diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -2382,7 +2382,8 @@
   if (!CompilationDatabase) {
     std::error_code EC;
     auto File = std::make_unique<llvm::raw_fd_ostream>(
-        Filename, EC, llvm::sys::fs::OF_TextWithCRLF);
+        Filename, EC,
+        llvm::sys::fs::OF_TextWithCRLF | llvm::sys::fs::OF_Append);
     if (EC) {
       D.Diag(clang::diag::err_drv_compilationdatabase) << Filename
                                                        << EC.message();
diff --git a/clang/test/Driver/compilation_database_multiarch.c b/clang/test/Driver/compilation_database_multiarch.c
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/compilation_database_multiarch.c
@@ -0,0 +1,6 @@
+// RUN: rm -rf %t && mkdir -p %t
+// RUN: %clang -c %s -o %t/out -target x86_64-apple-macos -arch arm64 -arch x86_64 -MJ %t/compilation_database.json
+// RUN: FileCheck --input-file=%t/compilation_database.json %s
+
+// CHECK:      { "directory": "{{.*}}", "file": "{{.*}}", "output": "{{.*}}", "arguments": [{{.*}} "--target=arm64-apple-macosx12.0.0"]},
+// CHECK-NEXT: { "directory": "{{.*}}", "file": "{{.*}}", "output": "{{.*}}", "arguments": [{{.*}} "--target=x86_64-apple-macosx12.0.0"]},