diff --git a/llvm/lib/Transforms/Vectorize/VectorCombine.cpp b/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
--- a/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
+++ b/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
@@ -190,6 +190,10 @@
     if (Offset.isNegative())
       return false;
 
+    // We can't bitcast this pointer due to differing address spaces.
+    if (AS != SrcPtr->getType()->getPointerAddressSpace())
+      return false;
+
     // The offset must be a multiple of the scalar element to shuffle cleanly
     // in the element's size.
     uint64_t ScalarSizeInBytes = ScalarSize / 8;
diff --git a/llvm/test/Transforms/VectorCombine/X86/load-inselt-addrspace.ll b/llvm/test/Transforms/VectorCombine/X86/load-inselt-addrspace.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/VectorCombine/X86/load-inselt-addrspace.ll
@@ -0,0 +1,20 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s -passes=vector-combine -S -mtriple=x86_64-- -mattr=sse2 | FileCheck %s
+; RUN: opt < %s -passes=vector-combine -S -mtriple=x86_64-- -mattr=avx2 | FileCheck %s
+
+define <4 x i32> @unsafe_load_i32_insert_v4i32_addrspace(i32* align 16 dereferenceable(16) %v3) {
+; CHECK-LABEL: @unsafe_load_i32_insert_v4i32_addrspace(
+; CHECK-NEXT:    [[T0:%.*]] = getelementptr inbounds i32, i32* [[V3:%.*]], i32 1
+; CHECK-NEXT:    [[T1:%.*]] = addrspacecast i32* [[T0]] to i32 addrspace(42)*
+; CHECK-NEXT:    [[T2:%.*]] = getelementptr inbounds i32, i32 addrspace(42)* [[T1]], i64 1
+; CHECK-NEXT:    [[VAL:%.*]] = load i32, i32 addrspace(42)* [[T2]], align 4
+; CHECK-NEXT:    [[INSELT:%.*]] = insertelement <4 x i32> poison, i32 [[VAL]], i32 0
+; CHECK-NEXT:    ret <4 x i32> [[INSELT]]
+;
+  %t0 = getelementptr inbounds i32, i32* %v3, i32 1
+  %t1 = addrspacecast i32* %t0 to i32 addrspace(42)*
+  %t2 = getelementptr inbounds i32, i32 addrspace(42)* %t1, i64 1
+  %val = load i32, i32 addrspace(42)* %t2, align 4
+  %inselt = insertelement <4 x i32> poison, i32 %val, i32 0
+  ret <4 x i32> %inselt
+}