diff --git a/llvm/lib/Transforms/Utils/SimplifyCFG.cpp b/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
--- a/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
+++ b/llvm/lib/Transforms/Utils/SimplifyCFG.cpp
@@ -6652,6 +6652,15 @@
 /// merged.  In some cases, this could result in removal of the PHI entirely.
 static bool TryToMergeLandingPad(LandingPadInst *LPad, BranchInst *BI,
                                  BasicBlock *BB, DomTreeUpdater *DTU) {
+
+  // Invokes with deopt bundles must have unique landingpads
+  // (See RewriteStatepointsForGC.cpp). Prohibit landingpad merging
+  // for such invokes.
+  BasicBlock *Pred = *pred_begin(BB);
+  if (auto *Invoke = dyn_cast<InvokeInst>(Pred->getTerminator()))
+    if (Invoke->getOperandBundle(LLVMContext::OB_deopt))
+      return false;
+
   auto Succ = BB->getUniqueSuccessor();
   assert(Succ);
   // If there's a phi in the successor block, we'd likely have to introduce
diff --git a/llvm/test/Transforms/SimplifyCFG/duplicate-landingpad.ll b/llvm/test/Transforms/SimplifyCFG/duplicate-landingpad.ll
--- a/llvm/test/Transforms/SimplifyCFG/duplicate-landingpad.ll
+++ b/llvm/test/Transforms/SimplifyCFG/duplicate-landingpad.ll
@@ -147,3 +147,52 @@
   call void @fn()
   ret void
 }
+
+; Should not trigger when invokes have deopt bundles
+; CHECK-LABEL: @neg3(
+; CHECK-NEXT:  entry:
+; CHECK-NEXT:    invoke void @fn()
+; CHECK-NEXT:    to label [[INVOKE2:%.*]] unwind label [[LPAD1:%.*]]
+; CHECK:       invoke2:
+; CHECK-NEXT:    invoke void @fn()
+; CHECK-NEXT:    to label [[COMMON_RET:%.*]] unwind label [[LPAD2:%.*]]
+; CHECK:       common.ret:
+; CHECK-NEXT:    ret void
+; CHECK:       lpad1:
+; CHECK-NEXT:    [[EXN:%.*]] = landingpad { i8*, i32 }
+; CHECK-NEXT:    cleanup
+; CHECK-NEXT:    br label [[SHARED_RESUME:%.*]]
+; CHECK:       lpad2:
+; CHECK-NEXT:    [[EXN2:%.*]] = landingpad { i8*, i32 }
+; CHECK-NEXT:    cleanup
+; CHECK-NEXT:    br label [[SHARED_RESUME]]
+; CHECK:       shared_resume:
+; CHECK-NEXT:    call void @fn()
+; CHECK-NEXT:    br label [[COMMON_RET]]
+;
+define void @neg3() gc "statepoint-example" personality i32 (...)* @__gxx_personality_v0 {
+entry:
+  invoke void @fn() [ "deopt"() ]
+  to label %invoke2 unwind label %lpad1
+
+invoke2:
+  invoke void @fn() [ "deopt"() ]
+  to label %invoke.cont unwind label %lpad2
+
+invoke.cont:
+  ret void
+
+lpad1:
+  %exn = landingpad {i8*, i32}
+  cleanup
+  br label %shared_resume
+
+lpad2:
+  %exn2 = landingpad {i8*, i32}
+  cleanup
+  br label %shared_resume
+
+shared_resume:
+  call void @fn()
+  ret void
+}