diff --git a/llvm/lib/Passes/PassBuilderPipelines.cpp b/llvm/lib/Passes/PassBuilderPipelines.cpp
--- a/llvm/lib/Passes/PassBuilderPipelines.cpp
+++ b/llvm/lib/Passes/PassBuilderPipelines.cpp
@@ -722,8 +722,9 @@
 
   // Lastly, add the core function simplification pipeline nested inside the
   // CGSCC walk.
-  MainCGPipeline.addPass(createCGSCCToFunctionPassAdaptor(
-      buildFunctionSimplificationPipeline(Level, Phase)));
+  FunctionPassManager FPM = buildFunctionSimplificationPipeline(Level, Phase);
+  FPM.addPass(InvalidateAllAnalysesPass());
+  MainCGPipeline.addPass(createCGSCCToFunctionPassAdaptor(std::move(FPM)));
 
   MainCGPipeline.addPass(CoroSplitPass(Level != OptimizationLevel::O0));
 
@@ -792,6 +793,7 @@
   // FIXME: revisit how SampleProfileLoad/Inliner/ICP is structured.
   if (LoadSampleProfile)
     EarlyFPM.addPass(InstCombinePass());
+  EarlyFPM.addPass(InvalidateAllAnalysesPass());
   MPM.addPass(createModuleToFunctionPassAdaptor(std::move(EarlyFPM)));
 
   if (LoadSampleProfile) {
@@ -866,6 +868,7 @@
   invokePeepholeEPCallbacks(GlobalCleanupPM, Level);
 
   GlobalCleanupPM.addPass(SimplifyCFGPass());
+  GlobalCleanupPM.addPass(InvalidateAllAnalysesPass());
   MPM.addPass(createModuleToFunctionPassAdaptor(std::move(GlobalCleanupPM)));
 
   // Add all the requested passes for instrumentation PGO, if requested.
@@ -1148,6 +1151,8 @@
 
   OptimizePM.addPass(CoroCleanupPass());
 
+  OptimizePM.addPass(InvalidateAllAnalysesPass());
+
   // Add the core optimizing pipeline.
   MPM.addPass(createModuleToFunctionPassAdaptor(std::move(OptimizePM)));