diff --git a/clang/lib/Driver/ToolChains/Clang.cpp b/clang/lib/Driver/ToolChains/Clang.cpp
--- a/clang/lib/Driver/ToolChains/Clang.cpp
+++ b/clang/lib/Driver/ToolChains/Clang.cpp
@@ -6192,7 +6192,8 @@
   // than 19.
   if (!Args.hasFlag(options::OPT_fthreadsafe_statics,
                     options::OPT_fno_threadsafe_statics,
-                    !IsWindowsMSVC || IsMSVC2015Compatible))
+                    !types::isOpenCL(InputType) &&
+                        (!IsWindowsMSVC || IsMSVC2015Compatible)))
     CmdArgs.push_back("-fno-threadsafe-statics");
 
   // -fno-delayed-template-parsing is default, except when targeting MSVC.
diff --git a/clang/test/Driver/threadsafe-statics.clcpp b/clang/test/Driver/threadsafe-statics.clcpp
new file mode 100644
--- /dev/null
+++ b/clang/test/Driver/threadsafe-statics.clcpp
@@ -0,0 +1,11 @@
+// RUN: %clang -### -c -DNO_THREADSAFE_STATICS %s 2>&1 | FileCheck --check-prefix=CHECK-NO-THREADSAFE-STATICS %s
+// RUN: %clang -### -fno-threadsafe-statics -DNO_THREADSAFE_STATICS -c %s 2>&1 | FileCheck --check-prefix=CHECK-NO-THREADSAFE-STATICS %s
+
+// CHECK-NO-THREADSAFE-STATICS: "-cc1"
+// CHECK-NO-THREADSAFE-STATICS: "-fno-threadsafe-statics"
+// CHECK-NO-THREADSAFE-STATICS-NOT: "-fthreadsafe-statics"
+
+// RUN: %clang -### -fthreadsafe-statics -DTHREADSAFE_STATICS -c %s 2>&1 | FileCheck --check-prefix=CHECK-THREADSAFE-STATICS %s
+
+// CHECK-THREADSAFE-STATICS: "-cc1"
+// CHECK-THREADSAFE-STATICS-NOT: "-fno-threadsafe-statics"