diff --git a/llvm/lib/Target/AMDGPU/SIInstructions.td b/llvm/lib/Target/AMDGPU/SIInstructions.td
--- a/llvm/lib/Target/AMDGPU/SIInstructions.td
+++ b/llvm/lib/Target/AMDGPU/SIInstructions.td
@@ -368,7 +368,13 @@
 // SI pseudo instructions. These are used by the CFG structurizer pass
 // and should be lowered to ISA instructions prior to codegen.
 
-let isTerminator = 1 in {
+// As we have enhanced control flow intrinsics to work under unstructured CFG,
+// duplicating such intrinsics can be actually treated as legal. On the contrary,
+// by making them non-duplicable, we are observing better code generation result.
+// So we choose to mark them non-duplicable in hope of getting better code
+// generation as well as simplied CFG during Machine IR optimization stage.
+
+let isTerminator = 1, isNotDuplicable = 1 in {
 
 let OtherPredicates = [EnableLateCFGStructurize] in {
  def SI_NON_UNIFORM_BRCOND_PSEUDO : CFPseudoInstSI <
@@ -418,6 +424,7 @@
   let isAsCheapAsAMove = 1;
   let isReMaterializable = 1;
   let hasSideEffects = 1;
+  let isNotDuplicable = 1;
   let mayLoad = 1; // FIXME: Should not need memory flags
   let mayStore = 1;
 }
@@ -425,6 +432,7 @@
 def SI_IF_BREAK : CFPseudoInstSI <
   (outs SReg_1:$dst), (ins SReg_1:$vcc, SReg_1:$src), []> {
   let Size = 4;
+  let isNotDuplicable = 1;
   let isAsCheapAsAMove = 1;
   let isReMaterializable = 1;
 }
diff --git a/llvm/test/CodeGen/AMDGPU/stop-tail-duplicate-cfg-intrinsic.mir b/llvm/test/CodeGen/AMDGPU/stop-tail-duplicate-cfg-intrinsic.mir
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AMDGPU/stop-tail-duplicate-cfg-intrinsic.mir
@@ -0,0 +1,73 @@
+# NOTE: Assertions have been autogenerated by utils/update_mir_test_checks.py
+# RUN: llc -mtriple=amdgcn-amd-amdhsa -run-pass=early-tailduplication -verify-machineinstrs -o - %s | FileCheck %s
+
+---
+name:            stop_duplicate_cfg_intrinsic
+tracksRegLiveness: true
+body: |
+  ; CHECK-LABEL: name: stop_duplicate_cfg_intrinsic
+  ; CHECK: bb.0:
+  ; CHECK-NEXT:   successors: %bb.1(0x80000000)
+  ; CHECK-NEXT:   liveins: $vgpr0
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT:   [[COPY:%[0-9]+]]:vgpr_32 = COPY $vgpr0
+  ; CHECK-NEXT:   [[DEF:%[0-9]+]]:sreg_64 = IMPLICIT_DEF
+  ; CHECK-NEXT:   [[S_MOV_B32_:%[0-9]+]]:sreg_32 = S_MOV_B32 0
+  ; CHECK-NEXT:   [[COPY1:%[0-9]+]]:vgpr_32 = COPY [[S_MOV_B32_]]
+  ; CHECK-NEXT:   [[V_CMP_EQ_U32_e64_:%[0-9]+]]:sreg_64_xexec = V_CMP_EQ_U32_e64 [[COPY]], [[COPY1]], implicit $exec
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT: bb.1:
+  ; CHECK-NEXT:   successors: %bb.2(0x40000000), %bb.3(0x40000000)
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT:   [[PHI:%[0-9]+]]:vgpr_32 = PHI [[S_MOV_B32_]], %bb.0, %6, %bb.3
+  ; CHECK-NEXT:   [[SI_IF:%[0-9]+]]:sreg_64_xexec = SI_IF [[V_CMP_EQ_U32_e64_]], %bb.2, implicit-def $exec, implicit-def $scc, implicit $exec
+  ; CHECK-NEXT:   S_BRANCH %bb.3
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT: bb.2:
+  ; CHECK-NEXT:   successors: %bb.3(0x80000000)
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT:   SI_END_CF [[SI_IF]], implicit-def $exec, implicit-def $scc, implicit $exec
+  ; CHECK-NEXT:   [[S_MOV_B32_1:%[0-9]+]]:sreg_32 = S_MOV_B32 1
+  ; CHECK-NEXT:   [[COPY2:%[0-9]+]]:vgpr_32 = COPY [[S_MOV_B32_1]]
+  ; CHECK-NEXT:   [[V_ADD_CO_U32_e64_:%[0-9]+]]:vgpr_32, dead [[V_ADD_CO_U32_e64_1:%[0-9]+]]:sreg_64_xexec = V_ADD_CO_U32_e64 [[PHI]], [[COPY2]], 0, implicit $exec
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT: bb.3:
+  ; CHECK-NEXT:   successors: %bb.1(0x80000000)
+  ; CHECK-NEXT: {{  $}}
+  ; CHECK-NEXT:   [[PHI1:%[0-9]+]]:vgpr_32 = PHI [[V_ADD_CO_U32_e64_]], %bb.2, [[PHI]], %bb.1
+  ; CHECK-NEXT:   [[S_MOV_B32_2:%[0-9]+]]:sreg_32 = S_MOV_B32 4294967295
+  ; CHECK-NEXT:   [[S_MOV_B32_3:%[0-9]+]]:sreg_32 = S_MOV_B32 61440
+  ; CHECK-NEXT:   [[REG_SEQUENCE:%[0-9]+]]:sreg_64 = REG_SEQUENCE [[S_MOV_B32_2]], %subreg.sub0, [[S_MOV_B32_3]], %subreg.sub1
+  ; CHECK-NEXT:   [[REG_SEQUENCE1:%[0-9]+]]:sgpr_128 = REG_SEQUENCE [[DEF]], %subreg.sub0_sub1, [[REG_SEQUENCE]], %subreg.sub2_sub3
+  ; CHECK-NEXT:   BUFFER_STORE_DWORD_OFFSET [[PHI1]], [[REG_SEQUENCE1]], 0, 0, 0, 0, implicit $exec
+  ; CHECK-NEXT:   S_BRANCH %bb.1
+  bb.1:
+    liveins: $vgpr0
+
+    %0:vgpr_32 = COPY $vgpr0
+    %12:sreg_64 = IMPLICIT_DEF
+    %4:sreg_32 = S_MOV_B32 0
+    %14:vgpr_32 = COPY %4:sreg_32
+    %5:sreg_64_xexec = V_CMP_EQ_U32_e64 %0:vgpr_32, %14:vgpr_32, implicit $exec
+
+  bb.2:
+    %6:vgpr_32 = PHI %4:sreg_32, %bb.1, %11:vgpr_32, %bb.4
+    %8:sreg_64_xexec = SI_IF %5:sreg_64_xexec, %bb.3, implicit-def $exec, implicit-def $scc, implicit $exec
+    S_BRANCH %bb.4
+
+  bb.3:
+    SI_END_CF %8:sreg_64_xexec, implicit-def $exec, implicit-def $scc, implicit $exec
+    %13:sreg_32 = S_MOV_B32 1
+    %15:vgpr_32 = COPY %13:sreg_32
+    %10:vgpr_32, dead %20:sreg_64_xexec = V_ADD_CO_U32_e64 %6:vgpr_32, %15:vgpr_32, 0, implicit $exec
+
+  bb.4:
+    %11:vgpr_32 = PHI %10:vgpr_32, %bb.3, %6:vgpr_32, %bb.2
+    %16:sreg_32 = S_MOV_B32 4294967295
+    %17:sreg_32 = S_MOV_B32 61440
+    %18:sreg_64 = REG_SEQUENCE %16:sreg_32, %subreg.sub0, %17:sreg_32, %subreg.sub1
+    %19:sgpr_128 = REG_SEQUENCE %12:sreg_64, %subreg.sub0_sub1, %18:sreg_64, %subreg.sub2_sub3
+    BUFFER_STORE_DWORD_OFFSET %11:vgpr_32, %19:sgpr_128, 0, 0, 0, 0, implicit $exec
+    S_BRANCH %bb.2
+
+...