diff --git a/openmp/libomptarget/plugins/cuda/src/rtl.cpp b/openmp/libomptarget/plugins/cuda/src/rtl.cpp
--- a/openmp/libomptarget/plugins/cuda/src/rtl.cpp
+++ b/openmp/libomptarget/plugins/cuda/src/rtl.cpp
@@ -1047,6 +1047,23 @@
         return memcpyDtoD(SrcPtr, DstPtr, Size, Stream);
       }
 
+      // Switch to destination context to enable peer access.
+      if (setContext(DstDevId) != OFFLOAD_SUCCESS)
+        return OFFLOAD_FAIL;
+
+      Err = cuCtxEnablePeerAccess(DeviceData[SrcDevId].Context, 0);
+      if (Err != CUDA_SUCCESS) {
+        REPORT("Error returned from cuCtxEnablePeerAccess. src = %" PRId32
+               ", dst = %" PRId32 "\n",
+               SrcDevId, DstDevId);
+        CUDA_ERR_STRING(Err);
+        return memcpyDtoD(SrcPtr, DstPtr, Size, Stream);
+      }
+
+      // Switch back to source context to issue memcpy.
+      if (setContext(SrcDevId) != OFFLOAD_SUCCESS)
+        return OFFLOAD_FAIL;
+
       Err = cuMemcpyPeerAsync((CUdeviceptr)DstPtr, DeviceData[DstDevId].Context,
                               (CUdeviceptr)SrcPtr, DeviceData[SrcDevId].Context,
                               Size, Stream);
@@ -1464,7 +1481,7 @@
     return OFFLOAD_SUCCESS;
   }
 
-  int setContext(int DeviceId) {
+  int setContext(int DeviceId) const {
     assert(InitializedFlags[DeviceId] && "Device is not initialized");
 
     CUresult Err = cuCtxSetCurrent(DeviceData[DeviceId].Context);
@@ -1597,9 +1614,11 @@
                                       __tgt_async_info *AsyncInfo) {
   assert(DeviceRTL.isValidDeviceId(src_dev_id) && "src_dev_id is invalid");
   assert(DeviceRTL.isValidDeviceId(dst_dev_id) && "dst_dev_id is invalid");
+
   assert(AsyncInfo && "AsyncInfo is nullptr");
-  // NOTE: We don't need to set context for data exchange as the device contexts
-  // are passed to CUDA function directly.
+  if (DeviceRTL.setContext(src_dev_id) != OFFLOAD_SUCCESS)
+    return OFFLOAD_FAIL;
+
   return DeviceRTL.dataExchange(src_dev_id, src_ptr, dst_dev_id, dst_ptr, size,
                                 AsyncInfo);
 }