diff --git a/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.h b/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.h
--- a/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.h
+++ b/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.h
@@ -37,6 +37,7 @@
   /// @{
 
   unsigned getInliningThresholdMultiplier() { return 3; }
+  unsigned adjustInliningThreshold(const CallBase *CB) const;
 
   InstructionCost getIntImmCost(const APInt &Imm, Type *Ty,
                                 TTI::TargetCostKind CostKind);
diff --git a/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.cpp b/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.cpp
--- a/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.cpp
+++ b/llvm/lib/Target/SystemZ/SystemZTargetTransformInfo.cpp
@@ -30,6 +30,42 @@
 //
 //===----------------------------------------------------------------------===//
 
+static bool isUsedAsMemCpySource(const Value *V, bool &OtherUse) {
+  bool UsedAsMemCpySource = false;
+  for (const User *U : V->users())
+    if (const Instruction *User = dyn_cast<Instruction>(U)) {
+      if (isa<BitCastInst>(User) || isa<GetElementPtrInst>(User)) {
+        UsedAsMemCpySource |= isUsedAsMemCpySource(User, OtherUse);
+        continue;
+      }
+      if (const MemCpyInst *Memcpy = dyn_cast<MemCpyInst>(User)) {
+        if (Memcpy->getOperand(1) == V && !Memcpy->isVolatile()) {
+          UsedAsMemCpySource = true;
+          continue;
+        }
+      }
+      OtherUse = true;
+    }
+  return UsedAsMemCpySource;
+}
+
+unsigned SystemZTTIImpl::adjustInliningThreshold(const CallBase *CB) const {
+  unsigned Bonus = 0;
+
+  // Increase the threshold if an incoming argument is used only as a memcpy
+  // source.
+  if (Function *Callee = CB->getCalledFunction())
+    for (Argument &Arg : Callee->args()) {
+      bool OtherUse = false;
+      if (isUsedAsMemCpySource(&Arg, OtherUse) && !OtherUse)
+        Bonus += 150;
+    }
+
+  LLVM_DEBUG(if (Bonus)
+               dbgs() << "++ SZTTI Adding inlining bonus: " << Bonus << "\n";);
+  return Bonus;
+}
+
 InstructionCost SystemZTTIImpl::getIntImmCost(const APInt &Imm, Type *Ty,
                                               TTI::TargetCostKind CostKind) {
   assert(Ty->isIntegerTy());
diff --git a/llvm/test/CodeGen/SystemZ/inline-thresh-adjust.ll b/llvm/test/CodeGen/SystemZ/inline-thresh-adjust.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/SystemZ/inline-thresh-adjust.ll
@@ -0,0 +1,32 @@
+; RUN: opt < %s -mtriple=systemz-unknown -mcpu=z15 -inline -disable-output \
+; RUN:   -debug-only=inline,systemztti 2>&1 | FileCheck %s
+; REQUIRES: asserts
+;
+; Check that the inlining threshold is incremented for a function using an
+; argument only as a memcpy source.
+
+; CHECK: Inlining calls in: root_function
+; CHECK:     Inlining {{.*}} Call:   call void @leaf_function_A(i8* %Dst)
+; CHECK:     ++ SZTTI Adding inlining bonus: 150
+; CHECK:     Inlining {{.*}} Call:   call void @leaf_function_B(i8* %Dst, i8* %Src)
+
+define void @leaf_function_A(i8* %Dst)  {
+entry:
+  call void @llvm.memcpy.p0i8.p0i8.i64(i8* %Dst, i8* undef, i64 16, i1 false)
+  ret void
+}
+
+define void @leaf_function_B(i8* %Dst, i8* %Src)  {
+entry:
+  call void @llvm.memcpy.p0i8.p0i8.i64(i8* %Dst, i8* %Src, i64 16, i1 false)
+  ret void
+}
+
+define void @root_function(i8* %Dst, i8* %Src) {
+entry:
+  call void @leaf_function_A(i8* %Dst)
+  call void @leaf_function_B(i8* %Dst, i8* %Src)
+  ret void
+}
+
+declare void @llvm.memcpy.p0i8.p0i8.i64(i8* noalias nocapture writeonly, i8* noalias nocapture readonly, i64, i1 immarg)