diff --git a/clang/include/clang/StaticAnalyzer/Core/PathSensitive/ProgramState.h b/clang/include/clang/StaticAnalyzer/Core/PathSensitive/ProgramState.h
--- a/clang/include/clang/StaticAnalyzer/Core/PathSensitive/ProgramState.h
+++ b/clang/include/clang/StaticAnalyzer/Core/PathSensitive/ProgramState.h
@@ -123,11 +123,12 @@
   void setStore(const StoreRef &storeRef);
 
   ProgramStateRef cloneAsPosteriorlyOverconstrained() const;
+
+public:
   bool isPosteriorlyOverconstrained() const {
     return PosteriorlyOverconstrained;
   }
 
-public:
   /// This ctor is used when creating the first ProgramState object.
   ProgramState(ProgramStateManager *mgr, const Environment& env,
           StoreRef st, GenericDataMap gdm);
diff --git a/clang/lib/StaticAnalyzer/Core/RangeConstraintManager.cpp b/clang/lib/StaticAnalyzer/Core/RangeConstraintManager.cpp
--- a/clang/lib/StaticAnalyzer/Core/RangeConstraintManager.cpp
+++ b/clang/lib/StaticAnalyzer/Core/RangeConstraintManager.cpp
@@ -2534,6 +2534,9 @@
 LLVM_NODISCARD ProgramStateRef reAssume(ProgramStateRef State,
                                         const RangeSet *Constraint,
                                         SVal TheValue) {
+  assert(State);
+  if (State->isPosteriorlyOverconstrained())
+    return nullptr;
   if (!Constraint)
     return State;
 
diff --git a/clang/test/Analysis/runtime-regression.c b/clang/test/Analysis/runtime-regression.c
new file mode 100644
--- /dev/null
+++ b/clang/test/Analysis/runtime-regression.c
@@ -0,0 +1,54 @@
+// RUN: %clang_analyze_cc1 %s \
+// RUN:   -analyzer-checker=core,alpha.security.ArrayBoundV2 \
+// RUN:   -analyzer-checker=debug.ExprInspection \
+// RUN:   -verify
+
+// This test is here to check if there is no significant run-time regression
+// related to the assume machinery. This is an automatically reduced code. The
+// analysis should finish in less than 10 seconds.
+
+// expected-no-diagnostics
+
+typedef unsigned char uint8_t;
+typedef unsigned short uint16_t;
+typedef unsigned long uint64_t;
+
+int filter_slice_word(int sat_linesize, int sigma, int radius, uint64_t *sat,
+                      uint64_t *square_sat, int width, int height,
+                      int src_linesize, int dst_linesize, const uint16_t *src,
+                      uint16_t *dst, int jobnr, int nb_jobs) {
+  const int starty = height * jobnr / nb_jobs;
+  const int endy = height * (jobnr + 1) / nb_jobs;
+
+  for (int y = starty; y < endy; y++) {
+
+    int lower_y = y - radius < 0 ? 0 : y - radius;
+    int higher_y = y + radius + 1 > height ? height : y + radius + 1;
+    int dist_y = higher_y - lower_y;
+
+    for (int x = 0; x < width; x++) {
+
+      int lower_x = x - radius < 0 ? 0 : x - radius;
+      int higher_x = x + radius + 1 > width ? width : x + radius + 1;
+      int count = dist_y * (higher_x - lower_x);
+
+      // The below hunk caused significant regression in run-time.
+#if 1
+      uint64_t sum = sat[higher_y * sat_linesize + higher_x] -
+                     sat[higher_y * sat_linesize + lower_x] -
+                     sat[lower_y * sat_linesize + higher_x] +
+                     sat[lower_y * sat_linesize + lower_x];
+      uint64_t square_sum = square_sat[higher_y * sat_linesize + higher_x] -
+                            square_sat[higher_y * sat_linesize + lower_x] -
+                            square_sat[lower_y * sat_linesize + higher_x] +
+                            square_sat[lower_y * sat_linesize + lower_x];
+      uint64_t mean = sum / count;
+      uint64_t var = (square_sum - sum * sum / count) / count;
+      dst[y * dst_linesize + x] =
+          (sigma * mean + var * src[y * src_linesize + x]) / (sigma + var);
+#endif
+
+    }
+  }
+  return 0;
+}