Index: llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
===================================================================
--- llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
+++ llvm/lib/Target/AMDGPU/SIInstrInfo.cpp
@@ -8083,10 +8083,10 @@
   const int MaxInstScan = 20;
   int NumInst = 0;
 
-  // Stop scan when we have seen all the uses.
-  for (auto I = std::next(DefMI.getIterator()); ; ++I) {
-    assert(I != DefBB->end());
+  MachineBasicBlock::const_iterator E = DefBB->end();
 
+  // Stop scan when we have seen all the uses.
+  for (auto I = std::next(DefMI.getIterator()); I != E; ++I) {
     if (I->isDebugInstr())
       continue;
 
@@ -8109,6 +8109,8 @@
         return true;
     }
   }
+
+  return false;
 }
 
 MachineInstr *SIInstrInfo::createPHIDestinationCopy(
Index: llvm/test/CodeGen/AMDGPU/dpp_combine.mir
===================================================================
--- llvm/test/CodeGen/AMDGPU/dpp_combine.mir
+++ llvm/test/CodeGen/AMDGPU/dpp_combine.mir
@@ -883,3 +883,58 @@
     %5:vgpr_32 = V_ADD_CO_U32_e32 %4.sub0, %4.sub0, implicit-def $vcc, implicit $exec
     %6:vgpr_32 = V_ADDC_U32_e32 %4.sub1, %4.sub1, implicit-def $vcc, implicit $vcc, implicit $exec
 ...
+
+# execMayBeModifiedBeforeAnyUse used to assert if the queried
+# V_MOV_B32_dpp was the last instruction in the block.
+---
+name:            mov_dpp_last_block_inst
+tracksRegLiveness: true
+body:             |
+  ; GCN-LABEL: name: mov_dpp_last_block_inst
+  ; GCN: bb.0:
+  ; GCN-NEXT:   successors: %bb.1(0x80000000)
+  ; GCN-NEXT:   liveins: $vgpr0, $sgpr4_sgpr5, $sgpr6_sgpr7, $sgpr8
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT:   [[COPY:%[0-9]+]]:sgpr_32 = COPY $sgpr8
+  ; GCN-NEXT:   [[DEF:%[0-9]+]]:vgpr_32 = IMPLICIT_DEF
+  ; GCN-NEXT:   [[DEF1:%[0-9]+]]:sreg_32 = IMPLICIT_DEF
+  ; GCN-NEXT:   [[DEF2:%[0-9]+]]:sreg_64_xexec = IMPLICIT_DEF
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT: bb.1:
+  ; GCN-NEXT:   successors: %bb.2(0x80000000)
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT:   [[PHI:%[0-9]+]]:vgpr_32 = PHI [[DEF]], %bb.0, %5, %bb.2
+  ; GCN-NEXT:   [[V_MOV_B32_dpp:%[0-9]+]]:vgpr_32 = V_MOV_B32_dpp [[DEF]], [[PHI]], 323, 15, 15, 0, implicit $exec
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT: bb.2:
+  ; GCN-NEXT:   successors: %bb.1(0x40000000), %bb.3(0x40000000)
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT:   [[V_CNDMASK_B32_e64_:%[0-9]+]]:vgpr_32 = V_CNDMASK_B32_e64 0, 0, 0, 1, [[DEF2]], implicit $exec
+  ; GCN-NEXT:   V_CMP_NE_U32_e32 1, [[V_CNDMASK_B32_e64_]], implicit-def $vcc, implicit $exec
+  ; GCN-NEXT:   S_CBRANCH_VCCNZ %bb.1, implicit $vcc
+  ; GCN-NEXT:   S_BRANCH %bb.3
+  ; GCN-NEXT: {{  $}}
+  ; GCN-NEXT: bb.3:
+  ; GCN-NEXT:   S_ENDPGM 0
+  bb.0:
+    liveins: $vgpr0, $sgpr4_sgpr5, $sgpr6_sgpr7, $sgpr8
+
+    %0:sgpr_32 = COPY $sgpr8
+    %1:vgpr_32 = IMPLICIT_DEF
+    %2:sreg_32 = IMPLICIT_DEF
+    %3:sreg_64_xexec = IMPLICIT_DEF
+
+  bb.1:
+    %4:vgpr_32 = PHI %1, %bb.0, %5, %bb.2
+    %5:vgpr_32 = V_MOV_B32_dpp %1, %4, 323, 15, 15, 0, implicit $exec
+
+  bb.2:
+    %6:vgpr_32 = V_CNDMASK_B32_e64 0, 0, 0, 1, %3, implicit $exec
+    V_CMP_NE_U32_e32 1, %6, implicit-def $vcc, implicit $exec
+    S_CBRANCH_VCCNZ %bb.1, implicit $vcc
+    S_BRANCH %bb.3
+
+  bb.3:
+    S_ENDPGM 0
+
+...