Index: clang/lib/Frontend/InitPreprocessor.cpp
===================================================================
--- clang/lib/Frontend/InitPreprocessor.cpp
+++ clang/lib/Frontend/InitPreprocessor.cpp
@@ -512,6 +512,8 @@
     Builder.defineMacro("__HIP_MEMORY_SCOPE_SYSTEM", "5");
     if (LangOpts.CUDAIsDevice)
       Builder.defineMacro("__HIP_DEVICE_COMPILE__");
+    if (LangOpts.GPURelocatableDeviceCode)
+      Builder.defineMacro("__HIPCC_RDC__");
   }
 }
 
Index: clang/test/Preprocessor/predefined-macros.c
===================================================================
--- clang/test/Preprocessor/predefined-macros.c
+++ clang/test/Preprocessor/predefined-macros.c
@@ -224,17 +224,33 @@
 // CHECK-SPIRV64-DAG: #define __SPIRV64__ 1
 // CHECK-SPIRV64-NOT: #define __SPIRV32__ 1
 
-// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple amdgcn-amd-amdhsa      \
+// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple x86_64-unknown-linux-gnu \
 // RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP
-// CHECK-HIP-NOT: #define __CUDA_ARCH__
 // CHECK-HIP: #define __HIPCC__ 1
-// CHECK-HIP-NOT: #define __HIP_DEVICE_COMPILE__ 1
 // CHECK-HIP: #define __HIP__ 1
 
+// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple x86_64-unknown-linux-gnu \
+// RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP-NEG
+// CHECK-HIP-NEG-NOT: #define __CUDA_ARCH__
+// CHECK-HIP-NEG-NOT: #define __HIP_DEVICE_COMPILE__ 1
+// CHECK-HIP-NEG-NOT: #define __HIPCC_RDC__ 1
+
 // RUN: %clang_cc1 %s -E -dM -o - -x hip -triple amdgcn-amd-amdhsa \
 // RUN:   -fcuda-is-device \
 // RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP-DEV
-// CHECK-HIP-DEV-NOT: #define __CUDA_ARCH__
 // CHECK-HIP-DEV: #define __HIPCC__ 1
 // CHECK-HIP-DEV: #define __HIP_DEVICE_COMPILE__ 1
 // CHECK-HIP-DEV: #define __HIP__ 1
+
+// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple amdgcn-amd-amdhsa \
+// RUN:   -fcuda-is-device \
+// RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP-DEV-NEG
+// CHECK-HIP-DEV-NEG-NOT: #define __CUDA_ARCH__
+// CHECK-HIP-DEV-NEG-NOT: #define __HIPCC_RDC__ 1
+
+// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple x86_64-unknown-linux-gnu \
+// RUN:   -fgpu-rdc | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP-RDC
+// RUN: %clang_cc1 %s -E -dM -o - -x hip -triple amdgcn-amd-amdhsa \
+// RUN:   -fgpu-rdc -fcuda-is-device \
+// RUN:   | FileCheck -match-full-lines %s --check-prefix=CHECK-HIP-RDC
+// CHECK-HIP-RDC: #define __HIPCC_RDC__ 1