Index: clang/include/clang/Driver/ToolChain.h
===================================================================
--- clang/include/clang/Driver/ToolChain.h
+++ clang/include/clang/Driver/ToolChain.h
@@ -513,6 +513,9 @@
   /// compile unit information.
   virtual bool UseDwarfDebugFlags() const { return false; }
 
+  /// Add an additional -fdebug-prefix-map entry.
+  virtual std::string GetGlobalDebugPathRemapping() const { return {}; }
+  
   // Return the DWARF version to emit, in the absence of arguments
   // to the contrary.
   virtual unsigned GetDefaultDwarfVersion() const { return 5; }
Index: clang/lib/Driver/ToolChains/Clang.cpp
===================================================================
--- clang/lib/Driver/ToolChains/Clang.cpp
+++ clang/lib/Driver/ToolChains/Clang.cpp
@@ -668,7 +668,8 @@
 }
 
 /// Add a CC1 and CC1AS option to specify the debug file path prefix map.
-static void addDebugPrefixMapArg(const Driver &D, const ArgList &Args, ArgStringList &CmdArgs) {
+static void addDebugPrefixMapArg(const Driver &D, const ToolChain &TC,
+                                 const ArgList &Args, ArgStringList &CmdArgs) {
   for (const Arg *A : Args.filtered(options::OPT_ffile_prefix_map_EQ,
                                     options::OPT_fdebug_prefix_map_EQ)) {
     StringRef Map = A->getValue();
@@ -679,6 +680,15 @@
       CmdArgs.push_back(Args.MakeArgString("-fdebug-prefix-map=" + Map));
     A->claim();
   }
+  std::string GlobalRemapEntry = TC.GetGlobalDebugPathRemapping();
+  if (GlobalRemapEntry.empty())
+    return;
+  if (!StringRef(GlobalRemapEntry).contains('='))
+    D.Diag(diag::err_drv_invalid_argument_to_option)
+        << GlobalRemapEntry << "environment";
+
+  CmdArgs.push_back(
+        Args.MakeArgString("-fdebug-prefix-map=" + GlobalRemapEntry));
 }
 
 /// Add a CC1 and CC1AS option to specify the macro file path prefix map.
@@ -5717,7 +5727,7 @@
   const char *DebugCompilationDir =
       addDebugCompDirArg(Args, CmdArgs, D.getVFS());
 
-  addDebugPrefixMapArg(D, Args, CmdArgs);
+  addDebugPrefixMapArg(D, TC, Args, CmdArgs);
 
   if (Arg *A = Args.getLastArg(options::OPT_ftemplate_depth_,
                                options::OPT_ftemplate_depth_EQ)) {
@@ -7785,7 +7795,8 @@
     DebugInfoKind = (WantDebug ? codegenoptions::DebugInfoConstructor
                                : codegenoptions::NoDebugInfo);
 
-    addDebugPrefixMapArg(getToolChain().getDriver(), Args, CmdArgs);
+    addDebugPrefixMapArg(getToolChain().getDriver(), getToolChain(), Args,
+                         CmdArgs);
 
     // Set the AT_producer to the clang version when using the integrated
     // assembler on assembly source files.
Index: clang/lib/Driver/ToolChains/Darwin.h
===================================================================
--- clang/lib/Driver/ToolChains/Darwin.h
+++ clang/lib/Driver/ToolChains/Darwin.h
@@ -267,6 +267,7 @@
   bool SupportsProfiling() const override;
 
   bool UseDwarfDebugFlags() const override;
+  std::string GetGlobalDebugPathRemapping() const override;
 
   llvm::ExceptionHandling
   GetExceptionModel(const llvm::opt::ArgList &Args) const override {
Index: clang/lib/Driver/ToolChains/Darwin.cpp
===================================================================
--- clang/lib/Driver/ToolChains/Darwin.cpp
+++ clang/lib/Driver/ToolChains/Darwin.cpp
@@ -2772,6 +2772,12 @@
   return false;
 }
 
+std::string MachO::GetGlobalDebugPathRemapping() const {
+  if (const char *S = ::getenv("RC_DEBUG_PREFIX_MAP"))
+    return S;
+  return {};
+}
+
 llvm::ExceptionHandling Darwin::GetExceptionModel(const ArgList &Args) const {
   // Darwin uses SjLj exceptions on ARM.
   if (getTriple().getArch() != llvm::Triple::arm &&
Index: clang/test/Driver/darwin-debug-prefix-map.c
===================================================================
--- /dev/null
+++ clang/test/Driver/darwin-debug-prefix-map.c
@@ -0,0 +1,6 @@
+// RUN: env RC_DEBUG_PREFIX_MAP=old=new \
+// RUN:  %clang -target arm64-apple-darwin -### -c -g %s 2>&1 | FileCheck %s
+// RUN: env RC_DEBUG_PREFIX_MAP=illegal \
+// RUN:  %clang -target arm64-apple-darwin -### -c -g %s 2>&1 | FileCheck %s --check-prefix=ERR
+// CHECK: "-fdebug-prefix-map=old=new" 
+// ERR: invalid argument 'illegal'
Index: clang/test/Driver/darwin-debug-prefix-map.s
===================================================================
--- /dev/null
+++ clang/test/Driver/darwin-debug-prefix-map.s
@@ -0,0 +1,6 @@
+// RUN: env RC_DEBUG_PREFIX_MAP=old=new \
+// RUN:  %clang -target arm64-apple-darwin -### -c -g %s 2>&1 | FileCheck %s
+// RUN: env RC_DEBUG_PREFIX_MAP=illegal \
+// RUN:  %clang -target arm64-apple-darwin -### -c -g %s 2>&1 | FileCheck %s --check-prefix=ERR
+// CHECK: "-fdebug-prefix-map=old=new" 
+// ERR: invalid argument 'illegal'