Index: llvm/test/tools/llvm-reduce/mir/preserve-reg-hints.mir
===================================================================
--- llvm/test/tools/llvm-reduce/mir/preserve-reg-hints.mir
+++ llvm/test/tools/llvm-reduce/mir/preserve-reg-hints.mir
@@ -1,5 +1,5 @@
 # REQUIRES: amdgpu-registered-target
-# RUN: llvm-reduce -mtriple=amdgcn-amd-amdhsa --test FileCheck --test-arg --check-prefix=CHECK-INTERESTINGNESS --test-arg %s --test-arg --input-file %s -o %t 2> %t.log
+# RUN: llvm-reduce -mtriple=amdgcn-amd-amdhsa --delta-passes=instructions --test FileCheck --test-arg --check-prefix=CHECK-INTERESTINGNESS --test-arg %s --test-arg --input-file %s -o %t 2> %t.log
 # RUN: FileCheck --match-full-lines --check-prefix=RESULT %s < %t
 
 # CHECK-INTERESTINGNESS: S_NOP 0
Index: llvm/test/tools/llvm-reduce/mir/reduce-register-hints.mir
===================================================================
--- /dev/null
+++ llvm/test/tools/llvm-reduce/mir/reduce-register-hints.mir
@@ -0,0 +1,38 @@
+# REQUIRES: amdgpu-registered-target
+# RUN: llvm-reduce -simplify-mir --delta-passes=register-hints -mtriple=amdgcn-amd-amdhsa --test FileCheck --test-arg --check-prefix=CHECK-INTERESTINGNESS --test-arg %s --test-arg --input-file %s -o %t 2> %t.log
+# RUN: FileCheck --check-prefix=RESULT %s < %t
+
+# CHECK-INTERESTINGNESS: - { id: 0, class: vgpr_32, preferred-register: '$vgpr0' }
+# CHECK-INTERESTINGNESS: - { id: 2, class: vgpr_32, preferred-register: '%1' }
+# CHECK-INTERESTINGNESS-COUNT-5: V_MOV_B32
+
+# RESULT: registers:
+# RESULT-NEXT: - { id: 0, class: vgpr_32, preferred-register: '$vgpr0' }
+# RESULT-NEXT: - { id: 1, class: vgpr_32 }
+# RESULT-NEXT: - { id: 2, class: vgpr_32, preferred-register: '%1' }
+# RESULT-NEXT: - { id: 3, class: vgpr_32 }
+# RESULT-NEXT: - { id: 4, class: vgpr_32 }
+
+---
+name: func
+tracksRegLiveness: true
+registers:
+  - { id: 0, class: vgpr_32, preferred-register: '$vgpr0' }
+  - { id: 1, class: vgpr_32, preferred-register: '' }
+  - { id: 2, class: vgpr_32, preferred-register: '%1' }
+  - { id: 3, class: vgpr_32, preferred-register: '%4' }
+  - { id: 4, class: vgpr_32, preferred-register: '%3' }
+body:             |
+  bb.0:
+    liveins: $vgpr0, $vgpr1
+
+    S_WAITCNT 0
+    %0:vgpr_32 = V_MOV_B32_e32 0, implicit $exec
+    %1:vgpr_32 = V_MOV_B32_e32 1, implicit $exec
+    %2:vgpr_32 = V_MOV_B32_e32 2, implicit $exec
+    %3:vgpr_32 = V_MOV_B32_e32 3, implicit $exec
+    %4:vgpr_32 = V_MOV_B32_e32 4, implicit $exec
+    S_NOP 0
+    S_ENDPGM 0, implicit %0, implicit %1, implicit %2, implicit %3, implicit %4
+...
+
Index: llvm/tools/llvm-reduce/CMakeLists.txt
===================================================================
--- llvm/tools/llvm-reduce/CMakeLists.txt
+++ llvm/tools/llvm-reduce/CMakeLists.txt
@@ -41,6 +41,7 @@
   deltas/ReduceInstructionsMIR.cpp
   deltas/ReduceInstructionFlagsMIR.cpp
   deltas/ReduceIRReferences.cpp
+  deltas/ReduceVirtualRegisters.cpp
   llvm-reduce.cpp
 
   DEPENDS
Index: llvm/tools/llvm-reduce/DeltaManager.cpp
===================================================================
--- llvm/tools/llvm-reduce/DeltaManager.cpp
+++ llvm/tools/llvm-reduce/DeltaManager.cpp
@@ -35,6 +35,7 @@
 #include "deltas/ReduceOperandsSkip.h"
 #include "deltas/ReduceOperandsToArgs.h"
 #include "deltas/ReduceSpecialGlobals.h"
+#include "deltas/ReduceVirtualRegisters.h"
 #include "llvm/Support/CommandLine.h"
 
 using namespace llvm;
@@ -74,7 +75,8 @@
              reduceIRInstructionReferencesDeltaPass)                           \
   DELTA_PASS("ir-block-references", reduceIRBlockReferencesDeltaPass)          \
   DELTA_PASS("ir-function-references", reduceIRFunctionReferencesDeltaPass)    \
-  DELTA_PASS("instruction-flags", reduceInstructionFlagsMIRDeltaPass)
+  DELTA_PASS("instruction-flags", reduceInstructionFlagsMIRDeltaPass)          \
+  DELTA_PASS("register-hints", reduceVirtualRegisterHintsDeltaPass)
 
 static void runAllDeltaPasses(TestRunner &Tester) {
 #define DELTA_PASS(NAME, FUNC) FUNC(Tester);
Index: llvm/tools/llvm-reduce/ReducerWorkItem.cpp
===================================================================
--- llvm/tools/llvm-reduce/ReducerWorkItem.cpp
+++ llvm/tools/llvm-reduce/ReducerWorkItem.cpp
@@ -484,6 +484,12 @@
   // Add in the block count.
   Score += 2 * MF.size();
 
+  const MachineRegisterInfo &MRI = MF.getRegInfo();
+  for (unsigned I = 0, E = MRI.getNumVirtRegs(); I != E; ++I) {
+    Register Reg = Register::index2VirtReg(I);
+    Score += MRI.getRegAllocationHints(Reg).second.size();
+  }
+
   for (const MachineBasicBlock &MBB : MF) {
     for (const MachineInstr &MI : MBB) {
       const unsigned Opc = MI.getOpcode();
Index: llvm/tools/llvm-reduce/deltas/ReduceVirtualRegisters.h
===================================================================
--- /dev/null
+++ llvm/tools/llvm-reduce/deltas/ReduceVirtualRegisters.h
@@ -0,0 +1,25 @@
+//===- ReduceVirtualRegisters.h  - Specialized Delta Pass -------*- c++ -*-===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+//
+// This file implements a function which calls the Generic Delta pass in order
+// to simplify virtual register information.
+//
+//===----------------------------------------------------------------------===//
+
+#ifndef LLVM_TOOLS_LLVM_REDUCE_DELTAS_REDUCEVIRTUALREGISTERS_H
+#define LLVM_TOOLS_LLVM_REDUCE_DELTAS_REDUCEVIRTUALREGISTERS_H
+
+namespace llvm {
+class TestRunner;
+
+/// Remove register allocation hints from virtual registes.
+void reduceVirtualRegisterHintsDeltaPass(TestRunner &Test);
+
+} // namespace llvm
+
+#endif
Index: llvm/tools/llvm-reduce/deltas/ReduceVirtualRegisters.cpp
===================================================================
--- /dev/null
+++ llvm/tools/llvm-reduce/deltas/ReduceVirtualRegisters.cpp
@@ -0,0 +1,46 @@
+//===- ReduceVirtualRegisters.cpp - Specialized Delta Pass ----------------===//
+//
+// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
+// See https://llvm.org/LICENSE.txt for license information.
+// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
+//
+//===----------------------------------------------------------------------===//
+//
+// This file implements a function which calls the Generic Delta pass in order
+// to simplify virtual registers in MIR.
+//
+//===----------------------------------------------------------------------===//
+
+#include "ReduceVirtualRegisters.h"
+#include "Delta.h"
+#include "llvm/CodeGen/MachineRegisterInfo.h"
+
+using namespace llvm;
+
+static void dropRegisterHintsFromFunction(Oracle &O, MachineFunction &MF) {
+  MachineRegisterInfo &MRI = MF.getRegInfo();
+  for (unsigned I = 0, E = MRI.getNumVirtRegs(); I != E; ++I) {
+    Register Reg = Register::index2VirtReg(I);
+
+    const std::pair<Register, SmallVector<Register, 4>> &Hints =
+        MRI.getRegAllocationHints(Reg);
+    if (Hints.second.empty())
+      continue;
+
+    if (!O.shouldKeep())
+      MRI.clearSimpleHint(Reg);
+  }
+}
+
+static void dropRegisterHintsFromFunctions(Oracle &O,
+                                           ReducerWorkItem &WorkItem) {
+  for (const Function &F : WorkItem.getModule()) {
+    if (auto *MF = WorkItem.MMI->getMachineFunction(F))
+      dropRegisterHintsFromFunction(O, *MF);
+  }
+}
+
+void llvm::reduceVirtualRegisterHintsDeltaPass(TestRunner &Test) {
+  outs() << "*** Reducing virtual register hints from functions...\n";
+  runDeltaPass(Test, dropRegisterHintsFromFunctions);
+}