diff --git a/llvm/lib/Transforms/Utils/CtorUtils.cpp b/llvm/lib/Transforms/Utils/CtorUtils.cpp
--- a/llvm/lib/Transforms/Utils/CtorUtils.cpp
+++ b/llvm/lib/Transforms/Utils/CtorUtils.cpp
@@ -98,8 +98,9 @@
     if (isa<ConstantPointerNull>(CS->getOperand(1)))
       continue;
 
-    // Must have a function or null ptr.
-    if (!isa<Function>(CS->getOperand(1)))
+    // Can only handle global constructors with no arguments.
+    Function *F = dyn_cast<Function>(CS->getOperand(1));
+    if (!F || F->arg_size() != 0)
       return nullptr;
 
     // Init priority must be standard.
diff --git a/llvm/lib/Transforms/Utils/Evaluator.cpp b/llvm/lib/Transforms/Utils/Evaluator.cpp
--- a/llvm/lib/Transforms/Utils/Evaluator.cpp
+++ b/llvm/lib/Transforms/Utils/Evaluator.cpp
@@ -629,6 +629,8 @@
 /// function.
 bool Evaluator::EvaluateFunction(Function *F, Constant *&RetVal,
                                  const SmallVectorImpl<Constant*> &ActualArgs) {
+  assert(ActualArgs.size() == F->arg_size() && "wrong number of arguments");
+
   // Check to see if this function is already executing (recursion).  If so,
   // bail out.  TODO: we might want to accept limited recursion.
   if (is_contained(CallStack, F))
diff --git a/llvm/test/Transforms/GlobalOpt/global-constructor-opaque-ptr.ll b/llvm/test/Transforms/GlobalOpt/global-constructor-opaque-ptr.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GlobalOpt/global-constructor-opaque-ptr.ll
@@ -0,0 +1,14 @@
+; RUN: opt -passes=globalopt -S < %s | FileCheck %s
+
+; CHECK: @f1
+; CHECK: @f2
+
+@llvm.global_ctors = appending global [2 x { i32, ptr, ptr }] [{ i32, ptr, ptr } { i32 65535, ptr @f1, ptr null }, { i32, ptr, ptr } { i32 65535, ptr @f2, ptr null }]
+
+define void @f1(i32 %args) {
+  ret void
+}
+
+define i32 @f2(i32 %args) {
+  ret i32 0
+}