diff --git a/llvm/lib/Transforms/IPO/SampleProfile.cpp b/llvm/lib/Transforms/IPO/SampleProfile.cpp
--- a/llvm/lib/Transforms/IPO/SampleProfile.cpp
+++ b/llvm/lib/Transforms/IPO/SampleProfile.cpp
@@ -74,7 +74,6 @@
 #include "llvm/Transforms/Instrumentation.h"
 #include "llvm/Transforms/Utils/CallPromotionUtils.h"
 #include "llvm/Transforms/Utils/Cloning.h"
-#include "llvm/Transforms/Utils/MisExpect.h"
 #include "llvm/Transforms/Utils/SampleProfileInference.h"
 #include "llvm/Transforms/Utils/SampleProfileLoaderBaseImpl.h"
 #include "llvm/Transforms/Utils/SampleProfileLoaderBaseUtil.h"
@@ -1741,7 +1740,10 @@
       }
     }
 
-    misexpect::checkExpectAnnotations(*TI, Weights, /*IsFrontend=*/false);
+    // FIXME: Re-enable for sample profiling after investigating why the sum
+    // of branch weights can be 0
+    //
+    // misexpect::checkExpectAnnotations(*TI, Weights, /*IsFrontend=*/false);
 
     uint64_t TempWeight;
     // Only set weights if there is at least one non-zero weight.
diff --git a/llvm/lib/Transforms/Utils/MisExpect.cpp b/llvm/lib/Transforms/Utils/MisExpect.cpp
--- a/llvm/lib/Transforms/Utils/MisExpect.cpp
+++ b/llvm/lib/Transforms/Utils/MisExpect.cpp
@@ -185,8 +185,11 @@
   uint64_t TotalBranchWeight =
       LikelyBranchWeight + (UnlikelyBranchWeight * NumUnlikelyTargets);
 
-  assert((TotalBranchWeight >= LikelyBranchWeight) && (TotalBranchWeight > 0) &&
-         "TotalBranchWeight is less than the Likely branch weight");
+  // We cannot calculate branch probability if either of these invariants aren't
+  // met. However, MisExpect diagnostics should not prevent code from compiling,
+  // so we simply forgo emitting diagnostics here, and return early.
+  if ((TotalBranchWeight == 0) || (TotalBranchWeight <= LikelyBranchWeight))
+    return;
 
   // To determine our threshold value we need to obtain the branch probability
   // for the weights added by llvm.expect and use that proportion to calculate