diff --git a/clang/lib/Format/FormatToken.h b/clang/lib/Format/FormatToken.h
--- a/clang/lib/Format/FormatToken.h
+++ b/clang/lib/Format/FormatToken.h
@@ -928,6 +928,7 @@
     kw___has_include_next = &IdentTable.get("__has_include_next");
 
     kw_mark = &IdentTable.get("mark");
+    kw_region = &IdentTable.get("region");
 
     kw_extend = &IdentTable.get("extend");
     kw_option = &IdentTable.get("option");
@@ -1046,6 +1047,7 @@
 
   // Pragma keywords.
   IdentifierInfo *kw_mark;
+  IdentifierInfo *kw_region;
 
   // Proto keywords.
   IdentifierInfo *kw_extend;
diff --git a/clang/lib/Format/TokenAnnotator.cpp b/clang/lib/Format/TokenAnnotator.cpp
--- a/clang/lib/Format/TokenAnnotator.cpp
+++ b/clang/lib/Format/TokenAnnotator.cpp
@@ -1223,7 +1223,7 @@
   void parsePragma() {
     next(); // Consume "pragma".
     if (CurrentToken &&
-        CurrentToken->isOneOf(Keywords.kw_mark, Keywords.kw_option)) {
+        CurrentToken->isOneOf(Keywords.kw_mark, Keywords.kw_option, Keywords.kw_region)) {
       bool IsMark = CurrentToken->is(Keywords.kw_mark);
       next(); // Consume "mark".
       next(); // Consume first token (so we fix leading whitespace).
diff --git a/clang/test/Format/pragma-region.cpp b/clang/test/Format/pragma-region.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Format/pragma-region.cpp
@@ -0,0 +1,5 @@
+// RUN: grep -Ev "// *[A-Z-]+:" %s | clang-format -style="{ColumnLimit: 0}" \
+// RUN:   | FileCheck -strict-whitespace %s
+
+// CHECK: {{^\#pragma\ region\ TEST\(FOO\ \:\ BAR\)}}
+#pragma region TEST(FOO : BAR)