diff --git a/llvm/lib/Transforms/IPO/GlobalOpt.cpp b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
--- a/llvm/lib/Transforms/IPO/GlobalOpt.cpp
+++ b/llvm/lib/Transforms/IPO/GlobalOpt.cpp
@@ -1615,8 +1615,10 @@
     // one other value was stored into it, we can just change the
     // initializer to be the stored value, then delete all stores to the
     // global.  This allows us to mark it constant.
+    // This is restricted to address space 0 globals. NVPTX, for example,
+    // does not support initializers for shared memory (AS 3).
     if (SOVConstant && SOVConstant->getType() == GV->getValueType() &&
-        isa<UndefValue>(GV->getInitializer())) {
+        isa<UndefValue>(GV->getInitializer()) && GV->getType()->getAddressSpace() == 0) {
       // Change the initial value here.
       GV->setInitializer(SOVConstant);
 
diff --git a/llvm/test/Transforms/GlobalOpt/address_space_initializer.ll b/llvm/test/Transforms/GlobalOpt/address_space_initializer.ll
new file mode 100644
--- /dev/null
+++ b/llvm/test/Transforms/GlobalOpt/address_space_initializer.ll
@@ -0,0 +1,29 @@
+; RUN: opt -passes=globalopt < %s -S | FileCheck %s
+
+; Check that we don't try to set a global initializer for non AS(0) globals.
+
+@g0 = internal global i16 undef
+@g1 = internal addrspace(3) global i16 undef
+; CHECK: internal unnamed_addr constant i16 3
+; CHECK: internal unnamed_addr addrspace(3) global i16 undef
+
+define void @a() {
+  store i16 3, i16* @g0, align 8
+  store i16 5, i16* addrspacecast (i16 addrspace(3)* @g1 to i16*), align 8
+  ret void
+}
+
+define i8 @get0() optnone noinline {
+  %bc = bitcast i16* @g0 to i8*
+  %gep = getelementptr i8, i8* %bc, i64 1
+  %r = load i8, i8* %gep
+  ret i8 %r
+}
+define i8 @get1() {
+  %ac = addrspacecast i16 addrspace(3)* @g1 to i16*
+  %bc = bitcast i16* %ac to i8*
+  %gep = getelementptr i8, i8* %bc, i64 1
+  %r = load i8, i8* %gep
+  ret i8 %r
+}
+