diff --git a/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp b/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
--- a/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
+++ b/llvm/lib/Transforms/Scalar/MemCpyOptimizer.cpp
@@ -20,6 +20,7 @@
 #include "llvm/ADT/iterator_range.h"
 #include "llvm/Analysis/AliasAnalysis.h"
 #include "llvm/Analysis/AssumptionCache.h"
+#include "llvm/Analysis/CaptureTracking.h"
 #include "llvm/Analysis/GlobalsModRef.h"
 #include "llvm/Analysis/Loads.h"
 #include "llvm/Analysis/MemoryLocation.h"
@@ -945,12 +946,56 @@
       return false;
   }
 
-  // Check that src isn't captured by the called function since the
-  // transformation can cause aliasing issues in that case.
-  for (unsigned ArgI = 0, E = C->arg_size(); ArgI != E; ++ArgI)
-    if (C->getArgOperand(ArgI) == cpySrc && !C->doesNotCapture(ArgI))
+  // Check whether src is captured by the called function, in which case there
+  // may be further indirect uses of src.
+  bool SrcIsCaptured = any_of(C->args(), [&](Use &U) {
+    return U == cpySrc && !C->doesNotCapture(C->getArgOperandNo(&U));
+  });
+
+  // If src is captured, then check whether there are any potential uses of
+  // src through the captured pointer before the lifetime of src ends, either
+  // due to a lifetime.end or a return from the function.
+  if (SrcIsCaptured) {
+    // Check that dest is not captured before/at the call. We have already
+    // checked that src is not captured before it. If either had been captured,
+    // then the call might be comparing the argument against the captured dest
+    // or src pointer.
+    Value *DestObj = getUnderlyingObject(cpyDest);
+    if (!isIdentifiedFunctionLocal(DestObj) ||
+        PointerMayBeCapturedBefore(DestObj, /* ReturnCaptures */ true,
+                                   /* StoreCaptures */ true, C, DT,
+                                   /* IncludeI */ true))
       return false;
 
+    MemoryLocation SrcLoc =
+        MemoryLocation(srcAlloca, LocationSize::precise(srcSize));
+    for (Instruction &I :
+         make_range(++C->getIterator(), C->getParent()->end())) {
+      // Lifetime of srcAlloca ends at lifetime.end.
+      if (auto *II = dyn_cast<IntrinsicInst>(&I)) {
+        if (II->getIntrinsicID() == Intrinsic::lifetime_end &&
+            II->getArgOperand(1)->stripPointerCasts() == srcAlloca &&
+            cast<ConstantInt>(II->getArgOperand(0))->uge(srcSize))
+          break;
+      }
+
+      // Lifetime of srcAlloca ends at return.
+      if (isa<ReturnInst>(&I))
+        break;
+
+      // Ignore the direct read of src in the load.
+      if (&I == cpyLoad)
+        continue;
+
+      // Check whether this instruction may mod/ref src through the captured
+      // pointer (we have already any direct mod/refs in the loop above).
+      // Also bail if we hit a terminator, as we don't want to scan into other
+      // blocks.
+      if (isModOrRefSet(AA->getModRefInfo(&I, SrcLoc)) || I.isTerminator())
+        return false;
+    }
+  }
+
   // Since we're changing the parameter to the callsite, we need to make sure
   // that what would be the new parameter dominates the callsite.
   if (!DT->dominates(cpyDest, C)) {
diff --git a/llvm/test/Transforms/MemCpyOpt/capturing-func.ll b/llvm/test/Transforms/MemCpyOpt/capturing-func.ll
--- a/llvm/test/Transforms/MemCpyOpt/capturing-func.ll
+++ b/llvm/test/Transforms/MemCpyOpt/capturing-func.ll
@@ -57,8 +57,7 @@
 ; CHECK-NEXT:    [[PTR1:%.*]] = alloca i8, align 1
 ; CHECK-NEXT:    [[PTR2:%.*]] = alloca i8, align 1
 ; CHECK-NEXT:    call void @llvm.lifetime.start.p0i8(i64 1, i8* [[PTR2]])
-; CHECK-NEXT:    call void @foo(i8* [[PTR2]])
-; CHECK-NEXT:    call void @llvm.memcpy.p0i8.p0i8.i32(i8* [[PTR1]], i8* [[PTR2]], i32 1, i1 false)
+; CHECK-NEXT:    call void @foo(i8* [[PTR1]])
 ; CHECK-NEXT:    call void @llvm.lifetime.end.p0i8(i64 1, i8* [[PTR2]])
 ; CHECK-NEXT:    call void @foo(i8* [[PTR1]])
 ; CHECK-NEXT:    ret void
@@ -101,8 +100,7 @@
 ; CHECK-LABEL: define {{[^@]+}}@test_function_end() {
 ; CHECK-NEXT:    [[PTR1:%.*]] = alloca i8, align 1
 ; CHECK-NEXT:    [[PTR2:%.*]] = alloca i8, align 1
-; CHECK-NEXT:    call void @foo(i8* [[PTR2]])
-; CHECK-NEXT:    call void @llvm.memcpy.p0i8.p0i8.i32(i8* [[PTR1]], i8* [[PTR2]], i32 1, i1 false)
+; CHECK-NEXT:    call void @foo(i8* [[PTR1]])
 ; CHECK-NEXT:    ret void
 ;
   %ptr1 = alloca i8