diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -5084,9 +5084,9 @@
   }
 
   // Enable -mconstructor-aliases except on darwin, where we have to work around
-  // a linker bug (see <rdar://problem/7651567>), and CUDA/AMDGPU device code,
-  // where aliases aren't supported.
-  if (!RawTriple.isOSDarwin() && !RawTriple.isNVPTX() && !RawTriple.isAMDGPU())
+  // a linker bug (see <rdar://problem/7651567>), and CUDA device code, where
+  // aliases aren't supported.
+  if (!RawTriple.isOSDarwin() && !RawTriple.isNVPTX())
     CmdArgs.push_back("-mconstructor-aliases");
 
   // Darwin's kernel doesn't support guard variables; just die if we
diff --git a/clang/test/CodeGenCUDA/amdgpu-alias-undef-symbols.cu b/clang/test/CodeGenCUDA/amdgpu-alias-undef-symbols.cu
new file mode 100644
--- /dev/null
+++ b/clang/test/CodeGenCUDA/amdgpu-alias-undef-symbols.cu
@@ -0,0 +1,16 @@
+// RUN: %clang --offload-arch=gfx906 --cuda-device-only -x hip -emit-llvm -S -o - %s \
+// RUN:   -fgpu-rdc -O3 -mllvm -amdgpu-early-inline-all=true -mllvm -amdgpu-function-calls=false | \
+// RUN:   FileCheck %s
+
+#include "Inputs/cuda.h"
+
+// CHECK: %struct.B = type { i8 }
+struct B {
+
+  // CHECK: @_ZN1BC1Ei = hidden unnamed_addr alias void (%struct.B*, i32), void (%struct.B*, i32)* @_ZN1BC2Ei
+  __device__ B(int x);
+};
+
+__device__ B::B(int x) {
+
+}
diff --git a/llvm/lib/Target/AMDGPU/AMDGPUAlwaysInlinePass.cpp b/llvm/lib/Target/AMDGPU/AMDGPUAlwaysInlinePass.cpp
--- a/llvm/lib/Target/AMDGPU/AMDGPUAlwaysInlinePass.cpp
+++ b/llvm/lib/Target/AMDGPU/AMDGPUAlwaysInlinePass.cpp
@@ -93,6 +93,8 @@
 
   for (GlobalAlias &A : M.aliases()) {
     if (Function* F = dyn_cast<Function>(A.getAliasee())) {
+      if (!A.hasInternalLinkage())
+        continue;
       A.replaceAllUsesWith(F);
       AliasesToRemove.push_back(&A);
     }