diff --git a/llvm/lib/Target/PowerPC/PPCRegisterInfo.h b/llvm/lib/Target/PowerPC/PPCRegisterInfo.h
--- a/llvm/lib/Target/PowerPC/PPCRegisterInfo.h
+++ b/llvm/lib/Target/PowerPC/PPCRegisterInfo.h
@@ -91,6 +91,8 @@
   void adjustStackMapLiveOutMask(uint32_t *Mask) const override;
 
   BitVector getReservedRegs(const MachineFunction &MF) const override;
+  bool isAsmClobberable(const MachineFunction &MF,
+                        MCRegister PhysReg) const override;
   bool isCallerPreservedPhysReg(MCRegister PhysReg,
                                 const MachineFunction &MF) const override;
 
diff --git a/llvm/lib/Target/PowerPC/PPCRegisterInfo.cpp b/llvm/lib/Target/PowerPC/PPCRegisterInfo.cpp
--- a/llvm/lib/Target/PowerPC/PPCRegisterInfo.cpp
+++ b/llvm/lib/Target/PowerPC/PPCRegisterInfo.cpp
@@ -390,6 +390,18 @@
   return Reserved;
 }
 
+bool PPCRegisterInfo::isAsmClobberable(const MachineFunction &MF,
+                                       MCRegister PhysReg) const {
+  // We cannot use getReservedRegs() to find the registers that are not asm
+  // clobberable because there are some reserved registers which can be
+  // clobbered by inline asm. For example, when LR is clobbered, the register is
+  // saved and restored. We will harcode the registers that are not asm
+  // cloberable in this function.
+
+  // The stack pointer (X1/R1) is not clobberable by inline asm
+  return PhysReg != (TM.isPPC64() ? PPC::X1 : PPC::R1);
+}
+
 bool PPCRegisterInfo::requiresFrameIndexScavenging(const MachineFunction &MF) const {
   const PPCSubtarget &Subtarget = MF.getSubtarget<PPCSubtarget>();
   const PPCInstrInfo *InstrInfo =  Subtarget.getInstrInfo();
diff --git a/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning-64.ll b/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning-64.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning-64.ll
@@ -0,0 +1,10 @@
+; RUN: llc < %s -verify-machineinstrs -mtriple=powerpc64-unknown-unkown \
+; RUN:   -mcpu=pwr7 2>&1 | FileCheck %s
+
+; CHECK: warning: inline asm clobber list contains reserved registers: X1
+; CHECK-NEXT: note: Reserved registers on the clobber list may not be preserved across the asm statement, and clobbering them may lead to undefined behaviour.
+define void @test_r1_clobber() {
+entry:
+  call void asm sideeffect "nop", "~{x1}"()
+  ret void
+}
diff --git a/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning.ll b/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/CodeGen/PowerPC/inline-asm-clobber-warning.ll
@@ -0,0 +1,10 @@
+; RUN: llc < %s -verify-machineinstrs -mtriple=powerpc-unknown-unkown \
+; RUN:   -mcpu=pwr7 2>&1 | FileCheck %s
+
+; CHECK: warning: inline asm clobber list contains reserved registers: R1
+; CHECK-NEXT: note: Reserved registers on the clobber list may not be preserved across the asm statement, and clobbering them may lead to undefined behaviour.
+define void @test_r1_clobber() {
+entry:
+  call void asm sideeffect "nop", "~{r1}"()
+  ret void
+}