diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -2406,7 +2406,8 @@
   if (!CompilationDatabase) {
     std::error_code EC;
     auto File = std::make_unique<llvm::raw_fd_ostream>(
-        Filename, EC, llvm::sys::fs::OF_TextWithCRLF);
+        Filename, EC,
+        llvm::sys::fs::OF_TextWithCRLF | llvm::sys::fs::OF_Append);
     if (EC) {
       D.Diag(clang::diag::err_drv_compilationdatabase) << Filename
                                                        << EC.message();
@@ -2432,6 +2433,7 @@
     CDB << ", \"" << escape(Buf) << "\"";
   }
   CDB << ", \"" << escape(Input.getFilename()) << "\"";
+  CDB << ", \"-o\", \"" << escape(Output.getFilename()) << "\"";
   for (auto &A: Args) {
     auto &O = A->getOption();
     // Skip language selection, which is positional.
@@ -2445,6 +2447,9 @@
     // Skip inputs.
     if (O.getKind() == Option::InputClass)
       continue;
+    // Skip output.
+    if (O.getID() == options::OPT_o)
+      continue;
     // All other arguments are quoted and appended.
     ArgStringList ASL;
     A->render(Args, ASL);
diff --git a/clang/test/Driver/compilation_database.c b/clang/test/Driver/compilation_database.c
--- a/clang/test/Driver/compilation_database.c
+++ b/clang/test/Driver/compilation_database.c
@@ -2,8 +2,8 @@
 // RUN: %clang -no-canonical-prefixes -fintegrated-as -MD -MP --sysroot=somewhere -c -x c %s -xc++ %s -Wall -MJ - 2>&1 | FileCheck %s
 // RUN: not %clang -no-canonical-prefixes -c -x c %s -MJ %s/non-existant 2>&1 | FileCheck --check-prefix=ERROR %s
 
-// CHECK: { "directory": "{{[^"]*}}workdir",  "file": "[[SRC:[^"]+[/|\\]compilation_database.c]]", "output": "compilation_database.o", "arguments": ["{{[^"]*}}clang{{[^"]*}}", "-xc", "[[SRC]]", "-no-canonical-prefixes", "-fintegrated-as", "--sysroot=somewhere", "-c", "-Wall",{{.*}} "--target={{[^"]+}}"]},
-// CHECK: { "directory": "{{.*}}",  "file": "[[SRC:[^"]+[/|\\]compilation_database.c]]", "output": "compilation_database.o", "arguments": ["{{[^"]*}}clang{{[^"]*}}", "-xc++", "[[SRC]]", "-no-canonical-prefixes", "-fintegrated-as", "--sysroot=somewhere", "-c", "-Wall",{{.*}} "--target={{[^"]+}}"]},
+// CHECK: { "directory": "{{[^"]*}}workdir",  "file": "[[SRC:[^"]+[/|\\]compilation_database.c]]", "output": "compilation_database.o", "arguments": ["{{[^"]*}}clang{{[^"]*}}", "-xc", "[[SRC]]", "-o", "compilation_database.o", "-no-canonical-prefixes", "-fintegrated-as", "--sysroot=somewhere", "-c", "-Wall",{{.*}} "--target={{[^"]+}}"]},
+// CHECK: { "directory": "{{.*}}",  "file": "[[SRC:[^"]+[/|\\]compilation_database.c]]", "output": "compilation_database.o", "arguments": ["{{[^"]*}}clang{{[^"]*}}", "-xc++", "[[SRC]]", "-o", "compilation_database.o", "-no-canonical-prefixes", "-fintegrated-as", "--sysroot=somewhere", "-c", "-Wall",{{.*}} "--target={{[^"]+}}"]},
 // ERROR: error: compilation database '{{.*}}/non-existant' could not be opened:
 
 int main(void) {
diff --git a/clang/test/Driver/compilation_database_multiarch.c b/clang/test/Driver/compilation_database_multiarch.c
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/compilation_database_multiarch.c
@@ -0,0 +1,6 @@
+// RUN: rm -rf %t && mkdir -p %t
+// RUN: %clang -fdriver-only -o %t/out %s -mtargetos=macos12 -arch arm64 -arch x86_64 -MJ %t/compilation_database.json
+// RUN: FileCheck --input-file=%t/compilation_database.json %s
+
+// CHECK:      { "directory": "{{.*}}", "file": "{{.*}}", "output": "[[OUTPUT_X86_64:.*]]", "arguments": [{{.*}}, "-o", "[[OUTPUT_X86_64]]", {{.*}} "--target=x86_64-apple-macosx12.0.0"]},
+// CHECK-NEXT: { "directory": "{{.*}}", "file": "{{.*}}", "output": "[[OUTPUT_ARM64:.*]]", "arguments": [{{.*}}, "-o", "[[OUTPUT_ARM64]]", {{.*}} "--target=arm64-apple-macosx12.0.0"]},