diff --git a/llvm/test/tools/llvm-reduce/operands-to-args-metadata.ll b/llvm/test/tools/llvm-reduce/operands-to-args-metadata.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/tools/llvm-reduce/operands-to-args-metadata.ll
@@ -0,0 +1,31 @@
+; RUN: llvm-reduce %s -o %t --delta-passes=operands-to-args --test FileCheck --test-arg %s --test-arg --input-file
+
+; CHECK: @foo
+
+define void @foo() !dbg !7 {
+entry:
+  %a = alloca i32
+  call void @llvm.dbg.declare(metadata i32* %a, metadata !13, metadata !DIExpression()), !dbg !14
+  ret void
+}
+
+declare void @llvm.dbg.declare(metadata, metadata, metadata) #0
+
+!llvm.dbg.cu = !{!0}
+!llvm.module.flags = !{!2, !3, !4, !5, !6}
+
+!0 = distinct !DICompileUnit(language: DW_LANG_C99, file: !1, producer: "clang version 14.0.0", isOptimized: false, runtimeVersion: 0, emissionKind: FullDebug, splitDebugInlining: false, nameTableKind: None)
+!1 = !DIFile(filename: "/tmp/a.c", directory: "/")
+!2 = !{i32 7, !"Dwarf Version", i32 4}
+!3 = !{i32 2, !"Debug Info Version", i32 3}
+!4 = !{i32 1, !"wchar_size", i32 4}
+!5 = !{i32 7, !"uwtable", i32 1}
+!6 = !{i32 7, !"frame-pointer", i32 2}
+!7 = distinct !DISubprogram(name: "main", scope: !8, file: !8, line: 1, type: !9, scopeLine: 1, spFlags: DISPFlagDefinition, unit: !0, retainedNodes: !12)
+!8 = !DIFile(filename: "/tmp/a.c", directory: "")
+!9 = !DISubroutineType(types: !10)
+!10 = !{!11}
+!11 = !DIBasicType(name: "int", size: 32, encoding: DW_ATE_signed)
+!12 = !{}
+!13 = !DILocalVariable(name: "a", scope: !7, file: !8, line: 2, type: !11)
+!14 = !DILocation(line: 2, column: 7, scope: !7)
diff --git a/llvm/test/tools/llvm-reduce/remove-operands.ll b/llvm/test/tools/llvm-reduce/remove-operands.ll
--- a/llvm/test/tools/llvm-reduce/remove-operands.ll
+++ b/llvm/test/tools/llvm-reduce/remove-operands.ll
@@ -18,6 +18,8 @@
 
 %t = type { i32, i8 }
 
+declare void @llvm.foo(metadata)
+
 ; CHECK-LABEL: define i32 @main
 define i32 @main(%t* %a, i32 %a2) {
 
@@ -41,6 +43,7 @@
   %i2 = inttoptr i16 1 to i8*
   %i3 = inttoptr i16 2 to i8*
   %i4 = inttoptr i16 undef to i8*
+  call void @llvm.foo(metadata %t* %a)
   br label %lb2
 
 ; CHECK-LABEL: lb2:
diff --git a/llvm/tools/llvm-reduce/deltas/ReduceOperands.cpp b/llvm/tools/llvm-reduce/deltas/ReduceOperands.cpp
--- a/llvm/tools/llvm-reduce/deltas/ReduceOperands.cpp
+++ b/llvm/tools/llvm-reduce/deltas/ReduceOperands.cpp
@@ -9,6 +9,7 @@
 #include "ReduceOperands.h"
 #include "llvm/IR/Constants.h"
 #include "llvm/IR/InstIterator.h"
+#include "llvm/IR/InstrTypes.h"
 #include "llvm/IR/Operator.h"
 #include "llvm/IR/Type.h"
 
@@ -52,12 +53,25 @@
   return C && C->isNullValue();
 }
 
+static bool shouldReduceOperand(Use &Op) {
+  Type *Ty = Op->getType();
+  if (Ty->isLabelTy() || Ty->isMetadataTy())
+    return false;
+  // TODO: be more precise about which GEP operands we can reduce (e.g. array
+  // indexes)
+  if (isa<GEPOperator>(Op.getUser()))
+    return false;
+  if (auto *CB = dyn_cast<CallBase>(Op.getUser())) {
+    if (&CB->getCalledOperandUse() == &Op)
+      return false;
+  }
+  return true;
+}
+
 void llvm::reduceOperandsUndefDeltaPass(TestRunner &Test) {
   errs() << "*** Reducing Operands to undef...\n";
   auto ReduceValue = [](Use &Op) -> Value * {
-    if (isa<GEPOperator>(Op.getUser()))
-      return nullptr;
-    if (Op->getType()->isLabelTy())
+    if (!shouldReduceOperand(Op))
       return nullptr;
     // Don't replace existing ConstantData Uses.
     return isa<ConstantData>(*Op) ? nullptr : UndefValue::get(Op->getType());
@@ -72,7 +86,7 @@
   errs() << "*** Reducing Operands to one...\n";
   auto ReduceValue = [](Use &Op) -> Value * {
     // TODO: support floats
-    if (isa<GEPOperator>(Op.getUser()))
+    if (!shouldReduceOperand(Op))
       return nullptr;
     auto *Ty = dyn_cast<IntegerType>(Op->getType());
     if (!Ty)
@@ -89,11 +103,7 @@
 void llvm::reduceOperandsZeroDeltaPass(TestRunner &Test) {
   errs() << "*** Reducing Operands to zero...\n";
   auto ReduceValue = [](Use &Op) -> Value * {
-    // TODO: be more precise about which GEP operands we can reduce (e.g. array
-    // indexes)
-    if (isa<GEPOperator>(Op.getUser()))
-      return nullptr;
-    if (Op->getType()->isLabelTy())
+    if (!shouldReduceOperand(Op))
       return nullptr;
     // Don't replace existing zeroes.
     return isZero(Op) ? nullptr : Constant::getNullValue(Op->getType());
diff --git a/llvm/tools/llvm-reduce/deltas/ReduceOperandsToArgs.cpp b/llvm/tools/llvm-reduce/deltas/ReduceOperandsToArgs.cpp
--- a/llvm/tools/llvm-reduce/deltas/ReduceOperandsToArgs.cpp
+++ b/llvm/tools/llvm-reduce/deltas/ReduceOperandsToArgs.cpp
@@ -33,8 +33,8 @@
   if (!Ty->isFirstClassType())
     return false;
 
-  // Don't pass labels as arguments.
-  if (Ty->isLabelTy())
+  // Don't pass labels/metadata as arguments.
+  if (Ty->isLabelTy() || Ty->isMetadataTy())
     return false;
 
   // No need to replace values that are already arguments.