diff --git a/llvm/lib/Target/RISCV/RISCVInsertVSETVLI.cpp b/llvm/lib/Target/RISCV/RISCVInsertVSETVLI.cpp
--- a/llvm/lib/Target/RISCV/RISCVInsertVSETVLI.cpp
+++ b/llvm/lib/Target/RISCV/RISCVInsertVSETVLI.cpp
@@ -1218,6 +1218,22 @@
     // predecessors.
     for (MachineBasicBlock &MBB : MF)
       emitVSETVLIs(MBB);
+
+    // Once we're fully done rewriting all the instructions, do a final pass
+    // through to check for VSETVLIs which write to an unused destination.
+    // For the non X0, X0 variant, we can replace the destination register
+    // with X0 to reduce register pressure.  This is really a generic
+    // optimization which can be applied to any dead def (TODO: generalize).
+    for (MachineBasicBlock &MBB : MF) {
+      for (MachineInstr &MI : MBB) {
+        if (MI.getOpcode() == RISCV::PseudoVSETVLI ||
+            MI.getOpcode() == RISCV::PseudoVSETIVLI) {
+          Register VRegDef = MI.getOperand(0).getReg();
+          if (VRegDef != RISCV::X0 && MRI->use_nodbg_empty(VRegDef))
+            MI.getOperand(0).setReg(RISCV::X0);
+        }
+      }
+    }
   }
 
   BlockInfo.clear();
diff --git a/llvm/test/CodeGen/RISCV/rvv/rv32-vsetvli-intrinsics.ll b/llvm/test/CodeGen/RISCV/rvv/rv32-vsetvli-intrinsics.ll
--- a/llvm/test/CodeGen/RISCV/rvv/rv32-vsetvli-intrinsics.ll
+++ b/llvm/test/CodeGen/RISCV/rvv/rv32-vsetvli-intrinsics.ll
@@ -9,7 +9,7 @@
 define void @test_vsetvli_e64mf8(i32 %avl) nounwind {
 ; CHECK-LABEL: test_vsetvli_e64mf8:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetvli a0, a0, e64, mf8, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, mf8, ta, mu
 ; CHECK-NEXT:    ret
   call i32 @llvm.riscv.vsetvli.i32(i32 %avl, i32 3, i32 5)
   ret void
@@ -18,7 +18,7 @@
 define void @test_vsetvli_e8mf2_zero_avl() nounwind {
 ; CHECK-LABEL: test_vsetvli_e8mf2_zero_avl:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetivli a0, 0, e8, mf2, ta, mu
+; CHECK-NEXT:    vsetivli zero, 0, e8, mf2, ta, mu
 ; CHECK-NEXT:    ret
   call i32 @llvm.riscv.vsetvli.i32(i32 0, i32 0, i32 7)
   ret void
@@ -101,7 +101,7 @@
 define <vscale x 4 x i32> @redundant_vsetvli(i32 %avl, <vscale x 4 x i32>* %ptr) nounwind {
 ; CHECK-LABEL: redundant_vsetvli:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e32, m2, ta, mu
 ; CHECK-NEXT:    vle32.v v8, (a1)
 ; CHECK-NEXT:    ret
   %vl = call i32 @llvm.riscv.vsetvli.i32(i32 %avl, i32 2, i32 1)
@@ -117,7 +117,7 @@
 ; CHECK-LABEL: repeated_vsetvli:
 ; CHECK:       # %bb.0:
 ; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
-; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e32, m2, ta, mu
 ; CHECK-NEXT:    vle32.v v8, (a1)
 ; CHECK-NEXT:    ret
   %vl0 = call i32 @llvm.riscv.vsetvli.i32(i32 %avl, i32 2, i32 1)
diff --git a/llvm/test/CodeGen/RISCV/rvv/rv64-vsetvli-intrinsics.ll b/llvm/test/CodeGen/RISCV/rvv/rv64-vsetvli-intrinsics.ll
--- a/llvm/test/CodeGen/RISCV/rvv/rv64-vsetvli-intrinsics.ll
+++ b/llvm/test/CodeGen/RISCV/rvv/rv64-vsetvli-intrinsics.ll
@@ -9,7 +9,7 @@
 define void @test_vsetvli_e8m1(i64 %avl) nounwind {
 ; CHECK-LABEL: test_vsetvli_e8m1:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetvli a0, a0, e8, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e8, m1, ta, mu
 ; CHECK-NEXT:    ret
   call i64 @llvm.riscv.vsetvli.i64(i64 %avl, i64 0, i64 0)
   ret void
@@ -18,7 +18,7 @@
 define void @test_vsetvli_e16mf4(i64 %avl) nounwind {
 ; CHECK-LABEL: test_vsetvli_e16mf4:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetvli a0, a0, e16, mf4, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e16, mf4, ta, mu
 ; CHECK-NEXT:    ret
   call i64 @llvm.riscv.vsetvli.i64(i64 %avl, i64 1, i64 6)
   ret void
@@ -27,7 +27,7 @@
 define void @test_vsetvli_e32mf8_zero_avl() nounwind {
 ; CHECK-LABEL: test_vsetvli_e32mf8_zero_avl:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetivli a0, 0, e16, mf4, ta, mu
+; CHECK-NEXT:    vsetivli zero, 0, e16, mf4, ta, mu
 ; CHECK-NEXT:    ret
   call i64 @llvm.riscv.vsetvli.i64(i64 0, i64 1, i64 6)
   ret void
@@ -119,7 +119,7 @@
 define <vscale x 4 x i32> @redundant_vsetvli(i64 %avl, <vscale x 4 x i32>* %ptr) nounwind {
 ; CHECK-LABEL: redundant_vsetvli:
 ; CHECK:       # %bb.0:
-; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e32, m2, ta, mu
 ; CHECK-NEXT:    vle32.v v8, (a1)
 ; CHECK-NEXT:    ret
   %vl = call i64 @llvm.riscv.vsetvli.i64(i64 %avl, i64 2, i64 1)
@@ -135,7 +135,7 @@
 ; CHECK-LABEL: repeated_vsetvli:
 ; CHECK:       # %bb.0:
 ; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
-; CHECK-NEXT:    vsetvli a0, a0, e32, m2, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e32, m2, ta, mu
 ; CHECK-NEXT:    vle32.v v8, (a1)
 ; CHECK-NEXT:    ret
   %vl0 = call i64 @llvm.riscv.vsetvli.i64(i64 %avl, i64 2, i64 1)
diff --git a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.ll b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.ll
--- a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.ll
+++ b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.ll
@@ -23,7 +23,7 @@
 define <vscale x 1 x double> @test1(i64 %avl, i8 zeroext %cond, <vscale x 1 x double> %a, <vscale x 1 x double> %b) nounwind {
 ; CHECK-LABEL: test1:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    beqz a1, .LBB0_2
 ; CHECK-NEXT:  # %bb.1: # %if.then
 ; CHECK-NEXT:    vfadd.vv v8, v8, v9
@@ -54,7 +54,7 @@
 define <vscale x 1 x double> @test2(i64 %avl, i8 zeroext %cond, <vscale x 1 x double> %a, <vscale x 1 x double> %b) nounwind {
 ; CHECK-LABEL: test2:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    beqz a1, .LBB1_2
 ; CHECK-NEXT:  # %bb.1: # %if.then
 ; CHECK-NEXT:    vfadd.vv v9, v8, v9
@@ -180,7 +180,7 @@
 ; CHECK-LABEL: test5:
 ; CHECK:       # %bb.0: # %entry
 ; CHECK-NEXT:    andi a2, a1, 1
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    bnez a2, .LBB4_3
 ; CHECK-NEXT:  # %bb.1: # %if.else
 ; CHECK-NEXT:    vfsub.vv v9, v8, v9
@@ -244,7 +244,7 @@
 ; CHECK-NEXT:    andi a1, a1, 2
 ; CHECK-NEXT:    beqz a1, .LBB5_4
 ; CHECK-NEXT:  .LBB5_2: # %if.then4
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    lui a0, %hi(.LCPI5_0)
 ; CHECK-NEXT:    addi a0, a0, %lo(.LCPI5_0)
 ; CHECK-NEXT:    vlse64.v v9, (a0), zero
@@ -261,7 +261,7 @@
 ; CHECK-NEXT:    andi a1, a1, 2
 ; CHECK-NEXT:    bnez a1, .LBB5_2
 ; CHECK-NEXT:  .LBB5_4: # %if.else5
-; CHECK-NEXT:    vsetvli a0, a0, e32, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e32, m1, ta, mu
 ; CHECK-NEXT:    lui a0, %hi(.LCPI5_2)
 ; CHECK-NEXT:    addi a0, a0, %lo(.LCPI5_2)
 ; CHECK-NEXT:    vlse32.v v9, (a0), zero
diff --git a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.mir b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.mir
--- a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.mir
+++ b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert-crossbb.mir
@@ -428,7 +428,7 @@
   ; CHECK-NEXT:   [[COPY1:%[0-9]+]]:vr = COPY $v9
   ; CHECK-NEXT:   [[COPY2:%[0-9]+]]:vr = COPY $v8
   ; CHECK-NEXT:   [[COPY3:%[0-9]+]]:gpr = COPY $x10
-  ; CHECK-NEXT:   [[PseudoVSETVLI:%[0-9]+]]:gprnox0 = PseudoVSETVLI [[COPY]], 88 /* e64, m1, ta, mu */, implicit-def $vl, implicit-def $vtype
+  ; CHECK-NEXT:   $x0 = PseudoVSETVLI [[COPY]], 88 /* e64, m1, ta, mu */, implicit-def $vl, implicit-def $vtype
   ; CHECK-NEXT:   [[COPY4:%[0-9]+]]:gpr = COPY $x0
   ; CHECK-NEXT:   BEQ [[COPY3]], [[COPY4]], %bb.2
   ; CHECK-NEXT:   PseudoBR %bb.1
diff --git a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.ll b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.ll
--- a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.ll
+++ b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.ll
@@ -18,7 +18,7 @@
 define <vscale x 1 x double> @test1(i64 %avl, <vscale x 1 x double> %a, <vscale x 1 x double> %b) nounwind {
 ; CHECK-LABEL: test1:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    vfadd.vv v8, v8, v9
 ; CHECK-NEXT:    ret
 entry:
@@ -34,7 +34,7 @@
 define <vscale x 1 x double> @test2(i64 %avl, <vscale x 1 x double> %a, <vscale x 1 x double> %b) nounwind {
 ; CHECK-LABEL: test2:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    vfadd.vv v8, v8, v9
 ; CHECK-NEXT:    ret
 entry:
@@ -50,7 +50,7 @@
 define <vscale x 1 x i64> @test3(i64 %avl, <vscale x 1 x i64> %a, <vscale x 1 x i64>* %b, <vscale x 1 x i1> %c) nounwind {
 ; CHECK-LABEL: test3:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    vle64.v v8, (a1), v0.t
 ; CHECK-NEXT:    ret
 entry:
@@ -67,7 +67,7 @@
 define <vscale x 1 x i64> @test4(i64 %avl, <vscale x 1 x i64> %a, <vscale x 1 x i64>* %b, <vscale x 1 x i1> %c) nounwind {
 ; CHECK-LABEL: test4:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    vle64.v v8, (a1), v0.t
 ; CHECK-NEXT:    ret
 entry:
@@ -85,7 +85,7 @@
 define <vscale x 1 x i1> @test5(<vscale x 1 x i64> %0, <vscale x 1 x i64> %1, <vscale x 1 x i1> %2, i64 %avl) nounwind {
 ; CHECK-LABEL: test5:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetvli a0, a0, e64, m1, ta, mu
+; CHECK-NEXT:    vsetvli zero, a0, e64, m1, ta, mu
 ; CHECK-NEXT:    vmseq.vv v8, v8, v9
 ; CHECK-NEXT:    vmand.mm v0, v8, v0
 ; CHECK-NEXT:    ret
@@ -165,7 +165,7 @@
 define <vscale x 1 x i64> @test8(<vscale x 1 x i64> %a, i64 %b, <vscale x 1 x i1> %mask) nounwind {
 ; CHECK-LABEL: test8:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetivli a1, 6, e64, m1, tu, mu
+; CHECK-NEXT:    vsetivli zero, 6, e64, m1, tu, mu
 ; CHECK-NEXT:    vmv.s.x v8, a0
 ; CHECK-NEXT:    ret
 entry:
@@ -209,7 +209,7 @@
 define <vscale x 1 x double> @test11(<vscale x 1 x double> %a, double %b) nounwind {
 ; CHECK-LABEL: test11:
 ; CHECK:       # %bb.0: # %entry
-; CHECK-NEXT:    vsetivli a0, 6, e64, m1, tu, mu
+; CHECK-NEXT:    vsetivli zero, 6, e64, m1, tu, mu
 ; CHECK-NEXT:    vfmv.s.f v8, fa0
 ; CHECK-NEXT:    ret
 entry:
diff --git a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.mir b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.mir
--- a/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.mir
+++ b/llvm/test/CodeGen/RISCV/rvv/vsetvli-insert.mir
@@ -349,7 +349,7 @@
     ; CHECK-NEXT: [[COPY:%[0-9]+]]:gprnox0 = COPY $x10
     ; CHECK-NEXT: [[COPY1:%[0-9]+]]:vr = COPY $v9
     ; CHECK-NEXT: [[COPY2:%[0-9]+]]:vr = COPY $v8
-    ; CHECK-NEXT: [[PseudoVSETVLI:%[0-9]+]]:gprnox0 = PseudoVSETVLI [[COPY]], 88 /* e64, m1, ta, mu */, implicit-def $vl, implicit-def $vtype
+    ; CHECK-NEXT: $x0 = PseudoVSETVLI [[COPY]], 88 /* e64, m1, ta, mu */, implicit-def $vl, implicit-def $vtype
     ; CHECK-NEXT: [[PseudoVADD_VV_M1_:%[0-9]+]]:vr = PseudoVADD_VV_M1 [[COPY2]], [[COPY1]], $noreg, 6 /* e64 */, implicit $vl, implicit $vtype
     ; CHECK-NEXT: $v8 = COPY [[PseudoVADD_VV_M1_]]
     ; CHECK-NEXT: PseudoRET implicit $v8