diff --git a/llvm/lib/Target/AVR/AVRExpandPseudoInsts.cpp b/llvm/lib/Target/AVR/AVRExpandPseudoInsts.cpp
--- a/llvm/lib/Target/AVR/AVRExpandPseudoInsts.cpp
+++ b/llvm/lib/Target/AVR/AVRExpandPseudoInsts.cpp
@@ -1318,8 +1318,8 @@
                  .addReg(DstReg)
                  .addReg(ZERO_REGISTER);
 
-  // SREG is always implicitly killed
-  MIB->getOperand(2).setIsKill();
+  MIB->getOperand(3).setIsDead(); // SREG is always dead
+  MIB->getOperand(4).setIsKill(); // SREG is always implicitly killed
 
   MI.eraseFromParent();
   return true;
diff --git a/llvm/lib/Target/AVR/AVRFrameLowering.cpp b/llvm/lib/Target/AVR/AVRFrameLowering.cpp
--- a/llvm/lib/Target/AVR/AVRFrameLowering.cpp
+++ b/llvm/lib/Target/AVR/AVRFrameLowering.cpp
@@ -56,6 +56,7 @@
   const AVRSubtarget &STI = MF.getSubtarget<AVRSubtarget>();
   const AVRInstrInfo &TII = *STI.getInstrInfo();
   const AVRMachineFunctionInfo *AFI = MF.getInfo<AVRMachineFunctionInfo>();
+  const MachineRegisterInfo &MRI = MF.getRegInfo();
   bool HasFP = hasFP(MF);
 
   // Interrupt handlers re-enable interrupts in function entry.
@@ -68,8 +69,8 @@
   // Emit special prologue code to save R1, R0 and SREG in interrupt/signal
   // handlers before saving any other registers.
   if (AFI->isInterruptOrSignalHandler()) {
-    BuildMI(MBB, MBBI, DL, TII.get(AVR::PUSHWRr))
-        .addReg(AVR::R1R0, RegState::Kill)
+    BuildMI(MBB, MBBI, DL, TII.get(AVR::PUSHRr))
+        .addReg(AVR::R0, RegState::Kill)
         .setMIFlag(MachineInstr::FrameSetup);
 
     BuildMI(MBB, MBBI, DL, TII.get(AVR::INRdA), AVR::R0)
@@ -78,11 +79,16 @@
     BuildMI(MBB, MBBI, DL, TII.get(AVR::PUSHRr))
         .addReg(AVR::R0, RegState::Kill)
         .setMIFlag(MachineInstr::FrameSetup);
-    BuildMI(MBB, MBBI, DL, TII.get(AVR::EORRdRr))
-        .addReg(AVR::R1, RegState::Define)
-        .addReg(AVR::R1, RegState::Kill)
-        .addReg(AVR::R1, RegState::Kill)
-        .setMIFlag(MachineInstr::FrameSetup);
+    if (!MRI.reg_empty(AVR::R1)) {
+      BuildMI(MBB, MBBI, DL, TII.get(AVR::PUSHRr))
+          .addReg(AVR::R1, RegState::Kill)
+          .setMIFlag(MachineInstr::FrameSetup);
+      BuildMI(MBB, MBBI, DL, TII.get(AVR::EORRdRr))
+          .addReg(AVR::R1, RegState::Define)
+          .addReg(AVR::R1, RegState::Kill)
+          .addReg(AVR::R1, RegState::Kill)
+          .setMIFlag(MachineInstr::FrameSetup);
+    }
   }
 
   // Early exit if the frame pointer is not needed in this function.
@@ -132,6 +138,7 @@
 
 static void restoreStatusRegister(MachineFunction &MF, MachineBasicBlock &MBB) {
   const AVRMachineFunctionInfo *AFI = MF.getInfo<AVRMachineFunctionInfo>();
+  const MachineRegisterInfo &MRI = MF.getRegInfo();
 
   MachineBasicBlock::iterator MBBI = MBB.getLastNonDebugInstr();
 
@@ -142,11 +149,14 @@
   // Emit special epilogue code to restore R1, R0 and SREG in interrupt/signal
   // handlers at the very end of the function, just before reti.
   if (AFI->isInterruptOrSignalHandler()) {
+    if (!MRI.reg_empty(AVR::R1)) {
+      BuildMI(MBB, MBBI, DL, TII.get(AVR::POPRd), AVR::R1);
+    }
     BuildMI(MBB, MBBI, DL, TII.get(AVR::POPRd), AVR::R0);
     BuildMI(MBB, MBBI, DL, TII.get(AVR::OUTARr))
         .addImm(STI.getIORegSREG())
         .addReg(AVR::R0, RegState::Kill);
-    BuildMI(MBB, MBBI, DL, TII.get(AVR::POPWRd), AVR::R1R0);
+    BuildMI(MBB, MBBI, DL, TII.get(AVR::POPRd), AVR::R0);
   }
 }
 
diff --git a/llvm/lib/Target/AVR/AVRISelDAGToDAG.cpp b/llvm/lib/Target/AVR/AVRISelDAGToDAG.cpp
--- a/llvm/lib/Target/AVR/AVRISelDAGToDAG.cpp
+++ b/llvm/lib/Target/AVR/AVRISelDAGToDAG.cpp
@@ -455,6 +455,10 @@
   SmallVector<SDValue, 8> Ops;
   Ops.push_back(CurDAG->getRegister(AVR::R31R30, MVT::i16));
 
+  // The R1 register must be passed as an implicit register so that R1 is
+  // correctly zeroed in interrupts.
+  Ops.push_back(CurDAG->getRegister(AVR::R1, MVT::i8));
+
   // Map all operands into the new node.
   for (unsigned i = 2, e = LastOpNum + 1; i != e; ++i) {
     Ops.push_back(N->getOperand(i));
diff --git a/llvm/lib/Target/AVR/AVRISelLowering.cpp b/llvm/lib/Target/AVR/AVRISelLowering.cpp
--- a/llvm/lib/Target/AVR/AVRISelLowering.cpp
+++ b/llvm/lib/Target/AVR/AVRISelLowering.cpp
@@ -57,6 +57,8 @@
   setOperationAction(ISD::DYNAMIC_STACKALLOC, MVT::i8, Expand);
   setOperationAction(ISD::DYNAMIC_STACKALLOC, MVT::i16, Expand);
 
+  setOperationAction(ISD::INLINEASM, MVT::Other, Custom);
+
   for (MVT VT : MVT::integer_valuetypes()) {
     for (auto N : {ISD::EXTLOAD, ISD::SEXTLOAD, ISD::ZEXTLOAD}) {
       setLoadExtAction(N, VT, MVT::i1, Promote);
@@ -817,6 +819,52 @@
                       MachinePointerInfo(SV));
 }
 
+// Modify the existing ISD::INLINEASM node to add the implicit register r1.
+SDValue AVRTargetLowering::LowerINLINEASM(SDValue Op, SelectionDAG &DAG) const {
+  SDValue R1Reg = DAG.getRegister(AVR::R1, MVT::i8);
+  if (Op.getOperand(Op.getNumOperands() - 1) == R1Reg ||
+      Op.getOperand(Op.getNumOperands() - 2) == R1Reg) {
+    // R1 has already been added. Don't add it again.
+    // If this isn't handled, we get called over and over again.
+    return Op;
+  }
+
+  // Get a list of operands to the new INLINEASM node. This is mostly a copy,
+  // with some edits.
+  // Add the following operands at the end (but before the glue node, if it's
+  // there):
+  //  - The flags of the implicit R1 register operand.
+  //  - The implicit R1 register operand itself.
+  SDLoc dl(Op);
+  SmallVector<SDValue, 8> Ops;
+  SDNode *N = Op.getNode();
+  SDValue Glue;
+  for (unsigned I = 0; I < N->getNumOperands(); I++) {
+    SDValue Operand = N->getOperand(I);
+    if (Operand.getValueType() == MVT::Glue) {
+      // The glue operand always needs to be at the end, so we need to treat it
+      // specially.
+      Glue = Operand;
+    } else {
+      Ops.push_back(Operand);
+    }
+  }
+  unsigned Flags = InlineAsm::getFlagWord(InlineAsm::Kind_RegUse, 1);
+  Ops.push_back(DAG.getTargetConstant(Flags, dl, MVT::i32));
+  Ops.push_back(R1Reg);
+  if (Glue) {
+    Ops.push_back(Glue);
+  }
+
+  // Replace the current INLINEASM node with a new one that has R1 as implicit
+  // parameter.
+  SDValue New = DAG.getNode(N->getOpcode(), dl, N->getVTList(), Ops);
+  DAG.ReplaceAllUsesOfValueWith(Op, New);
+  DAG.ReplaceAllUsesOfValueWith(Op.getValue(1), New.getValue(1));
+
+  return New;
+}
+
 SDValue AVRTargetLowering::LowerOperation(SDValue Op, SelectionDAG &DAG) const {
   switch (Op.getOpcode()) {
   default:
@@ -842,6 +890,8 @@
   case ISD::SDIVREM:
   case ISD::UDIVREM:
     return LowerDivRem(Op, DAG);
+  case ISD::INLINEASM:
+    return LowerINLINEASM(Op, DAG);
   }
 
   return SDValue();
@@ -1432,6 +1482,10 @@
     Ops.push_back(DAG.getRegister(Reg.first, Reg.second.getValueType()));
   }
 
+  // The R1 register must be passed as an implicit register so that R1 is
+  // correctly zeroed in interrupts.
+  Ops.push_back(DAG.getRegister(AVR::R1, MVT::i8));
+
   // Add a register mask operand representing the call-preserved registers.
   const TargetRegisterInfo *TRI = Subtarget.getRegisterInfo();
   const uint32_t *Mask =
@@ -1553,6 +1607,14 @@
 
   const AVRMachineFunctionInfo *AFI = MF.getInfo<AVRMachineFunctionInfo>();
 
+  if (!AFI->isInterruptOrSignalHandler()) {
+    // The return instruction has an implicit R1 operand: it must contain zero
+    // on return.
+    // This is not needed in interrupts however, where R1 is handled specially
+    // (only pushed/popped when needed).
+    RetOps.push_back(DAG.getRegister(AVR::R1, MVT::i8));
+  }
+
   unsigned RetOpc =
       AFI->isInterruptOrSignalHandler() ? AVRISD::RETI_FLAG : AVRISD::RET_FLAG;
 
diff --git a/llvm/lib/Target/AVR/AVRInstrInfo.td b/llvm/lib/Target/AVR/AVRInstrInfo.td
--- a/llvm/lib/Target/AVR/AVRInstrInfo.td
+++ b/llvm/lib/Target/AVR/AVRInstrInfo.td
@@ -911,6 +911,7 @@
   // neg Rd+1
   // neg Rd
   // sbc Rd+1, r1
+  let Uses = [R1] in
   def NEGWRd : Pseudo<(outs DREGS
                        : $rd),
                       (ins DREGS
@@ -1982,6 +1983,7 @@
   def ASRWLoRd : Pseudo<(outs DREGS:$rd), (ins DREGS:$src), "asrwlo\t$rd",
                         [(set i16:$rd, (AVRasrlo i16:$src)), (implicit SREG)]>;
 
+  let Uses = [R1] in
   def ROLBRd : Pseudo<(outs GPR8
                        : $rd),
                       (ins GPR8
diff --git a/llvm/test/CodeGen/AVR/interrupts.ll b/llvm/test/CodeGen/AVR/interrupts.ll
--- a/llvm/test/CodeGen/AVR/interrupts.ll
+++ b/llvm/test/CodeGen/AVR/interrupts.ll
@@ -6,13 +6,10 @@
 ; CHECK-LABEL: interrupt_handler:
 ; CHECK: sei
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   ret void
@@ -22,13 +19,10 @@
 ; CHECK-LABEL: interrupt_handler_via_ir_attribute:
 ; CHECK: sei
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   ret void
@@ -38,13 +32,10 @@
 ; CHECK-LABEL: signal_handler:
 ; CHECK-NOT: sei
 ; CHECK: push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   ret void
@@ -54,13 +45,10 @@
 ; CHECK-LABEL: signal_handler_via_attribute:
 ; CHECK-NOT: sei
 ; CHECK: push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   ret void
@@ -70,10 +58,8 @@
 ; CHECK-LABEL: interrupt_alloca:
 ; CHECK: sei
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK: push r28
 ; CHECK-NEXT: push r29
 ; CHECK-NEXT: in r28, 61
@@ -94,7 +80,6 @@
 ; CHECK-NEXT: pop r28
 ; CHECK: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   alloca i8
@@ -104,10 +89,8 @@
 define void @signal_handler_with_increment() #1 {
 ; CHECK-LABEL: signal_handler_with_increment:
 ; CHECK:      push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
-; CHECK-NEXT: clr r1
 ; CHECK-NEXT: push r24
 ; CHECK-NEXT: lds r24, count
 ; CHECK-NEXT: inc r24
@@ -115,7 +98,6 @@
 ; CHECK-NEXT: pop r24
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   %old = load volatile i8, i8* @count
@@ -124,6 +106,29 @@
   ret void
 }
 
+; Check that r1 is saved/restored and set to 0 when using inline assembly.
+define void @signal_handler_with_asm() #1 {
+; CHECK-LABEL: signal_handler_with_asm:
+; CHECK:      push r0
+; CHECK-NEXT: in r0, 63
+; CHECK-NEXT: push r0
+; CHECK-NEXT: push r1
+; CHECK-NEXT: clr r1
+; CHECK-NEXT: push r24
+; CHECK-NEXT: ldi
+;             ;APP
+; CHECK:      mov
+;             ;NO_APP
+; CHECK:      pop r24
+; CHECK-NEXT: pop r1
+; CHECK-NEXT: pop r0
+; CHECK-NEXT: out 63, r0
+; CHECK-NEXT: pop r0
+; CHECK-NEXT: reti
+  call i8 asm sideeffect "mov $0, $1", "=r,r"(i8 3) nounwind
+  ret void
+}
+
 declare void @foo()
 
 ; When a signal handler calls a function, it must push/pop all call clobbered
@@ -131,9 +136,9 @@
 define void @signal_handler_with_call() #1 {
 ; CHECK-LABEL: signal_handler_with_call:
 ; CHECK:      push r0
-; CHECK-NEXT: push r1
 ; CHECK-NEXT: in r0, 63
 ; CHECK-NEXT: push r0
+; CHECK-NEXT: push r1
 ; CHECK-NEXT: clr r1
 ; CHECK-NEXT: push r18
 ; CHECK-NEXT: push r19
@@ -160,9 +165,9 @@
 ; CHECK-NEXT: pop r20
 ; CHECK-NEXT: pop r19
 ; CHECK-NEXT: pop r18
+; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: out 63, r0
-; CHECK-NEXT: pop r1
 ; CHECK-NEXT: pop r0
 ; CHECK-NEXT: reti
   call void @foo()
diff --git a/llvm/test/CodeGen/AVR/pseudo/NEGWRd.mir b/llvm/test/CodeGen/AVR/pseudo/NEGWRd.mir
--- a/llvm/test/CodeGen/AVR/pseudo/NEGWRd.mir
+++ b/llvm/test/CodeGen/AVR/pseudo/NEGWRd.mir
@@ -22,5 +22,5 @@
     ; CHECK-NEXT: $r14 = NEGRd $r14
     ; CHECK-NEXT: $r15 = SBCRdRr $r15, $r1, implicit-def $sreg, implicit killed $sreg
 
-    $r15r14 = NEGWRd $r15r14, implicit-def $sreg
+    $r15r14 = NEGWRd $r15r14, implicit-def $sreg, implicit $r1
 ...
diff --git a/llvm/test/CodeGen/AVR/pseudo/ROLBrd.mir b/llvm/test/CodeGen/AVR/pseudo/ROLBrd.mir
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AVR/pseudo/ROLBrd.mir
@@ -0,0 +1,25 @@
+# RUN: llc -O0 -run-pass=avr-expand-pseudo %s -o - | FileCheck %s
+
+# This test checks the expansion of the 8-bit ROLB (rotate) pseudo instruction.
+
+--- |
+  target triple = "avr--"
+  define void @test_rolbrd() {
+  entry:
+    ret void
+  }
+...
+
+---
+name:            test_rolbrd
+body: |
+  bb.0.entry:
+    liveins: $r14
+
+    ; CHECK-LABEL: test_rolbrd
+
+    ; CHECK:      $r14 = ADDRdRr $r14, $r14, implicit-def $sreg
+    ; CHECK-NEXT: $r14 = ADCRdRr $r14, $r1, implicit-def dead $sreg, implicit killed $sreg
+
+    $r14 = ROLBRd $r14, implicit-def $sreg, implicit $r1
+...
diff --git a/llvm/test/CodeGen/AVR/zeroreg.ll b/llvm/test/CodeGen/AVR/zeroreg.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/AVR/zeroreg.ll
@@ -0,0 +1,27 @@
+; RUN: llc -mattr=avr6,sram < %s -march=avr | FileCheck %s
+
+; This file tests whether the compiler correctly works with the r1 register,
+; clearing it when needed.
+
+; Test regular use of r1 as a zero register.
+; CHECK-LABEL: store8zero:
+; CHECK:      st {{[XYZ]}}, r1
+; CHECK-NEXT: mov r24, r1
+; CHECK-NEXT: ret
+define i8 @store8zero(i8* %x) {
+  store i8 0, i8* %x
+  ret i8 0
+}
+
+; Test that mulitplication instructions (mul, muls, etc) clobber r1 and require
+; a "clr r1" instruction.
+; CHECK-LABEL: mul:
+; CHECK:      muls
+; CHECK-NEXT: clr r1
+; CHECK-NEXT: st {{[XYZ]}}, r0
+; CHECK-NEXT: ret
+define void @mul(i8* %ptr, i8 %n) {
+  %result = mul i8 %n, 3
+  store i8 %result, i8* %ptr
+  ret void
+}