diff --git a/clang/docs/ReleaseNotes.rst b/clang/docs/ReleaseNotes.rst
--- a/clang/docs/ReleaseNotes.rst
+++ b/clang/docs/ReleaseNotes.rst
@@ -506,6 +506,9 @@
   `strcmp``, ``strncmp``, ``strcpy``, ``strlen``, ``strsep`` and many more. Although 
   this checker currently is in list of alpha checkers due to a false positive.
 
+- Deprecate ``-analyzer-store region`` analyzer flag. This flag is still
+  accepted, but ``clang-17`` will reject this flag.
+
 .. _release-notes-ubsan:
 
 Undefined Behavior Sanitizer (UBSan)
diff --git a/clang/include/clang/Driver/Options.td b/clang/include/clang/Driver/Options.td
--- a/clang/include/clang/Driver/Options.td
+++ b/clang/include/clang/Driver/Options.td
@@ -4966,8 +4966,9 @@
 def analysis_CFGAddImplicitDtors : Flag<["-"], "cfg-add-implicit-dtors">,
   HelpText<"Add C++ implicit destructors to CFGs for all analyses">;
 
+// We should remove this option in clang-17 release.
 def analyzer_store : Separate<["-"], "analyzer-store">,
-  HelpText<"Source Code Analysis - Abstract Memory Store Models">;
+  HelpText<"Source Code Analysis - Abstract Memory Store Models [DEPRECATED]">;
 def analyzer_store_EQ : Joined<["-"], "analyzer-store=">, Alias<analyzer_store>;
 
 def analyzer_constraints : Separate<["-"], "analyzer-constraints">,
diff --git a/clang/include/clang/StaticAnalyzer/Core/Analyses.def b/clang/include/clang/StaticAnalyzer/Core/Analyses.def
--- a/clang/include/clang/StaticAnalyzer/Core/Analyses.def
+++ b/clang/include/clang/StaticAnalyzer/Core/Analyses.def
@@ -10,13 +10,6 @@
 //
 //===----------------------------------------------------------------------===//
 
-#ifndef ANALYSIS_STORE
-#define ANALYSIS_STORE(NAME, CMDFLAG, DESC, CREATFN)
-#endif
-
-ANALYSIS_STORE(RegionStore, "region", "Use region-based analyzer store",
-               CreateRegionStoreManager)
-
 #ifndef ANALYSIS_CONSTRAINTS
 #define ANALYSIS_CONSTRAINTS(NAME, CMDFLAG, DESC, CREATFN)
 #endif
@@ -94,7 +87,6 @@
     NoRedundancy, "noredundancy",
     "Do not analyze a function which has been previously inlined")
 
-#undef ANALYSIS_STORE
 #undef ANALYSIS_CONSTRAINTS
 #undef ANALYSIS_DIAGNOSTICS
 #undef ANALYSIS_PURGE
diff --git a/clang/include/clang/StaticAnalyzer/Core/AnalyzerOptions.h b/clang/include/clang/StaticAnalyzer/Core/AnalyzerOptions.h
--- a/clang/include/clang/StaticAnalyzer/Core/AnalyzerOptions.h
+++ b/clang/include/clang/StaticAnalyzer/Core/AnalyzerOptions.h
@@ -40,13 +40,6 @@
 NumAnalyses
 };
 
-/// AnalysisStores - Set of available analysis store models.
-enum AnalysisStores {
-#define ANALYSIS_STORE(NAME, CMDFLAG, DESC, CREATFN) NAME##Model,
-#include "clang/StaticAnalyzer/Core/Analyses.def"
-NumStores
-};
-
 /// AnalysisConstraints - Set of available constraint models.
 enum AnalysisConstraints {
 #define ANALYSIS_CONSTRAINTS(NAME, CMDFLAG, DESC, CREATFN) NAME##Model,
@@ -207,7 +200,6 @@
   /// A key-value table of use-specified configuration values.
   // TODO: This shouldn't be public.
   ConfigTable Config;
-  AnalysisStores AnalysisStoreOpt = RegionStoreModel;
   AnalysisConstraints AnalysisConstraintsOpt = RangeConstraintsModel;
   AnalysisDiagClients AnalysisDiagOpt = PD_HTML;
   AnalysisPurgeMode AnalysisPurgeOpt = PurgeStmt;
diff --git a/clang/lib/Frontend/CompilerInvocation.cpp b/clang/lib/Frontend/CompilerInvocation.cpp
--- a/clang/lib/Frontend/CompilerInvocation.cpp
+++ b/clang/lib/Frontend/CompilerInvocation.cpp
@@ -816,18 +816,6 @@
 #include "clang/Driver/Options.inc"
 #undef ANALYZER_OPTION_WITH_MARSHALLING
 
-  if (Opts.AnalysisStoreOpt != RegionStoreModel) {
-    switch (Opts.AnalysisStoreOpt) {
-#define ANALYSIS_STORE(NAME, CMDFLAG, DESC, CREATFN)                           \
-  case NAME##Model:                                                            \
-    GenerateArg(Args, OPT_analyzer_store, CMDFLAG, SA);                        \
-    break;
-#include "clang/StaticAnalyzer/Core/Analyses.def"
-    default:
-      llvm_unreachable("Tried to generate unknown analysis store.");
-    }
-  }
-
   if (Opts.AnalysisConstraintsOpt != RangeConstraintsModel) {
     switch (Opts.AnalysisConstraintsOpt) {
 #define ANALYSIS_CONSTRAINTS(NAME, CMDFLAG, DESC, CREATFN)                     \
@@ -915,21 +903,6 @@
 #include "clang/Driver/Options.inc"
 #undef ANALYZER_OPTION_WITH_MARSHALLING
 
-  if (Arg *A = Args.getLastArg(OPT_analyzer_store)) {
-    StringRef Name = A->getValue();
-    AnalysisStores Value = llvm::StringSwitch<AnalysisStores>(Name)
-#define ANALYSIS_STORE(NAME, CMDFLAG, DESC, CREATFN) \
-      .Case(CMDFLAG, NAME##Model)
-#include "clang/StaticAnalyzer/Core/Analyses.def"
-      .Default(NumStores);
-    if (Value == NumStores) {
-      Diags.Report(diag::err_drv_invalid_value)
-        << A->getAsString(Args) << Name;
-    } else {
-      Opts.AnalysisStoreOpt = Value;
-    }
-  }
-
   if (Arg *A = Args.getLastArg(OPT_analyzer_constraints)) {
     StringRef Name = A->getValue();
     AnalysisConstraints Value = llvm::StringSwitch<AnalysisConstraints>(Name)
diff --git a/clang/lib/StaticAnalyzer/Frontend/AnalysisConsumer.cpp b/clang/lib/StaticAnalyzer/Frontend/AnalysisConsumer.cpp
--- a/clang/lib/StaticAnalyzer/Frontend/AnalysisConsumer.cpp
+++ b/clang/lib/StaticAnalyzer/Frontend/AnalysisConsumer.cpp
@@ -171,13 +171,7 @@
     }
 
     // Create the analyzer component creators.
-    switch (Opts->AnalysisStoreOpt) {
-    default:
-      llvm_unreachable("Unknown store manager.");
-#define ANALYSIS_STORE(NAME, CMDFLAG, DESC, CREATEFN)           \
-      case NAME##Model: CreateStoreMgr = CREATEFN; break;
-#include "clang/StaticAnalyzer/Core/Analyses.def"
-    }
+    CreateStoreMgr = &CreateRegionStoreManager;
 
     switch (Opts->AnalysisConstraintsOpt) {
     default: