diff --git a/llvm/lib/CodeGen/StackColoring.cpp b/llvm/lib/CodeGen/StackColoring.cpp
--- a/llvm/lib/CodeGen/StackColoring.cpp
+++ b/llvm/lib/CodeGen/StackColoring.cpp
@@ -687,6 +687,8 @@
 
     // Walk the instructions in the block to look for start/end ops.
     for (MachineInstr &MI : *MBB) {
+      if (MI.isDebugInstr())
+        continue;
       if (MI.getOpcode() == TargetOpcode::LIFETIME_START ||
           MI.getOpcode() == TargetOpcode::LIFETIME_END) {
         int Slot = getStartOrEndSlot(MI);
diff --git a/llvm/test/CodeGen/X86/StackColoring-dbg-invariance.mir b/llvm/test/CodeGen/X86/StackColoring-dbg-invariance.mir
--- a/llvm/test/CodeGen/X86/StackColoring-dbg-invariance.mir
+++ b/llvm/test/CodeGen/X86/StackColoring-dbg-invariance.mir
@@ -74,9 +74,9 @@
 
     ; CHECK-LABEL: name: test_1
     ; CHECK: liveins: $edi
-    ; CHECK: DBG_VALUE %stack.1.a4, $noreg, !9, !DIExpression(), debug-location !11
+    ; CHECK: DBG_VALUE %stack.0.a1, $noreg, !9, !DIExpression(), debug-location !11
     ; CHECK: [[LEA64r:%[0-9]+]]:gr64 = LEA64r %stack.0.a1, 1, $noreg, 0, $noreg
-    ; CHECK: [[LEA64r1:%[0-9]+]]:gr64 = LEA64r %stack.1.a4, 1, $noreg, 0, $noreg
+    ; CHECK: [[LEA64r1:%[0-9]+]]:gr64 = LEA64r %stack.0.a1, 1, $noreg, 0, $noreg
     ; CHECK: RET 0
     DBG_VALUE %stack.3.a4, $noreg, !9, !DIExpression(), debug-location !11
     LIFETIME_START %stack.3.a4