diff --git a/clang/lib/CodeGen/CGOpenMPRuntimeGPU.cpp b/clang/lib/CodeGen/CGOpenMPRuntimeGPU.cpp
--- a/clang/lib/CodeGen/CGOpenMPRuntimeGPU.cpp
+++ b/clang/lib/CodeGen/CGOpenMPRuntimeGPU.cpp
@@ -1198,7 +1198,8 @@
     llvm_unreachable("OpenMP can only handle device code.");
 
   llvm::OpenMPIRBuilder &OMPBuilder = getOMPBuilder();
-  if (CGM.getLangOpts().OpenMPTargetNewRuntime) {
+  if (CGM.getLangOpts().OpenMPTargetNewRuntime &&
+      !CGM.getLangOpts().OMPHostIRFile.empty()) {
     OMPBuilder.createGlobalFlag(CGM.getLangOpts().OpenMPTargetDebug,
                                 "__omp_rtl_debug_kind");
     OMPBuilder.createGlobalFlag(CGM.getLangOpts().OpenMPTeamSubscription,
diff --git a/clang/test/OpenMP/target_globals_codegen.cpp b/clang/test/OpenMP/target_globals_codegen.cpp
--- a/clang/test/OpenMP/target_globals_codegen.cpp
+++ b/clang/test/OpenMP/target_globals_codegen.cpp
@@ -6,6 +6,7 @@
 // RUN: %clang_cc1 -verify -fopenmp -x c++ -triple nvptx64-unknown-unknown -fopenmp-targets=nvptx64-nvidia-cuda -emit-llvm %s -fopenmp-target-new-runtime -fopenmp-is-device -fopenmp-host-ir-file-path %t-ppc-host.bc -o - | FileCheck %s --check-prefix=CHECK-DEFAULT
 // RUN: %clang_cc1 -verify -fopenmp -x c++ -triple nvptx64-unknown-unknown -fopenmp-targets=nvptx64-nvidia-cuda -emit-llvm %s -fopenmp-target-new-runtime -fopenmp-assume-threads-oversubscription -fopenmp-is-device -fopenmp-host-ir-file-path %t-ppc-host.bc -o - | FileCheck %s --check-prefix=CHECK-THREADS
 // RUN: %clang_cc1 -verify -fopenmp -x c++ -triple nvptx64-unknown-unknown -fopenmp-targets=nvptx64-nvidia-cuda -emit-llvm %s -fopenmp-target-new-runtime -fopenmp-assume-teams-oversubscription -fopenmp-is-device -fopenmp-host-ir-file-path %t-ppc-host.bc -o - | FileCheck %s --check-prefix=CHECK-TEAMS
+// RUN: %clang_cc1 -verify -fopenmp -x c++ -triple nvptx64-unknown-unknown -fopenmp-targets=nvptx64-nvidia-cuda -emit-llvm %s -fopenmp-target-new-runtime -fopenmp-assume-teams-oversubscription -fopenmp-is-device -o - | FileCheck %s --check-prefix=CHECK-RUNTIME
 // expected-no-diagnostics
 
 #ifndef HEADER
@@ -32,6 +33,10 @@
 // CHECK-TEAMS: @__omp_rtl_assume_teams_oversubscription = weak_odr hidden constant i32 1
 // CHECK-TEAMS: @__omp_rtl_assume_threads_oversubscription = weak_odr hidden constant i32 0
 //.
+// CHECK-RUNTIME-NOT: @__omp_rtl_debug_kind = weak_odr hidden constant i32 0
+// CHECK-RUNTIME-NOT: @__omp_rtl_assume_teams_oversubscription = weak_odr hidden constant i32 1
+// CHECK-RUNTIME-NOT: @__omp_rtl_assume_threads_oversubscription = weak_odr hidden constant i32 0
+//.
 void foo() {
 #pragma omp target
   { }