diff --git a/llvm/CMakeLists.txt b/llvm/CMakeLists.txt
--- a/llvm/CMakeLists.txt
+++ b/llvm/CMakeLists.txt
@@ -661,7 +661,12 @@
 endif()
 
 option(LLVM_OPTIMIZED_TABLEGEN "Force TableGen to be built with optimization" OFF)
-if(CMAKE_CROSSCOMPILING OR (LLVM_OPTIMIZED_TABLEGEN AND (LLVM_ENABLE_ASSERTIONS OR CMAKE_CONFIGURATION_TYPES)))
+if (LLVM_OPTIMIZED_TABLEGEN AND NOT CMAKE_CROSSCOMPILING AND CMAKE_GENERATOR STREQUAL "Ninja Multi-Config" AND "Release" IN_LIST CMAKE_CROSS_CONFIGS)
+  # "Ninja Multi-Config" generator allows using release tablegen binaries
+  # without needing a separate configured build directory for them.
+  set(LLVM_OPTIMIZED_TABLEGEN_VIA_NINJA_MULTI_CONFIG TRUE)
+endif()
+if(CMAKE_CROSSCOMPILING OR (LLVM_OPTIMIZED_TABLEGEN AND NOT LLVM_OPTIMIZED_TABLEGEN_VIA_NINJA_MULTI_CONFIG AND (LLVM_ENABLE_ASSERTIONS OR CMAKE_CONFIGURATION_TYPES)))
   set(LLVM_USE_HOST_TOOLS ON)
 endif()
 
diff --git a/llvm/cmake/modules/TableGen.cmake b/llvm/cmake/modules/TableGen.cmake
--- a/llvm/cmake/modules/TableGen.cmake
+++ b/llvm/cmake/modules/TableGen.cmake
@@ -96,6 +96,13 @@
   set(tablegen_exe ${${project}_TABLEGEN_EXE})
   set(tablegen_depends ${${project}_TABLEGEN_TARGET} ${tablegen_exe})
 
+  if (LLVM_OPTIMIZED_TABLEGEN_VIA_NINJA_MULTI_CONFIG)
+    set(tablegen_exe "${CMAKE_BINARY_DIR}/Release/bin/${${project}_TABLEGEN_EXE}")
+    # Only depend on the release executable; if we also depend on the target
+    # we'll build for both release and debug.
+    set(tablegen_depends ${tablegen_exe})
+  endif()
+
   add_custom_command(OUTPUT ${CMAKE_CURRENT_BINARY_DIR}/${ofn}
     COMMAND ${tablegen_exe} ${ARGN} -I ${CMAKE_CURRENT_SOURCE_DIR}
     ${tblgen_includes}