diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -1308,6 +1308,7 @@
   // If we are offloading to a target via OpenMP we need to include the
   // openmp_wrappers folder which contains alternative system headers.
   if (JA.isDeviceOffloading(Action::OFK_OpenMP) &&
+      !Args.hasArg(options::OPT_nostdinc) &&
       (getToolChain().getTriple().isNVPTX() ||
        getToolChain().getTriple().isAMDGCN())) {
     if (!Args.hasArg(options::OPT_nobuiltininc)) {