diff --git a/mlir/lib/Bindings/Python/IRCore.cpp b/mlir/lib/Bindings/Python/IRCore.cpp
--- a/mlir/lib/Bindings/Python/IRCore.cpp
+++ b/mlir/lib/Bindings/Python/IRCore.cpp
@@ -868,7 +868,6 @@
     mlirOpPrintingFlagsPrintGenericOpForm(flags);
 
   PyFileAccumulator accum(fileObject, binary);
-  py::gil_scoped_release();
   mlirOperationPrintWithFlags(operation, flags, accum.getCallback(),
                               accum.getUserData());
   mlirOpPrintingFlagsDestroy(flags);
diff --git a/mlir/lib/Bindings/Python/IRModule.cpp b/mlir/lib/Bindings/Python/IRModule.cpp
--- a/mlir/lib/Bindings/Python/IRModule.cpp
+++ b/mlir/lib/Bindings/Python/IRModule.cpp
@@ -35,7 +35,6 @@
 PyGlobals::~PyGlobals() { instance = nullptr; }
 
 void PyGlobals::loadDialectModule(llvm::StringRef dialectNamespace) {
-  py::gil_scoped_acquire();
   if (loadedDialectModulesCache.contains(dialectNamespace))
     return;
   // Since re-entrancy is possible, make a copy of the search prefixes.
@@ -46,7 +45,6 @@
     moduleName.append(dialectNamespace.data(), dialectNamespace.size());
 
     try {
-      py::gil_scoped_release();
       loaded = py::module::import(moduleName.c_str());
     } catch (py::error_already_set &e) {
       if (e.matches(PyExc_ModuleNotFoundError)) {
@@ -64,7 +62,6 @@
 
 void PyGlobals::registerDialectImpl(const std::string &dialectNamespace,
                                     py::object pyClass) {
-  py::gil_scoped_acquire();
   py::object &found = dialectClassMap[dialectNamespace];
   if (found) {
     throw SetPyError(PyExc_RuntimeError, llvm::Twine("Dialect namespace '") +
@@ -77,7 +74,6 @@
 void PyGlobals::registerOperationImpl(const std::string &operationName,
                                       py::object pyClass,
                                       py::object rawOpViewClass) {
-  py::gil_scoped_acquire();
   py::object &found = operationClassMap[operationName];
   if (found) {
     throw SetPyError(PyExc_RuntimeError, llvm::Twine("Operation '") +
@@ -90,7 +86,6 @@
 
 llvm::Optional<py::object>
 PyGlobals::lookupDialectClass(const std::string &dialectNamespace) {
-  py::gil_scoped_acquire();
   loadDialectModule(dialectNamespace);
   // Fast match against the class map first (common case).
   const auto foundIt = dialectClassMap.find(dialectNamespace);
@@ -109,7 +104,6 @@
 llvm::Optional<pybind11::object>
 PyGlobals::lookupRawOpViewClass(llvm::StringRef operationName) {
   {
-    py::gil_scoped_acquire();
     auto foundIt = rawOpViewClassMapCache.find(operationName);
     if (foundIt != rawOpViewClassMapCache.end()) {
       if (foundIt->second.is_none())
@@ -126,7 +120,6 @@
 
   // Attempt to find from the canonical map and cache.
   {
-    py::gil_scoped_acquire();
     auto foundIt = rawOpViewClassMap.find(operationName);
     if (foundIt != rawOpViewClassMap.end()) {
       if (foundIt->second.is_none())
@@ -143,7 +136,6 @@
 }
 
 void PyGlobals::clearImportCache() {
-  py::gil_scoped_acquire();
   loadedDialectModulesCache.clear();
   rawOpViewClassMapCache.clear();
 }