diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_linux.cpp b/compiler-rt/lib/sanitizer_common/sanitizer_linux.cpp
--- a/compiler-rt/lib/sanitizer_common/sanitizer_linux.cpp
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_linux.cpp
@@ -233,7 +233,7 @@
 }
 
 uptr internal_open(const char *filename, int flags) {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
   return internal_syscall(SYSCALL(openat), AT_FDCWD, (uptr)filename, flags);
 #else
   return internal_syscall(SYSCALL(open), (uptr)filename, flags);
@@ -241,7 +241,7 @@
 }
 
 uptr internal_open(const char *filename, int flags, u32 mode) {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
   return internal_syscall(SYSCALL(openat), AT_FDCWD, (uptr)filename, flags,
                           mode);
 #else
@@ -342,50 +342,46 @@
 uptr internal_stat(const char *path, void *buf) {
 #if SANITIZER_FREEBSD
   return internal_syscall(SYSCALL(fstatat), AT_FDCWD, (uptr)path, (uptr)buf, 0);
-#elif SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    elif SANITIZER_LINUX
+#      if SANITIZER_WORDSIZE == 64
   return internal_syscall(SYSCALL(newfstatat), AT_FDCWD, (uptr)path, (uptr)buf,
                           0);
-#elif SANITIZER_LINUX_USES_64BIT_SYSCALLS
-# if defined(__mips64)
-  // For mips64, stat syscall fills buffer in the format of kernel_stat
-  struct kernel_stat kbuf;
-  int res = internal_syscall(SYSCALL(stat), path, &kbuf);
-  kernel_stat_to_stat(&kbuf, (struct stat *)buf);
+#      else
+  struct stat64 buf64;
+  int res = internal_syscall(SYSCALL(fstatat64), AT_FDCWD, (uptr)path,
+                             (uptr)&buf64, 0);
+  stat64_to_stat(&buf64, (struct stat *)buf);
   return res;
-# else
-  return internal_syscall(SYSCALL(stat), (uptr)path, (uptr)buf);
-# endif
-#else
+#      endif
+#    else
   struct stat64 buf64;
   int res = internal_syscall(SYSCALL(stat64), path, &buf64);
   stat64_to_stat(&buf64, (struct stat *)buf);
   return res;
-#endif
+#    endif
 }
 
 uptr internal_lstat(const char *path, void *buf) {
 #if SANITIZER_FREEBSD
   return internal_syscall(SYSCALL(fstatat), AT_FDCWD, (uptr)path, (uptr)buf,
                           AT_SYMLINK_NOFOLLOW);
-#elif SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    elif SANITIZER_LINUX
+#      if defined(_LP64)
   return internal_syscall(SYSCALL(newfstatat), AT_FDCWD, (uptr)path, (uptr)buf,
                           AT_SYMLINK_NOFOLLOW);
-#elif SANITIZER_LINUX_USES_64BIT_SYSCALLS
-# if SANITIZER_MIPS64
-  // For mips64, lstat syscall fills buffer in the format of kernel_stat
-  struct kernel_stat kbuf;
-  int res = internal_syscall(SYSCALL(lstat), path, &kbuf);
-  kernel_stat_to_stat(&kbuf, (struct stat *)buf);
+#      else
+  struct stat64 buf64;
+  int res = internal_syscall(SYSCALL(fstatat64), AT_FDCWD, (uptr)path,
+                             (uptr)&buf64, AT_SYMLINK_NOFOLLOW);
+  stat64_to_stat(&buf64, (struct stat *)buf);
   return res;
-# else
-  return internal_syscall(SYSCALL(lstat), (uptr)path, (uptr)buf);
-# endif
-#else
+#      endif
+#    else
   struct stat64 buf64;
   int res = internal_syscall(SYSCALL(lstat64), path, &buf64);
   stat64_to_stat(&buf64, (struct stat *)buf);
   return res;
-#endif
+#    endif
 }
 
 uptr internal_fstat(fd_t fd, void *buf) {
@@ -419,7 +415,7 @@
 }
 
 uptr internal_dup2(int oldfd, int newfd) {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
   return internal_syscall(SYSCALL(dup3), oldfd, newfd, 0);
 #else
   return internal_syscall(SYSCALL(dup2), oldfd, newfd);
@@ -427,7 +423,7 @@
 }
 
 uptr internal_readlink(const char *path, char *buf, uptr bufsize) {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
   return internal_syscall(SYSCALL(readlinkat), AT_FDCWD, (uptr)path, (uptr)buf,
                           bufsize);
 #else
@@ -436,7 +432,7 @@
 }
 
 uptr internal_unlink(const char *path) {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
   return internal_syscall(SYSCALL(unlinkat), AT_FDCWD, (uptr)path, 0);
 #else
   return internal_syscall(SYSCALL(unlink), (uptr)path);
@@ -447,12 +443,12 @@
 #if defined(__riscv) && defined(__linux__)
   return internal_syscall(SYSCALL(renameat2), AT_FDCWD, (uptr)oldpath, AT_FDCWD,
                           (uptr)newpath, 0);
-#elif SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    elif SANITIZER_LINUX
   return internal_syscall(SYSCALL(renameat), AT_FDCWD, (uptr)oldpath, AT_FDCWD,
                           (uptr)newpath);
-#else
+#    else
   return internal_syscall(SYSCALL(rename), (uptr)oldpath, (uptr)newpath);
-#endif
+#    endif
 }
 
 uptr internal_sched_yield() {
@@ -489,11 +485,7 @@
   if (ShouldMockFailureToOpen(filename))
     return false;
   struct stat st;
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
-  if (internal_syscall(SYSCALL(newfstatat), AT_FDCWD, filename, &st, 0))
-#else
   if (internal_stat(filename, &st))
-#endif
     return false;
   // Sanity check: filename is a regular file.
   return S_ISREG(st.st_mode);
@@ -501,11 +493,7 @@
 
 bool DirExists(const char *path) {
   struct stat st;
-#  if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
-  if (internal_syscall(SYSCALL(newfstatat), AT_FDCWD, path, &st, 0))
-#  else
   if (internal_stat(path, &st))
-#  endif
     return false;
   return S_ISDIR(st.st_mode);
 }
@@ -709,17 +697,17 @@
 // Not used
 #else
 struct linux_dirent {
-#if SANITIZER_X32 || defined(__aarch64__) || SANITIZER_RISCV64
+#    if SANITIZER_X32 || SANITIZER_LINUX
   u64 d_ino;
   u64 d_off;
-#else
+#    else
   unsigned long      d_ino;
   unsigned long      d_off;
-#endif
+#    endif
   unsigned short     d_reclen;
-#if defined(__aarch64__) || SANITIZER_RISCV64
+#    if SANITIZER_LINUX
   unsigned char      d_type;
-#endif
+#    endif
   char               d_name[256];
 };
 #endif
@@ -755,11 +743,11 @@
 uptr internal_getdents(fd_t fd, struct linux_dirent *dirp, unsigned int count) {
 #if SANITIZER_FREEBSD
   return internal_syscall(SYSCALL(getdirentries), fd, (uptr)dirp, count, NULL);
-#elif SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    elif SANITIZER_LINUX
   return internal_syscall(SYSCALL(getdents64), fd, (uptr)dirp, count);
-#else
+#    else
   return internal_syscall(SYSCALL(getdents), fd, (uptr)dirp, count);
-#endif
+#    endif
 }
 
 uptr internal_lseek(fd_t fd, OFF_T offset, int whence) {
@@ -777,11 +765,15 @@
 }
 
 int internal_fork() {
-#if SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
+#    if SANITIZER_LINUX
+#      if SANITIZER_S390
+  return internal_syscall(SYSCALL(clone), 0, SIGCHLD);
+#      else
   return internal_syscall(SYSCALL(clone), SIGCHLD, 0);
-#else
+#      endif
+#    else
   return internal_syscall(SYSCALL(fork));
-#endif
+#    endif
 }
 
 #if SANITIZER_FREEBSD
diff --git a/compiler-rt/lib/sanitizer_common/sanitizer_platform.h b/compiler-rt/lib/sanitizer_common/sanitizer_platform.h
--- a/compiler-rt/lib/sanitizer_common/sanitizer_platform.h
+++ b/compiler-rt/lib/sanitizer_common/sanitizer_platform.h
@@ -298,18 +298,6 @@
 #  define SANITIZER_SIGN_EXTENDED_ADDRESSES 0
 #endif
 
-// The AArch64 and RISC-V linux ports use the canonical syscall set as
-// mandated by the upstream linux community for all new ports. Other ports
-// may still use legacy syscalls.
-#ifndef SANITIZER_USES_CANONICAL_LINUX_SYSCALLS
-#  if (defined(__aarch64__) || defined(__riscv) || defined(__hexagon__)) && \
-      SANITIZER_LINUX
-#    define SANITIZER_USES_CANONICAL_LINUX_SYSCALLS 1
-#  else
-#    define SANITIZER_USES_CANONICAL_LINUX_SYSCALLS 0
-#  endif
-#endif
-
 // udi16 syscalls can only be used when the following conditions are
 // met:
 // * target is one of arm32, x86-32, sparc32, sh or m68k