diff --git a/clang/include/clang/Basic/AttrDocs.td b/clang/include/clang/Basic/AttrDocs.td
--- a/clang/include/clang/Basic/AttrDocs.td
+++ b/clang/include/clang/Basic/AttrDocs.td
@@ -6205,6 +6205,10 @@
 
 Does not guarantee that inline substitution actually occurs.
 
+<ins>Note: applying this attribute to a coroutine at the `-O0` optimization level
+has no effect; other optimization levels may only partially inline and result in a
+diagnostic.</ins>
+
 See also `the Microsoft Docs on Inline Functions`_, `the GCC Common Function
 Attribute docs`_, and `the GCC Inline docs`_.
 
diff --git a/clang/include/clang/Basic/DiagnosticGroups.td b/clang/include/clang/Basic/DiagnosticGroups.td
--- a/clang/include/clang/Basic/DiagnosticGroups.td
+++ b/clang/include/clang/Basic/DiagnosticGroups.td
@@ -58,7 +58,9 @@
   DiagGroup<"deprecated-experimental-coroutine">;
 def DeprecatedCoroutine :
   DiagGroup<"deprecated-coroutine", [DeprecatedExperimentalCoroutine]>;
-def Coroutine : DiagGroup<"coroutine", [CoroutineMissingUnhandledException, DeprecatedCoroutine]>;
+def AlwaysInlineCoroutine :
+  DiagGroup<"always-inline-coroutine">;
+def Coroutine : DiagGroup<"coroutine", [CoroutineMissingUnhandledException, DeprecatedCoroutine, AlwaysInlineCoroutine]>;
 def ObjCBoolConstantConversion : DiagGroup<"objc-bool-constant-conversion">;
 def ConstantConversion : DiagGroup<"constant-conversion",
                                    [BitFieldConstantConversion,
diff --git a/clang/include/clang/Basic/DiagnosticSemaKinds.td b/clang/include/clang/Basic/DiagnosticSemaKinds.td
--- a/clang/include/clang/Basic/DiagnosticSemaKinds.td
+++ b/clang/include/clang/Basic/DiagnosticSemaKinds.td
@@ -11122,6 +11122,10 @@
 def note_coroutine_function_declare_noexcept : Note<
   "must be declared with 'noexcept'"
 >;
+def warn_always_inline_coroutine : Warning<
+  "this coroutine may be split into pieces; not every piece is guaranteed to be inlined"
+  >,
+  InGroup<AlwaysInlineCoroutine>;
 } // end of coroutines issue category
 
 let CategoryName = "Documentation Issue" in {
diff --git a/clang/lib/Sema/SemaCoroutine.cpp b/clang/lib/Sema/SemaCoroutine.cpp
--- a/clang/lib/Sema/SemaCoroutine.cpp
+++ b/clang/lib/Sema/SemaCoroutine.cpp
@@ -1081,6 +1081,14 @@
     return;
   }
 
+  // The always_inline attribute doesn't reliably apply to a coroutine,
+  // because the coroutine will be split into pieces and some pieces
+  // might be called indirectly, as in a virtual call. Even the ramp
+  // function cannot be inlined at -O0, due to pipeline ordering
+  // problems (see https://llvm.org/PR53413). Tell the user about it.
+  if (FD->hasAttr<AlwaysInlineAttr>())
+    Diag(FD->getLocation(), diag::warn_always_inline_coroutine);
+
   // [stmt.return.coroutine]p1:
   //   A coroutine shall not enclose a return statement ([stmt.return]).
   if (Fn->FirstReturnLoc.isValid()) {
diff --git a/clang/test/SemaCXX/coroutines.cpp b/clang/test/SemaCXX/coroutines.cpp
--- a/clang/test/SemaCXX/coroutines.cpp
+++ b/clang/test/SemaCXX/coroutines.cpp
@@ -1460,3 +1460,13 @@
   co_await missing_await_suspend{}; // expected-error {{no member named 'await_suspend' in 'missing_await_suspend'}}
   co_await missing_await_resume{}; // expected-error {{no member named 'await_resume' in 'missing_await_resume'}}
 }
+
+__attribute__((__always_inline__))
+void warn_always_inline() { // expected-warning {{this coroutine may be split into pieces; not every piece is guaranteed to be inlined}}
+  co_await suspend_always{};
+}
+
+[[gnu::always_inline]]
+void warn_gnu_always_inline() { // expected-warning {{this coroutine may be split into pieces; not every piece is guaranteed to be inlined}}
+  co_await suspend_always{};
+}