diff --git a/utils/bazel/llvm-project-overlay/llvm/BUILD.bazel b/utils/bazel/llvm-project-overlay/llvm/BUILD.bazel
--- a/utils/bazel/llvm-project-overlay/llvm/BUILD.bazel
+++ b/utils/bazel/llvm-project-overlay/llvm/BUILD.bazel
@@ -2,6 +2,7 @@
 # See https://llvm.org/LICENSE.txt for license information.
 # SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
 
+load("@bazel_skylib//lib:selects.bzl", "selects")
 load(":template_rule.bzl", "template_rule")
 load(":tblgen.bzl", "gentbl")
 load(":config.bzl", "llvm_config_defines")
@@ -16,6 +17,39 @@
 
 exports_files(["LICENSE.TXT"])
 
+# Support for targeting macOS arm64 architecture with `bazel<4.2`. This
+# implementation is lifted from `src/conditions/BUILD` in the bazel source.
+config_setting(
+    name = "macos_x86_64",
+    constraint_values = [
+        "@platforms//os:macos",
+        "@platforms//cpu:x86_64",
+    ],
+    visibility = ["//visibility:public"],
+)
+
+config_setting(
+    name = "macos_arm64_constraint",
+    constraint_values = [
+        "@platforms//os:macos",
+        "@platforms//cpu:arm64",
+    ],
+)
+
+config_setting(
+    name = "macos_arm64_flag",
+    values = {"cpu": "darwin_arm64"},
+)
+
+selects.config_setting_group(
+    name = "macos_arm64",
+    match_any = [
+        ":macos_arm64_constraint",
+        ":macos_arm64_flag",
+    ],
+    visibility = ["//visibility:public"],
+)
+
 # It may be tempting to add compiler flags here, but that should be avoided.
 # The necessary warnings and other compile flags should be provided by the
 # toolchain or the `.bazelrc` file. This is just a workaround until we have a
diff --git a/utils/bazel/llvm-project-overlay/llvm/config.bzl b/utils/bazel/llvm-project-overlay/llvm/config.bzl
--- a/utils/bazel/llvm-project-overlay/llvm/config.bzl
+++ b/utils/bazel/llvm-project-overlay/llvm/config.bzl
@@ -75,7 +75,8 @@
 # TODO: We should split out host vs. target here.
 llvm_config_defines = os_defines + select({
     "@bazel_tools//src/conditions:windows": native_arch_defines("X86", "x86_64-pc-win32"),
-    "@bazel_tools//src/conditions:darwin": native_arch_defines("X86", "x86_64-unknown-darwin"),
+    "//llvm:macos_arm64": native_arch_defines("AArch64", "arm64-apple-darwin"),
+    "//llvm:macos_x86_64": native_arch_defines("X86", "x86_64-apple-darwin"),
     "@bazel_tools//src/conditions:linux_aarch64": native_arch_defines("AArch64", "aarch64-unknown-linux-gnu"),
     "//conditions:default": native_arch_defines("X86", "x86_64-unknown-linux-gnu"),
 }) + [