diff --git a/clang/lib/CodeGen/CGOpenMPRuntime.cpp b/clang/lib/CodeGen/CGOpenMPRuntime.cpp
--- a/clang/lib/CodeGen/CGOpenMPRuntime.cpp
+++ b/clang/lib/CodeGen/CGOpenMPRuntime.cpp
@@ -35,6 +35,7 @@
 #include "llvm/IR/Constants.h"
 #include "llvm/IR/DerivedTypes.h"
 #include "llvm/IR/GlobalValue.h"
+#include "llvm/IR/InstrTypes.h"
 #include "llvm/IR/Value.h"
 #include "llvm/Support/AtomicOrdering.h"
 #include "llvm/Support/Format.h"
@@ -1940,8 +1941,12 @@
       CtorCGF.StartFunction(GlobalDecl(), CGM.getContext().VoidTy, Fn, FI,
                             FunctionArgList(), Loc, Loc);
       auto AL = ApplyDebugLocation::CreateArtificial(CtorCGF);
+      auto *AddrInAS0 = llvm::ConstantExpr::getAddrSpaceCast(
+          Addr, llvm::PointerType::getWithSamePointeeType(
+                    cast<llvm::PointerType>(Addr->getType()), 0));
       CtorCGF.EmitAnyExprToMem(
-          Init, Address::deprecated(Addr, CGM.getContext().getDeclAlign(VD)),
+          Init,
+          Address::deprecated(AddrInAS0, CGM.getContext().getDeclAlign(VD)),
           Init->getType().getQualifiers(),
           /*IsInitializer=*/true);
       CtorCGF.FinishFunction();
@@ -1980,9 +1985,12 @@
       // Create a scope with an artificial location for the body of this
       // function.
       auto AL = ApplyDebugLocation::CreateArtificial(DtorCGF);
+      auto *AddrInAS0 = llvm::ConstantExpr::getAddrSpaceCast(
+          Addr, llvm::PointerType::getWithSamePointeeType(
+                    cast<llvm::PointerType>(Addr->getType()), 0));
       DtorCGF.emitDestroy(
-          Address::deprecated(Addr, CGM.getContext().getDeclAlign(VD)), ASTTy,
-          DtorCGF.getDestroyer(ASTTy.isDestructedType()),
+          Address::deprecated(AddrInAS0, CGM.getContext().getDeclAlign(VD)),
+          ASTTy, DtorCGF.getDestroyer(ASTTy.isDestructedType()),
           DtorCGF.needsEHCleanup(ASTTy.isDestructedType()));
       DtorCGF.FinishFunction();
       Dtor = Fn;
diff --git a/clang/test/OpenMP/amdgcn_target_global_constructor.cpp b/clang/test/OpenMP/amdgcn_target_global_constructor.cpp
new file mode 100644
--- /dev/null
+++ b/clang/test/OpenMP/amdgcn_target_global_constructor.cpp
@@ -0,0 +1,21 @@
+// REQUIRES: amdgpu-registered-target
+
+// RUN: %clang_cc1 -fopenmp -x c++ -std=c++11 -triple x86_64-unknown-unknown -fopenmp-targets=amdgcn-amd-amdhsa -emit-llvm-bc %s -o %t-ppc-host.bc
+// RUN: %clang_cc1 -fopenmp -x c++ -std=c++11 -triple amdgcn-amd-amdhsa -fopenmp-targets=amdgcn-amd-amdhsa -emit-llvm %s -fopenmp-is-device -fopenmp-host-ir-file-path %t-ppc-host.bc -o - | FileCheck %s
+// expected-no-diagnostics
+#ifndef HEADER
+#define HEADER
+
+void foo(void);
+
+struct S {
+  int a;
+  S() : a(1) {}
+  ~S() { foo(); }
+};
+
+#pragma omp declare target
+S A;
+#pragma omp end declare target
+
+#endif