diff --git a/llvm/include/llvm/Analysis/InlineAdvisor.h b/llvm/include/llvm/Analysis/InlineAdvisor.h
--- a/llvm/include/llvm/Analysis/InlineAdvisor.h
+++ b/llvm/include/llvm/Analysis/InlineAdvisor.h
@@ -222,7 +222,7 @@
     bool invalidate(Module &, const PreservedAnalyses &,
                     ModuleAnalysisManager::Invalidator &) {
       // InlineAdvisor must be preserved across analysis invalidations.
-      return false;
+      return !Advisor;
     }
     bool tryCreate(InlineParams Params, InliningAdvisorMode Mode,
                    StringRef ReplayFile);
diff --git a/llvm/lib/Transforms/IPO/Inliner.cpp b/llvm/lib/Transforms/IPO/Inliner.cpp
--- a/llvm/lib/Transforms/IPO/Inliner.cpp
+++ b/llvm/lib/Transforms/IPO/Inliner.cpp
@@ -1050,6 +1050,9 @@
 
   IAA.clear();
 
+  auto Inv = PreservedAnalyses::all();
+  Inv.abandon<InlineAdvisorAnalysis>();
+  MAM.invalidate(M, Inv);
   // The ModulePassManager has already taken care of invalidating analyses.
   return PreservedAnalyses::all();
 }
diff --git a/llvm/test/Transforms/Inline/pr52118.ll b/llvm/test/Transforms/Inline/pr52118.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/Inline/pr52118.ll
@@ -0,0 +1,9 @@
+; Test that the InlineAdvisor, upon being cleared, is re-created correctly.
+; RUN: opt -S -passes="default<O1>,cgscc(inline)" < %s | FileCheck %s
+
+define double @foo() local_unnamed_addr {
+entry:
+  ret double undef
+}
+
+; CHECK: @foo