diff --git a/openmp/libomptarget/DeviceRTL/CMakeLists.txt b/openmp/libomptarget/DeviceRTL/CMakeLists.txt
--- a/openmp/libomptarget/DeviceRTL/CMakeLists.txt
+++ b/openmp/libomptarget/DeviceRTL/CMakeLists.txt
@@ -91,6 +91,13 @@
   endif()
 endforeach()
 
+
+set(amdgpu_mcpus gfx700 gfx701 gfx801 gfx803 gfx900 gfx902 gfx906 gfx908 gfx90a gfx1010 gfx1030 gfx1031)
+if (DEFINED LIBOMPTARGET_AMDGCN_GFXLIST)
+  set(amdgpu_mcpus ${LIBOMPTARGET_AMDGCN_GFXLIST})
+endif()
+
+
 # Activate RTL message dumps if requested by the user.
 set(LIBOMPTARGET_DEVICE_DEBUG FALSE CACHE BOOL
   "Activate DeviceRTL debug messages.")
@@ -121,11 +128,9 @@
 # Set flags for LLVM Bitcode compilation.
 set(bc_flags -S -x c++ -std=c++17
               ${clang_opt_flags}
-             -target nvptx64
              -Xclang -emit-llvm-bc
              -Xclang -aux-triple -Xclang ${aux_triple}
              -fopenmp -fopenmp-cuda-mode -Xclang -fopenmp-is-device
-             -Xclang -target-feature -Xclang +ptx61
              -I${include_directory}
              -I${devicertl_base_directory}/../include
              ${LIBOMPTARGET_LLVM_INCLUDE_DIRS_DEVICERTL}
@@ -137,23 +142,22 @@
   list(APPEND bc_flags -DOMPTARGET_DEBUG=0)
 endif()
 
-# Create target to build all Bitcode libraries.
-add_custom_target(omptarget-new-nvptx-bc)
-add_dependencies(omptarget-new-nvptx-bc opt llvm-link)
 
-# Generate a Bitcode library for all the compute capabilities the user requested
-foreach(sm ${nvptx_sm_list})
-  # TODO: replace this with declare variant and isa selector.
-  set(cuda_flags -Xclang -target-cpu -Xclang sm_${sm} "-D__CUDA_ARCH__=${sm}0")
+macro(instantiate_DeviceRTL)
+  # parameters target_cpu, target_name, target_bc_flags
+  
   set(bc_files "")
   foreach(src ${src_files})
     get_filename_component(infile ${src} ABSOLUTE)
     get_filename_component(outfile ${src} NAME)
-    set(outfile "${outfile}-sm_${sm}.bc")
+    set(outfile "${outfile}-${target_cpu}.bc")
 
     add_custom_command(OUTPUT ${outfile}
-      COMMAND ${CLANG_TOOL} ${bc_flags}
-        ${cuda_flags} ${infile} -o ${outfile}
+      COMMAND ${CLANG_TOOL}
+      ${bc_flags}
+      -Xclang -target-cpu -Xclang ${target_cpu}
+      ${target_bc_flags}
+      ${infile} -o ${outfile}
       DEPENDS ${infile}
       IMPLICIT_DEPENDS CXX ${infile}
       COMMENT "Building LLVM bitcode ${outfile}"
@@ -173,7 +177,7 @@
     list(APPEND bc_files ${outfile})
   endforeach()
 
-  set(bclib_name "libomptarget-new-nvptx-sm_${sm}.bc")
+  set(bclib_name "libomptarget-new-${target_name}-${target_cpu}.bc")
 
   # Add a file-level dependency to ensure that llvm-link and opt are up-to-date.
   # By default, add_custom_command only builds the tool if the executable is missing
@@ -205,17 +209,44 @@
 
   set_property(DIRECTORY APPEND PROPERTY ADDITIONAL_MAKE_CLEAN_FILES ${bclib_name})
 
-  set(bclib_target_name "omptarget-new-nvptx-sm_${sm}-bc")
+  set(bclib_target_name "omptarget-new-${target_name}-${target_cpu}-bc")
 
   add_custom_target(${bclib_target_name} ALL DEPENDS ${CMAKE_CURRENT_BINARY_DIR}/${bclib_name}_opt)
-  add_dependencies(omptarget-new-nvptx-bc ${bclib_target_name})
-  add_dependencies(${bclib_target_name} opt llvm-link)
 
   # Copy library to destination.
+  # Note: This is acting on the llvm-link'ed library, not the opt'ed one
   add_custom_command(TARGET ${bclib_target_name} POST_BUILD
                     COMMAND ${CMAKE_COMMAND} -E copy ${CMAKE_CURRENT_BINARY_DIR}/${bclib_name}
                     ${LIBOMPTARGET_LIBRARY_DIR})
 
   # Install bitcode library under the lib destination folder.
   install(FILES ${CMAKE_CURRENT_BINARY_DIR}/${bclib_name} DESTINATION "${OPENMP_INSTALL_LIBDIR}")
+endmacro()
+
+# Generate a Bitcode library for all the compute capabilities the user requested
+foreach(sm ${nvptx_sm_list})
+  set(target_cpu sm_${sm})
+  set(target_name nvptx)
+  
+  # TODO: replace CUDA_ARCH with declare variant and isa selector.
+  set(target_bc_flags
+    -target nvptx64
+    -Xclang -target-feature
+    -Xclang +ptx61
+    "-D__CUDA_ARCH__=${sm}0")
+
+  instantiate_DeviceRTL()
+endforeach()
+
+foreach(mcpu ${amdgpu_mcpus})
+  set(target_cpu ${mcpu})
+  set(target_name amdgpu)
+
+  set(target_bc_flags
+    -target amdgcn-amd-amdhsa
+    "-D__AMDGCN__"
+    -fvisibility=default
+    -nogpulib)
+
+    instantiate_DeviceRTL()
 endforeach()