diff --git a/llvm/lib/Analysis/Loads.cpp b/llvm/lib/Analysis/Loads.cpp
--- a/llvm/lib/Analysis/Loads.cpp
+++ b/llvm/lib/Analysis/Loads.cpp
@@ -451,8 +451,8 @@
                                               const Value *StorePtr,
                                               Type *StoreTy,
                                               const DataLayout &DL) {
-  APInt LoadOffset(DL.getTypeSizeInBits(LoadPtr->getType()), 0);
-  APInt StoreOffset(DL.getTypeSizeInBits(StorePtr->getType()), 0);
+  APInt LoadOffset(DL.getIndexTypeSizeInBits(LoadPtr->getType()), 0);
+  APInt StoreOffset(DL.getIndexTypeSizeInBits(StorePtr->getType()), 0);
   const Value *LoadBase = LoadPtr->stripAndAccumulateConstantOffsets(
       DL, LoadOffset, /* AllowNonInbounds */ false);
   const Value *StoreBase = StorePtr->stripAndAccumulateConstantOffsets(
diff --git a/llvm/unittests/Analysis/LoadsTest.cpp b/llvm/unittests/Analysis/LoadsTest.cpp
--- a/llvm/unittests/Analysis/LoadsTest.cpp
+++ b/llvm/unittests/Analysis/LoadsTest.cpp
@@ -28,6 +28,7 @@
   LLVMContext C;
   std::unique_ptr<Module> M = parseIR(C,
                                       R"IR(
+target datalayout = "p:64:64:64:32"
 %class = type <{ i32, i32 }>
 
 define i32 @f() {