diff --git a/llvm/cmake/modules/HandleLLVMOptions.cmake b/llvm/cmake/modules/HandleLLVMOptions.cmake
--- a/llvm/cmake/modules/HandleLLVMOptions.cmake
+++ b/llvm/cmake/modules/HandleLLVMOptions.cmake
@@ -315,12 +315,11 @@
     # Note: GCC<10.3 has a bug on SystemZ.
     #
     # Note: Clang allows IPO for -fPIC so this optimization is less effective.
-    # Older Clang may support -fno-semantic-interposition but it used local
-    # aliases to optimize global variables, which is incompatible with copy
-    # relocations due to -fno-pic.
+    # Clang 13 has a bug related to -fsanitize-coverage
+    # -fno-semantic-interposition (https://reviews.llvm.org/D117183).
     if ((CMAKE_COMPILER_IS_GNUCXX AND
          NOT (LLVM_NATIVE_ARCH STREQUAL "SystemZ" AND CMAKE_CXX_COMPILER_VERSION VERSION_LESS 10.3))
-       OR (CMAKE_CXX_COMPILER_ID MATCHES "Clang" AND CMAKE_CXX_COMPILER_VERSION GREATER_EQUAL 13))
+       OR (CMAKE_CXX_COMPILER_ID MATCHES "Clang" AND CMAKE_CXX_COMPILER_VERSION GREATER_EQUAL 14))
       add_flag_if_supported("-fno-semantic-interposition" FNO_SEMANTIC_INTERPOSITION)
     endif()
   endif()