diff --git a/clang/lib/Basic/Targets/WebAssembly.cpp b/clang/lib/Basic/Targets/WebAssembly.cpp
--- a/clang/lib/Basic/Targets/WebAssembly.cpp
+++ b/clang/lib/Basic/Targets/WebAssembly.cpp
@@ -260,6 +260,7 @@
   if (!HasAtomics) {
     Opts.POSIXThreads = false;
     Opts.setThreadModel(LangOptions::ThreadModelKind::Single);
+    Opts.ThreadsafeStatics = false;
   }
 }
 
diff --git a/clang/test/CodeGenCXX/static-init-wasm.cpp b/clang/test/CodeGenCXX/static-init-wasm.cpp
--- a/clang/test/CodeGenCXX/static-init-wasm.cpp
+++ b/clang/test/CodeGenCXX/static-init-wasm.cpp
@@ -1,6 +1,6 @@
-// RUN: %clang_cc1 -emit-llvm -triple=wasm32-unknown-unknown -o - %s \
+// RUN: %clang_cc1 -emit-llvm -triple=wasm32-unknown-unknown -target-feature +atomics -o - %s \
 // RUN:   | FileCheck %s -check-prefix=WEBASSEMBLY32
-// RUN: %clang_cc1 -emit-llvm -triple=wasm64-unknown-unknown -o - %s \
+// RUN: %clang_cc1 -emit-llvm -triple=wasm64-unknown-unknown -target-feature +atomics -o - %s \
 // RUN:   | FileCheck %s -check-prefix=WEBASSEMBLY64
 
 // Test that we don't create common blocks.
@@ -52,3 +52,17 @@
 // WEBASSEMBLY64: call noundef %struct.A* @_ZN1AC1Ev(%struct.A* {{[^,]*}} @theA)
 // WEBASSEMBLY64: define internal void @_GLOBAL__sub_I_static_init_wasm.cpp() #3 {
 // WEBASSEMBLY64: call void @__cxx_global_var_init()
+
+// RUN: %clang_cc1 -emit-llvm -triple=wasm32-unknown-unknown -o - %s \
+// RUN:   | FileCheck %s -check-prefix=NOATOMICS
+// RUN: %clang_cc1 -emit-llvm -triple=wasm64-unknown-unknown -o - %s \
+// RUN:   | FileCheck %s -check-prefix=NOATOMICS
+
+// NOATOMICS-LABEL: @_Z1gv()
+// NOATOMICS:       %[[R0:.+]] = load i8, i8* @_ZGVZ1gvE1a, align 1
+// NOATOMICS-NEXT:  %guard.uninitialized = icmp eq i8 %[[R0]], 0
+// NOATOMICS-NEXT:  br i1 %guard.uninitialized, label %[[CHECK:.+]], label %[[END:.+]],
+// NOATOMICS:       [[CHECK]]:
+// NOATOMICS-NOT:   __cxa_guard_acquire
+// NOATOMICS:       [[END]]:
+// NOATOMICS-NEXT:  ret void