusage_sz;
@@ -49,7 +68,9 @@
 extern unsigned struct_sigevent_sz;
 extern unsigned struct_stack_t_sz;
 extern unsigned struct_sched_param_sz;
+#if SANITIZER_HAS_STATFS64
 extern unsigned struct_statfs64_sz;
+#endif
 extern unsigned struct_regex_sz;
 extern unsigned struct_regmatch_sz;
 
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform_limits_posix.cpp
@@ -181,9 +181,9 @@
 namespace __sanitizer {
   unsigned struct_utsname_sz = sizeof(struct utsname);
   unsigned struct_stat_sz = sizeof(struct stat);
-#if !SANITIZER_IOS && !(SANITIZER_APPLE && TARGET_CPU_ARM64)
+#if SANITIZER_HAS_STAT64
   unsigned struct_stat64_sz = sizeof(struct stat64);
-#endif // !SANITIZER_IOS && !(SANITIZER_APPLE && TARGET_CPU_ARM64)
+#endif // SANITIZER_HAS_STAT64
   unsigned struct_rusage_sz = sizeof(struct rusage);
   unsigned struct_tm_sz = sizeof(struct tm);
   unsigned struct_passwd_sz = sizeof(struct passwd);
@@ -208,9 +208,9 @@
   unsigned struct_regex_sz = sizeof(regex_t);
   unsigned struct_regmatch_sz = sizeof(regmatch_t);
 
-#if (SANITIZER_APPLE && !TARGET_CPU_ARM64) && !SANITIZER_IOS
+#if SANITIZER_HAS_STATFS64
   unsigned struct_statfs64_sz = sizeof(struct statfs64);
-#endif // (SANITIZER_APPLE && !TARGET_CPU_ARM64) && !SANITIZER_IOS
+#endif // SANITIZER_HAS_STATFS64
 
 #if SANITIZER_GLIBC || SANITIZER_FREEBSD || SANITIZER_NETBSD || SANITIZER_APPLE
   unsigned struct_fstab_sz = sizeof(struct fstab);