diff --git a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
--- a/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstructionCombining.cpp
@@ -4191,8 +4191,9 @@
 
     // Now that we have an instruction, try combining it to simplify it.
     Builder.SetInsertPoint(I);
-    Builder.CollectMetadataToCopy(
-        I, {LLVMContext::MD_dbg, LLVMContext::MD_annotation});
+    Builder.CollectMetadataToCopy(I, {LLVMContext::MD_dbg,
+                                      LLVMContext::MD_annotation,
+                                      LLVMContext::MD_nosanitize});
 
 #ifndef NDEBUG
     std::string OrigI;
@@ -4208,7 +4209,8 @@
                           << "    New = " << *Result << '\n');
 
         Result->copyMetadata(*I,
-                             {LLVMContext::MD_dbg, LLVMContext::MD_annotation});
+                             {LLVMContext::MD_dbg, LLVMContext::MD_annotation,
+                              LLVMContext::MD_nosanitize});
         // Everything uses the new instruction now.
         I->replaceAllUsesWith(Result);