diff --git a/clang/lib/CodeGen/TargetInfo.cpp b/clang/lib/CodeGen/TargetInfo.cpp
--- a/clang/lib/CodeGen/TargetInfo.cpp
+++ b/clang/lib/CodeGen/TargetInfo.cpp
@@ -3415,6 +3415,9 @@
 
   // If this is a struct, recurse into the field at the specified offset.
   if (llvm::StructType *STy = dyn_cast<llvm::StructType>(IRType)) {
+    if (!STy->getNumContainedTypes())
+      return nullptr;
+
     const llvm::StructLayout *SL = TD.getStructLayout(STy);
     unsigned Elt = SL->getElementContainingOffset(IROffset);
     IROffset -= SL->getElementOffset(Elt);
diff --git a/clang/test/CodeGen/X86/avx512fp16-abi.c b/clang/test/CodeGen/X86/avx512fp16-abi.c
--- a/clang/test/CodeGen/X86/avx512fp16-abi.c
+++ b/clang/test/CodeGen/X86/avx512fp16-abi.c
@@ -197,3 +197,44 @@
   // CHECK-CPP: define{{.*}} @_Z3fs26shalf2(double {{.*}}
   return s.a;
 };
+
+struct fsd {
+  float a;
+  struct {};
+  double b;
+};
+
+struct fsd pr52011() {
+  // CHECK: define{{.*}} { float, double } @
+}
+
+struct hsd {
+  _Float16 a;
+  struct {};
+  double b;
+};
+
+struct hsd pr52011_2() {
+  // CHECK: define{{.*}} { half, double } @
+}
+
+struct hsf {
+  _Float16 a;
+  struct {};
+  float b;
+};
+
+struct hsf pr52011_3() {
+  // CHECK: define{{.*}} <4 x half> @
+}
+
+struct fds {
+  float a;
+  double b;
+  struct {};
+};
+
+struct fds pr52011_4() {
+  // CHECK-C: define{{.*}} { float, double } @pr52011_4
+  // CHECK-CPP: define{{.*}} void @_Z9pr52011_4v({{.*}} sret
+}