diff --git a/clang/include/clang/AST/ASTContext.h b/clang/include/clang/AST/ASTContext.h
--- a/clang/include/clang/AST/ASTContext.h
+++ b/clang/include/clang/AST/ASTContext.h
@@ -677,6 +677,9 @@
     ~CUDAConstantEvalContextRAII() { Ctx.CUDAConstantEvalCtx = SavedCtx; }
   };
 
+  /// Current CUDA name mangling is for device name in host compilation.
+  bool CUDAMangleDeviceNameInHostCompilation = false;
+
   /// Returns the dynamic AST node parent map context.
   ParentMapContext &getParentMapContext();
 
diff --git a/clang/lib/AST/ASTContext.cpp b/clang/lib/AST/ASTContext.cpp
--- a/clang/lib/AST/ASTContext.cpp
+++ b/clang/lib/AST/ASTContext.cpp
@@ -11762,7 +11762,14 @@
 
 unsigned ASTContext::getManglingNumber(const NamedDecl *ND) const {
   auto I = MangleNumbers.find(ND);
-  return I != MangleNumbers.end() ? I->second : 1;
+  unsigned Res = I != MangleNumbers.end() ? I->second : 1;
+  if (!LangOpts.CUDA || LangOpts.CUDAIsDevice)
+    return Res;
+
+  // CUDA/HIP host compilation encodes host and device mangling numbers
+  // as lower and upper half of 32 bit integer.
+  Res = CUDAMangleDeviceNameInHostCompilation ? Res >> 16 : Res & 0xFFFF;
+  return Res > 1 ? Res : 1;
 }
 
 void ASTContext::setStaticLocalNumber(const VarDecl *VD, unsigned Number) {
diff --git a/clang/lib/AST/MicrosoftCXXABI.cpp b/clang/lib/AST/MicrosoftCXXABI.cpp
--- a/clang/lib/AST/MicrosoftCXXABI.cpp
+++ b/clang/lib/AST/MicrosoftCXXABI.cpp
@@ -76,6 +76,20 @@
   unsigned getDeviceManglingNumber(const CXXMethodDecl *CallOperator) override {
     return DeviceCtx->getManglingNumber(CallOperator);
   }
+
+  unsigned getManglingNumber(const TagDecl *TD,
+                             unsigned MSLocalManglingNumber) override {
+    unsigned DeviceN = DeviceCtx->getManglingNumber(TD, MSLocalManglingNumber);
+    unsigned HostN =
+        MicrosoftNumberingContext::getManglingNumber(TD, MSLocalManglingNumber);
+    if (DeviceN > 0xFFFF || HostN > 0xFFFF) {
+      DiagnosticsEngine &Diags = TD->getASTContext().getDiagnostics();
+      unsigned DiagID = Diags.getCustomDiagID(
+          DiagnosticsEngine::Error, "Mangling number exceeds limit (65535)");
+      Diags.Report(TD->getLocation(), DiagID);
+    }
+    return (DeviceN << 16) | HostN;
+  }
 };
 
 class MSSYCLNumberingContext : public MicrosoftNumberingContext {
diff --git a/clang/lib/CodeGen/CGCUDANV.cpp b/clang/lib/CodeGen/CGCUDANV.cpp
--- a/clang/lib/CodeGen/CGCUDANV.cpp
+++ b/clang/lib/CodeGen/CGCUDANV.cpp
@@ -24,6 +24,7 @@
 #include "llvm/IR/DerivedTypes.h"
 #include "llvm/IR/ReplaceConstant.h"
 #include "llvm/Support/Format.h"
+#include "llvm/Support/SaveAndRestore.h"
 
 using namespace clang;
 using namespace CodeGen;
@@ -260,6 +261,8 @@
 }
 
 std::string CGNVCUDARuntime::getDeviceSideName(const NamedDecl *ND) {
+  llvm::SaveAndRestore<bool> MangleAsDevice(
+      CGM.getContext().CUDAMangleDeviceNameInHostCompilation, true);
   GlobalDecl GD;
   // D could be either a kernel or a variable.
   if (auto *FD = dyn_cast<FunctionDecl>(ND))
diff --git a/clang/test/CodeGenCUDA/struct-mangling-number.cu b/clang/test/CodeGenCUDA/struct-mangling-number.cu
new file mode 100644
--- /dev/null
+++ b/clang/test/CodeGenCUDA/struct-mangling-number.cu
@@ -0,0 +1,68 @@
+// RUN: %clang_cc1 -emit-llvm -o - -aux-triple x86_64-pc-windows-msvc \
+// RUN:   -fms-extensions -triple amdgcn-amd-amdhsa \
+// RUN:   -target-cpu gfx1030 -fcuda-is-device -x hip %s \
+// RUN:   | FileCheck -check-prefix=DEV %s
+
+// RUN: %clang_cc1 -emit-llvm -o - -triple x86_64-pc-windows-msvc \
+// RUN:   -fms-extensions -aux-triple amdgcn-amd-amdhsa \
+// RUN:   -aux-target-cpu gfx1030 -x hip %s \
+// RUN:   | FileCheck -check-prefix=HOST %s
+
+// RUN: %clang_cc1 -emit-llvm -o - -triple x86_64-pc-windows-msvc \
+// RUN:   -fms-extensions -aux-triple amdgcn-amd-amdhsa \
+// RUN:   -aux-target-cpu gfx1030 -x hip %s \
+// RUN:   | FileCheck -check-prefix=HOST-NEG %s
+
+// RUN: %clang_cc1 -emit-llvm -o - -triple x86_64-pc-windows-msvc \
+// RUN:   -fms-extensions -x c++ %s \
+// RUN:   | FileCheck -check-prefix=CPP %s
+
+#if __HIP__
+#include "Inputs/cuda.h"
+#endif
+
+// Check local struct 'Op' uses Itanium mangling number instead of MSVC mangling
+// number in device side name mangling. It is the same in device and host
+// compilation.
+
+// DEV: define amdgpu_kernel void @_Z6kernelIZN4TestIiE3runEvE2OpEvv(
+
+// HOST-DAG:     @{{.*}} = {{.*}}c"_Z6kernelIZN4TestIiE3runEvE2OpEvv\00"
+
+// HOST-NEG-NOT: @{{.*}} = {{.*}}c"_Z6kernelIZN4TestIiE3runEvE2Op_1Evv\00"
+#if __HIP__
+template<typename T>
+__attribute__((global)) void kernel()
+{
+}
+#endif
+
+// Check local struct 'Op' uses MSVC mangling number in host function name mangling.
+// It is the same when compiled as HIP or C++ program.
+
+// HOST-DAG: call void @"??$fun@UOp@?2??run@?$Test@H@@QEAAXXZ@@@YAXXZ"()
+// CPP:      call void @"??$fun@UOp@?2??run@?$Test@H@@QEAAXXZ@@@YAXXZ"()
+template<typename T>
+void fun()
+{
+}
+
+template <typename T>
+class Test {
+public:
+  void run()
+  {
+    struct Op
+    {
+    };
+#if __HIP__
+    kernel<Op><<<1, 1>>>();
+#endif
+    fun<Op>();
+  }
+};
+
+int main() {
+  Test<int> A;
+  A.run();
+}