diff --git a/clang/lib/Format/QualifierAlignmentFixer.cpp b/clang/lib/Format/QualifierAlignmentFixer.cpp
--- a/clang/lib/Format/QualifierAlignmentFixer.cpp
+++ b/clang/lib/Format/QualifierAlignmentFixer.cpp
@@ -390,6 +390,10 @@
 
   for (AnnotatedLine *Line : AnnotatedLines) {
     FormatToken *First = Line->First;
+    assert(First);
+    if (First->Finalized)
+      continue;
+
     const auto *Last = Line->Last;
 
     for (const auto *Tok = First; Tok && Tok != Last && Tok->Next;
diff --git a/clang/unittests/Format/QualifierFixerTest.cpp b/clang/unittests/Format/QualifierFixerTest.cpp
--- a/clang/unittests/Format/QualifierFixerTest.cpp
+++ b/clang/unittests/Format/QualifierFixerTest.cpp
@@ -858,5 +858,27 @@
                Style);
 }
 
+TEST_F(QualifierFixerTest, DisableRegions) {
+  FormatStyle Style = getLLVMStyle();
+  Style.QualifierAlignment = FormatStyle::QAS_Custom;
+  Style.QualifierOrder = {"inline", "static", "const", "type"};
+
+  ReplacementCount = 0;
+  verifyFormat("// clang-format off\n"
+               "int const inline static a = 0;\n"
+               "// clang-format on\n",
+               Style);
+  EXPECT_EQ(ReplacementCount, 0);
+  verifyFormat("// clang-format off\n"
+               "int const inline static a = 0;\n"
+               "// clang-format on\n"
+               "inline static const int a = 0;\n",
+               "// clang-format off\n"
+               "int const inline static a = 0;\n"
+               "// clang-format on\n"
+               "int const inline static a = 0;\n",
+               Style);
+}
+
 } // namespace format
 } // namespace clang